2. Immunology/Inflammation
  3. Interleukin Related
  4. Ligufalimab

Ligufalimab  (Synonyms: AK 117)

Cat. No.: HY-P99706 Purity: 98.81%
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Ligufalimab (AK 117) is a humanized IgG4 anti-CD47 monoclonal antibody. Ligufalimab does not induce RBC hemagglutination, and induces phagocytosis. Ligufalimab shows anti-tumor activity.

For research use only. We do not sell to patients.

Ligufalimab Chemical Structure

Ligufalimab Chemical Structure

CAS No. : 2428381-55-7

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Ligufalimab Related Antibodies

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Description

Ligufalimab (AK 117) is a humanized IgG4 anti-CD47 monoclonal antibody. Ligufalimab does not induce RBC hemagglutination, and induces phagocytosis. Ligufalimab shows anti-tumor activity[1].

In Vitro

Ligufalimab binds to human CD47 antigen with an EC50 value of 0.078 nM, KD value of 0.152 nM[1].
Ligufalimab (0-3000 nM) does not induce RBC hemagglutination[1].
Ligufalimab (0.1, 1, 10 µg/mL) induces phagocytosis of Raji, Jurkat and Ramos cells in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ligufalimab Related Antibodies
In Vivo

Ligufalimab (0.1, 1 mg/kg for Raji xenograft, 0.2 mg/kg for MDA-MB-231 xenograft model) inhibits tumor growth in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID/Beige mice (Raji xenograft model, MDA-MB-231 xenograft model)[1]
Dosage: 0.1, 1 mg/kg for Raji xenograft, 0.2 mg/kg for MDA-MB-231 xenograft model
Administration: I.v.
Result: Inhibited tumor growth with the tumor inhibition rate of 88.56%, 63.78% at 1, 0.1 mg/kg.
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ligufalimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.81%

COA (231 KB)

Handling Instructions (2659 KB)
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Ligufalimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ligufalimab2428381-55-7AK 117AK117AK-117Interleukin RelatedILRBC hemagglutinationphagocytosisanti-tumorRajiMDA-MB-23Inhibitorinhibitorinhibit

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