Anti-Mouse Ter-119 Antibody (TER-119)
Based on 1 Customer Validation
Anti-Mouse Ter-119 Antibody (TER-119) is an anti-mouse Ter-119 IgG2b monoclonal antibody. Anti-Mouse Ter-119 Antibody (TER-119) can increase platelet count. Anti-Mouse Ter-119 Antibody (TER-119) can remove red blood cells and their precursor cells to isolate and enrich natural killer (NK) cells. Anti-Mouse Ter-119 Antibody (TER-119) can be used for research on immune thrombocytopenia. Anti-Mouse Ter-119 Antibody (TER-119) can be used to construct a model of immune thrombocytopenic purpura combined with CD41 mAb.
For research use only. We do not sell to patients.
- Purity : 98.58%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Rat IgG2b kappa
Recommend Isotype Controls
Species Reactivity
Mouse
In Vivo
Anti-Mouse Ter-119 Antibody (TER-119) (50 μg, i.p., single dose) can be used for the construction of immune thrombocytopenic purpura (ITP) model combined with CD41 mAb in female BALB/c mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD41 mAb induced female CD1 mice (6-8 weeks)[1]
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Dosage:25 μg
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Administration:Intraperitoneal injection (i.p.), single dose, on day 2
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Result:Significantly increased platelet count to 588-723×109/L on days 4-5.
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Animal Model:Female BALB/c mice[2]
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Dosage:50 μg, combined with CD41 mAb (1 μg)
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Administration:Intraperitoneal injection (i.p.), single dose
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Result:Reduced platelet count.
Significantly upregulated mRNA expression of CXCL-1 and CXCL-5 in the spleen.
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo administration; in vitro erythrocyte negative selection; Functional assays; Flow cytometr
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse Ter-119 Antibody (TER-119)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Katsman Y, et al. Improved mouse models for the study of treatment modalities for immune-mediated platelet destruction. Transfusion. 2010 Jun;50(6):1285-94. [Content Brief]
[2]. Aubin E, et al. Absence of cytokine modulation following therapeutic infusion of intravenous immunoglobulin or anti-red blood cell antibodies in a mouse model of immune thrombocytopenic purpura. Br J Haematol. 2007 Mar;136(6):837-43. [Content Brief]
[3]. Sheppard S, et al. Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function. Cell Rep. 2021 Jun 1;35(9):109210. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse Ter-119 Antibody (TER-119) Related Classifications
HY-P990158 Related Classifications
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