non-specific

By Targets:	5-HT Receptor (1) Amylases (1) Antibiotic (2) Apoptosis (2) Autophagy (6) Bacterial (3) Biochemical Assay Reagents (4) Calcium Channel (7) COX (1) Cytochrome P450 (1) DNA Methyltransferase (2) Dopamine Receptor (2) Drug Metabolite (2) Dynamin (1) Endogenous Metabolite (4) Fluorescent Dye (10) Histone Methyltransferase (2) HIV (4) IAP (1) iGluR (1) Liposome (1) mAChR (2) Mitophagy (1) Monoamine Oxidase (1) Neuropeptide Y Receptor (2) NOD-like Receptor (NLR) (3) Nucleoside Antimetabolite/Analog (1) Orthopoxvirus (1) P2Y Receptor (1) p62 (1) Parasite (1) Phosphatase (4) PKA (5) PKC (5) PPAR (1) ROCK (5) Ser/Thr Protease (1) Sodium Channel (2) Tryptophan Hydroxylase (1)
By Research Areas:	Cancer (25) Cardiovascular Disease (4) Endocrinology (1) Infection (5) Inflammation/Immunology (14) Metabolic Disease (6) Neurological Disease (14)

Targets Recommended: PSMA SNIPERs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126561

Green CMFDA CMFDA	Fluorescent Dye	Others
Green CMFDA is a cell-permeable fluorescent probe with Em of 514 nm and Ex of 485 nm and can be used as a cell tracer. Green CMFDA can be cleaved by non-specific esterases common in living cells, producing a fluorescent compound, fluorescein, visible using a fluorescent microscope .

HY-P2853

Hemocyanin	Endogenous Metabolite	Infection Inflammation/Immunology Cancer
Hemocyanin is a large copper-containing respiratory protein. Hemocyanin is an important non-specific innate immune defense molecule with phenoloxidase, antiviral, antibacterial, hemolytic, and antitumor activities .

HY-19695

(-)-p-Bromotetramisole oxalate 1 Publications Verification L-p-Bromotetramisole oxalate; 6-Bromolevamisole oxalate	Phosphatase	Cancer
(-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.

HY-B1056

Procodazole Propazol; 2-Benzimidazolepropionic acid	Bacterial	Infection
Procodazole is a non-specific active immunoprotective agent against viral and bacterial infections, used as a potentiator.

HY-148159

Safrazine	Monoamine Oxidase	Neurological Disease
Safrazine is an irreversible, non-specific and orally active monoamine oxidase (MAO) inhibitor. Safrazine can be used for the research of depression .

HY-113821

1-Naphthyl phosphate potassium salt	Phosphatase	Others
1-Naphthyl phosphate potassium salt is a non-specific phosphatase inhibitor. 1-Naphthyl phosphate potassium salt decreases the splice-correcting effect .

HY-E70208

EcoGII Methyltransferase EcoGII	DNA Methyltransferase	Others
EcoGII Methyltransferase (EcoGII) is a non-specific methyltransferase that modifies adenine residues (N6) in any sequence context .

HY-139852

PLAP-IN-1	Phosphatase	Cancer
PLAP-IN-1 is a potent (IC₅₀ = 32 nM) and selective PLAP inhibitor, with no detectable inhibition of tissue non-specific alkaline phosphatase (TNAP) activity.

HY-148796

Rizedisben GE3126	Fluorescent Dye	Others
Rizedisben (GE3126) is a fluorophore that can be used in fluorescence image-guided surgery. Rizedisben reduces non-specific adipose tissue fluorescence intensity and enhances nerve visibility .

HY-135530

Chinese gallotannin	Amylases	Metabolic Disease
Chinese gallotannin is a non-specific promiscuous α-amylase inhibitor with a K_i of 0.82 μg/mL for human salivary α-amylase. Chinese gallotannin can be used for the research of diabetes .

HY-155471

IMP 245	Others	Others
IMP 245 is a symmetric di-HSG bivalent hapten. IMP 245 has low toxicity, high affinity binding to available antibodies and absence of cross reactivity or non-specific binding with body components .

HY-101370

2-Methylthio-ATP tetrasodium	Others	Metabolic Disease
2-Methylthio-ATP tetrasodium is a non-specific P2-receptor agonist. 2-Methylthio-ATP tetrasodium causes noncompetitive inhibition of ADP-induced human platelet aggregation .

HY-108909

Chymopapain	Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Chymopapain is a non-specific proteo-glycanase derived from the papaya plant. Chymopapain directly into the intervertebral disc caused disc narrowing due to dissolution of the extruded material. Chymopapain has the potential for the research of herniated lumbar discs .

