Thrombospondin-1 (1016-1023) (human, bovine, mouse)
Based on 1 Customer Validation
Thrombospondin-1 (1016-1023) (human, bovine, mouse), is the C-terminal end of the native sequence of Thrombospondin-1 (TSP-1), is a CD47 agonist peptide.
For research use only. We do not sell to patients.
- Purity : 98.75%
- CAS No.: 149234-04-8
- Formula: C56H81N13O10S
- Molecular Weight:1128.39
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
![[Pyr1]-Apelin-13](https://file.medchemexpress.com/product_pic/hy-p1033.gif)
Biological Activity
Description
In Vitro
Thrombospondin-1 (1016-1023) (human, bovine, mouse) (4N1K; 100 µg/mL; for 60 min) treatment has induced both phosphatidylserine exposure and loss of cell membrane integrity in monocyte-derived immature dendritic cells (DCs). With peptide concentrations of 25-200 µg/mL, the number of annexin V+ cells increased with peptide concentration. Thrombospondin-1 (1016-1023) (human, bovine, mouse) reduces mitochondrial membrane potential and fragmented DNA in DCs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 149234-04-8
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Appearance Solid
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Molecular Weight 1128.39
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Formula C56H81N13O10S
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Color White to off-white
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Sequence Shortening
RFYVVMWK
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
H2O : 14.29 mg/mL (12.66 mM; Need ultrasonic)
DMSO : ≥ 10 mg/mL (8.86 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Chih-Jian Lih, et al. Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes. Genes Dev. 2006 Aug 1;20(15):2082-95. [Content Brief]
[2]. U Johansson, et al. CD47 ligation induces a rapid caspase-independent apoptosis-like cell death in human monocytes and dendritic cells. Scand J Immunol. 2004 Jan;59(1):40-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 0.8862 mL | 4.4311 mL | 8.8622 mL | 22.1555 mL |
| 5 mM | 0.1772 mL | 0.8862 mL | 1.7724 mL | 4.4311 mL | |
| H2O | 10 mM | 0.0886 mL | 0.4431 mL | 0.8862 mL | 2.2155 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Thrombospondin-1 (1016-1023) (human, bovine, mouse) Related Classifications
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