MAS825
Based on 1 Customer Validation
MAS825 (Arumakimig) is a bispecific monoclonal antibody targeting IL-1β and IL-18. MAS825 reduces inflammatory infiltration and pulmonary alveolar proteinosis, and improves blood oxygen saturation, exercise tolerance and quality of life. MAS825 also promotes viral clearance. MAS825 can be used in research related to systemic juvenile idiopathic arthritis complicated with interstitial lung disease or macrophage activation syndrome, as well as COVID-19.
For research use only. We do not sell to patients.
- Purity: 95.83%
- Molecular Weight:144.353 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Ig(G1-kappa_G1-lambda2)
Human
|
IL-1β |
IL-18 |
MAS825 binds to and neutralizes these two cytokines to effectively block pro-inflammatory pathways.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG1-lambda-kappa
ELISA, FACS, Functional assay
Chemical Information
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Appearance Liquid
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Molecular Weight 144.353 kDa
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Color Colorless to light yellow
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SMILES
N/A
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Synonyms
Arumakimig
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (258 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)