HY-12489

Ponceau S Acid Red 112	Fluorescent Dye	Others
Ponceau S (Acid Red 112) is a non-specific protein dye commonly used as a stain for Western blot. Ponceau S is used in an acidic aqueous solution that is compatible with antibody-antigen binding and dyes the proteins on the membrane red .

HY-135146

GSK-3484862 5+ Cited Publications	DNA Methyltransferase	Cancer
GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity .

HY-P0262A

Galantide TFA	Neuropeptide Y Receptor	Neurological Disease Metabolic Disease
Galantide TFA is a reversible and non-specific galanin (GAL) receptor antagonist. Galantide TFA dose-dependently shows antagonism to galanin-induced K ⁺ conductance with an IC₅₀ value of 4 nM. Galantide TFA can be used for the research of neurological disease and hormone metabolism research .

HY-121964

cis-Piperidine-2,3-dicarboxylic acid	iGluR	Neurological Disease
Cis-piperidine-2,3-dicarboxylic acid is a non-specific antagonist of NMDA, AMPA and kainate ionotropic receptors and a partial agonist for NMDA receptors. Cis-piperidine-2,3-dicarboxylic acid can be used in blocking general excitatory synaptic transmissions .

HY-124814

C215	Bacterial	Infection
C215 is a potent inhibitor of MmpL3. C215 is identified in HTS with glycerol independent activity against M. tuberculosis, limited non-specific toxicity against mammalian cells, an IC₉₀ of 16 μM against M. tuberculosis, and efficacy against M. tuberculosis growing in macrophages .

HY-D0047

5-CFDA 2 Publications Verification 5-Carboxyfluorescein diacetate	Fluorescent Dye	Others
5-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .

HY-D0721

6-CFDA 6-Carboxyfluorescein diacetate	Fluorescent Dye	Others
6-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .

HY-D0722

5(6)-CFDA 5 Publications Verification 5-(6)-Carboxyfluorescein diacetate; CFDA	Fluorescent Dye	Others
5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .

HY-N7648

Atherosperminine Atherospermine	Parasite	Infection
Atherosperminine（Atherospermine）is a nature occurring alkaloid, has antiplasmodial activities in vitro, with an IC₅₀ of 5.80 μM. Atherosperminine is a good reductant with the ability to chelate metals. Atherosperminine has scavenging activity towards the free radical DPPH, with an IC₅₀ of 29.56 µg/mL. Atherosperminine exerts a non-specific relaxant effect on the trachealis .

HY-126327

UNC4976	Histone Methyltransferase	Cancer
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA .

HY-D0846

Diethyl pyrocarbonate	Biochemical Assay Reagents	Neurological Disease
Diethyl pyrocarbonate is a potent, orally active, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues. Diethyl pyrocarbonate can be used for modeling .

HY-A0082

Diphenidol hydrochloride Difenidol hydrochloride	mAChR Sodium Channel	Neurological Disease
Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M₁-M₄ receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na ⁺, K ⁺, and Ca ²⁺) in neuronal cells. Diphenidol hydrochloride can be used in the study of antivertigo and antinausea .

HY-A0270

Diphenidol	mAChR Sodium Channel	Neurological Disease
Diphenidol is a non-selective muscarinic M₁-M₄ receptor antagonist, has anti-arrhythmic activity. Diphenidol is also a potent non-specific blocker of voltage-gated ion channels (Na ⁺, K ⁺, and Ca ²⁺) in neuronal cells. Diphenidol can be used in the study of antivertigo and antinausea .

HY-126327A

UNC4976 TFA	Histone Methyltransferase	Cancer
UNC4976 TFA is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 TFA simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA .

HY-115749

D-Luciferin 6′-methyl ether 6′-Methoxyluciferin	Others	Others
D-Luciferin 6′-methyl ether (6′-Methoxyluciferin; compound 19a) is a potent luciferase from the North American firefly Photinus pyralis (PpyLuc) inhibitor with an IC₅₀ of 0.1 µM. D-Luciferin 6′-methyl ether, a D-luciferin analog, shows non-specific interactions at ATP- and luciferin-binding sites of the PpyLuc active site .

HY-D1421

PKH 67 1 Publications Verification	Fluorescent Dye	Others
PKH67 is a fluorescent cell binding dye with green fluorescence. PKH67 can stain the cell membrane and the Ex/Em is 490/502 nm. PKH67 is often used in combination with the non-specific red fluorescent dye PKH26 (Ex/Em=551/567 nm) to label cells, detect cell proliferation in vitro, and trace cells in vitro and in vivo .

HY-135146A

(Rac)-GSK-3484862	Others	Cancer
(Rac)-GSK-3484862 is the isomer of GSK-3484862 (HY-135146), and can be used as an experimental control. GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity .

HY-13863

Hydroxy-Dynasore 3 Publications Verification Dyngo-4a	Dynamin	Neurological Disease
Hydroxy Dynasore (Dyngo-4a), a structural analog of Dynasore (HY-15304), is an potency improved, low cytotoxicity and non‐specific binding dynamin inhibitor with IC₅₀ values of 0.38 μM and 2.3 μM for brain dynamin I and recombinant rat dynamin II, respectively. Hydroxy Dynasore inhibits dynamin‐dependent endocytosis of transferrin with an IC₅₀ of 5.7 μM in vitro.

HY-P0262

Galantide	Neuropeptide Y Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology
Galantide, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide recognizes two classes of galanin binding sites (K_D<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide dose dependently (IC₅₀=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide appears to bind to a single population of SP receptors (K_D~40 nM) .

HY-115576

P62-mediated mitophagy inducer 3 Publications Verification PMI	p62 Mitophagy Autophagy	Neurological Disease Cancer
P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential .

HY-103389

1-Aminobenzotriazole 4 Publications Verification ABT; 3-Aminobenzotriazole	Cytochrome P450	Cancer
1-Aminobenzotriazole is a nonspecific and irreversible inhibitor of cytochrome P450 (P450).

HY-145127

ETZ C3-CA-DTZ	Fluorescent Dye	Neurological Disease
ETZ (C3-CA-DTZ) is a promising luciferase substrate (prosubstrate) activatable in vivo by nonspecific esterase to enhance the brain delivery of the luciferin .

HY-78144

4-Methylsalicylic acid	IAP	Inflammation/Immunology
4-Methylsalicylic acid is a salicylic acid. 4-Methylsalicylic acid derivative is a selective *tissue-nonspecific* alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP**) inhibitor .

HY-121966

Riparin Riparin III	Others	Cancer
Riparin is a nonspecific smooth muscle relaxant. Riparin inhibits CaCl2-induced contractions in a reversible and non-competitive manner and can be used in spasmolytic studies .

HY-131160

Nuclease, Serratia marcescens Serratia marcescens nuclease	Biochemical Assay Reagents	Inflammation/Immunology
Serratia marcescens nuclease (EC 3.1.30.2) is a nonspecific nuclease. Serratia marcescens nuclease has broad utility due to its potent digestive activity toward both DNA and RNA .

HY-N9680

Coenzyme Q8 Ubiquinone 8	Endogenous Metabolite	Metabolic Disease
Coenzyme Q8 (Ubiquinone 8) is an isoprenoid quinone that mediates electron transfer within the aerobic respiratory chain and mitigates oxidative stress. Coenzyme Q8 enhances nonspecific resistance to bacterial infections .

HY-144012

16:0 PEG2000 PE DPPE-PEG2000; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] ammonium	Liposome	Others
16:0 PEG2000 PE (DPPE-PEG2000) is a PEG-modified lipids. 16:0 PEG2000 PE can reduce the nonspecific adsorption of protein and prolong circulation time in vivo .

HY-W721582

β,β-Trehalose	Others	Others
β,β-Trehalose is a analog of trehalose. β,β-Trehalose can support the growth of shoot tips of Cuscuta. β,β-Trehalose can be cleaved by nonspecific β-glucosidase .

HY-W019599

4-Chloro-L-phenylalanine L-PCPA	5-HT Receptor Tryptophan Hydroxylase	Neurological Disease
4-Chloro-L-phenylalanine (L-PCPA) is a 5-HT biosynthesis inhibitor. 4-Chloro-L-phenylalanine is also a nonspecific antagonist of both isoforms of tryptophan hydroxylase (TPH1 and TPH2) .

HY-160046

AS2 sodium	Others	Cancer
AS2 sodium is an ssDNA aptamer (Kd: 0.7 nM) for prostate-specific antigen (PSA). AS2 sodium does not bind non-specifically to the anti-target and has the potential to be used in diagnostic systems for prostate cancer detection .

HY-116072

Antiarrhythmic agent-2	Calcium Channel	Cardiovascular Disease
Antiarrhythmic agent-2 is a nonspecific Ca ²⁺ inward current blocker that inhibits ionic currents in sensory neuron membranes. Antiarrhythmic agent-2 can be used in the study of cardiovascular diseases, such as arrhythmias .

HY-124756

SBI-425 1 Publications Verification	Phosphatase	Cardiovascular Disease
SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC₅₀=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival .

HY-B0078B

Dacarbazine hydrochloride Imidazole Carboxamide hydrochloride	Antibiotic	Cancer
Dacarbazine hydrochloride is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine hydrochloride inhibits T and B lymphoblastic response, with IC₅₀ values of 50 and 10 μg/mL, respectively. Dacarbazine hydrochloride can be used for the research of metastatic malignant melanoma .

HY-B0078

Dacarbazine 5+ Cited Publications Imidazole Carboxamide	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC₅₀ of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma .

HY-N3729

(-)-Denudatin B Denudatin B	Calcium Channel	Cardiovascular Disease
(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels . And (-)-Denudatin B has nonspecific antiplatelet action

HY-126437C

Poly-L-lysine hydrobromide (MW 150000-300000)	Others	Others
Poly-L-lysine hydrobromide (MW 150000-300000) is a lysine polymer. Poly-L-lysine hydrobromide is a nonspecific attachment factor for cells, promoting cell adhesion to solid substrates. Poly-L-lysine hydrobromide can be used as a coating substrate for culture dishes, slides, etc .

HY-13682

Mifamurtide 1 Publications Verification MTP-PE; L-MTP-PE; CGP 19835	NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
Mifamurtide (MTP-PE), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide is a specific ligand for NOD2 and acts as an insulin sensitizer. Mifamurtide has potential for use in rare disease and osteosarcoma research .

Cat. No.	Product Name

HY-L159

Highly Selective Activators Library

1468 compounds

Agonistic drugs activate or stimulate their receptors, triggering responses that increase or decrease cell activity. The highly selective activators can act on specific biological or molecular targets, while non-selective activators may interfere with multiple targets or targets simultaneously. The highly selective activators reduce the likelihood of these non-specific effects by targeting specific targets, making research more precise and reliable. The Highly Selective Activators Library contains 1468 compounds, covering multiple targets and subtypes, such as GPCR protein family, Ion channel, multiple kinases, etc. The Highly Selective Activators Library is an effective tool for screening different phenotypes.

HY-L166

Ion Channel Compound Library

1118 compounds

Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important.

MCE designs a unique collection of 1118 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

Cat. No.	Product Name	Type

HY-126561

Green CMFDA CMFDA	Fluorescent Dyes/Probes
Green CMFDA is a cell-permeable fluorescent probe with Em of 514 nm and Ex of 485 nm and can be used as a cell tracer. Green CMFDA can be cleaved by non-specific esterases common in living cells, producing a fluorescent compound, fluorescein, visible using a fluorescent microscope .

HY-12489

Ponceau S Acid Red 112	Dyes
Ponceau S (Acid Red 112) is a non-specific protein dye commonly used as a stain for Western blot. Ponceau S is used in an acidic aqueous solution that is compatible with antibody-antigen binding and dyes the proteins on the membrane red .

HY-D0047

5-CFDA 2 Publications Verification 5-Carboxyfluorescein diacetate	Fluorescent Dyes/Probes
5-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .

HY-D0721

6-CFDA 6-Carboxyfluorescein diacetate	Fluorescent Dyes/Probes
6-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .

HY-D0722

5(6)-CFDA 5 Publications Verification 5-(6)-Carboxyfluorescein diacetate; CFDA	Fluorescent Dyes/Probes
5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .

HY-115749A

(Rac)-Luciferin 6′-methyl ether sodium (Rac)-6′-Methoxyluciferin sodium	Fluorescent Dyes/Probes
D-Luciferin 6′-methyl ether (6′-Methoxyluciferin; compound 19a) sodium is a potent luciferase from the North American firefly Photinus pyralis (PpyLuc) inhibitor with an IC₅₀ of 0.1 μM. D-Luciferin 6′-methyl ether, a D-luciferin analog, shows non-specific interactions at ATP- and luciferin-binding sites of the PpyLuc active site .

HY-D1421

PKH 67 1 Publications Verification	Fluorescent Dyes/Probes
PKH67 is a fluorescent cell binding dye with green fluorescence. PKH67 can stain the cell membrane and the Ex/Em is 490/502 nm. PKH67 is often used in combination with the non-specific red fluorescent dye PKH26 (Ex/Em=551/567 nm) to label cells, detect cell proliferation in vitro, and trace cells in vitro and in vivo .

HY-123749

Tetramethylrhodamine-5-iodoacetamide 5-TMRIA	Dyes
Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) is a thiol-selective reactive dye that is used to non-specifically label proteins via the cysteine residues. Tetramethylrhodamine-5-iodoacetamide (5-TMRIA) can be used to covalently label DNA fragments .

Cat. No.	Product Name	Type

HY-P2853

Hemocyanin	Native Proteins
Hemocyanin is a large copper-containing respiratory protein. Hemocyanin is an important non-specific innate immune defense molecule with phenoloxidase, antiviral, antibacterial, hemolytic, and antitumor activities .

HY-19695

(-)-p-Bromotetramisole oxalate 1 Publications Verification L-p-Bromotetramisole oxalate; 6-Bromolevamisole oxalate	Biochemical Assay Reagents
(-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.

HY-156262

DEPC-Treated Water	Biochemical Assay Reagents
DEPC-Treated Water is ultrapure water that has been sterilized by high temperature and high pressure and does not contain nuclease. It can avoid contamination by non-specific endonucleases and exonucleases and does not affect RNase activity .

HY-D0846

Diethyl pyrocarbonate	Biochemical Assay Reagents
Diethyl pyrocarbonate is a potent, orally active, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues. Diethyl pyrocarbonate can be used for modeling .

HY-144012

16:0 PEG2000 PE DPPE-PEG2000; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] ammonium	Drug Delivery
16:0 PEG2000 PE (DPPE-PEG2000) is a PEG-modified lipids. 16:0 PEG2000 PE can reduce the nonspecific adsorption of protein and prolong circulation time in vivo .

HY-108717

Proteinase K 5 Publications Verification Protease K	Biochemical Assay Reagents
Proteinase K (Protease K) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K can be use for promoting methods of viral nucleic acid extraction, and detection .

HY-126437A

Poly-L-lysine hydrochloride

Drug Delivery

Poly-L-lysine hydrochloride is a nonspecific attachment factor for cells useful in promoting cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. Poly-L-lysine hydrochloride is a strong-attraction regulator that promotes liquid-liquid phase separation (LLPS) at low concentrations but suppresses LLPS at high concentrations. Antibacterial cationic peptide. .

Cat. No.	Product Name	Target	Research Area

HY-P2495A

OVA (241-270) (TFA)

Peptides Inflammation/Immunology

OVA (241-270) TFA, a non-specific cytotoxic T lymphocyte (CTL) peptide, is a fragmented peptide of OVA (ovalbumin) antigen .

HY-P0262A

Galantide TFA	Neuropeptide Y Receptor	Neurological Disease Metabolic Disease
Galantide TFA is a reversible and non-specific galanin (GAL) receptor antagonist. Galantide TFA dose-dependently shows antagonism to galanin-induced K ⁺ conductance with an IC₅₀ value of 4 nM. Galantide TFA can be used for the research of neurological disease and hormone metabolism research .

HY-126327A

UNC4976 TFA	Histone Methyltransferase	Cancer
UNC4976 TFA is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 TFA simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA .

HY-P2495

OVA (241-270)

Peptides Cancer

OVA (241-270), a non-specific cytotoxic T lymphocyte (CTL) peptide, is a fragmented peptide of OVA (ovalbumin) antigen .

HY-126327

UNC4976	Histone Methyltransferase	Cancer
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA .

HY-P0262

Galantide	Neuropeptide Y Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology
Galantide, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide recognizes two classes of galanin binding sites (K_D<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide dose dependently (IC₅₀=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide appears to bind to a single population of SP receptors (K_D~40 nM) .

HY-W019599

4-Chloro-L-phenylalanine L-PCPA	5-HT Receptor Tryptophan Hydroxylase	Neurological Disease
4-Chloro-L-phenylalanine (L-PCPA) is a 5-HT biosynthesis inhibitor. 4-Chloro-L-phenylalanine is also a nonspecific antagonist of both isoforms of tryptophan hydroxylase (TPH1 and TPH2) .

HY-126437B

Poly-L-lysine hydrobromide (MW 70000-150000)	Biochemical Assay Reagents	Others
Poly-L-lysine (hydrobromide) (MW 70000-150000), a positively charged amino acid polymer, is a nonspecific attachment factor for cells. Poly-L-lysine (hydrobromide) (MW 70000-150000) has good biocompatibility. Poly-L-lysine (hydrobromide) (MW 70000-150000) is used to increase cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface .

HY-126437D

Poly-L-lysine hydrobromide (MW ＞300000)	Biochemical Assay Reagents	Others
Poly-L-lysine hydrobromide (MW 150000-300000), a positively charged amino acid polymer, is a nonspecific attachment factor for cells. Poly-L-lysine hydrobromide (MW 150000-300000) has good biocompatibility. Poly-L-lysine hydrobromide (MW 150000-300000) is used to increase cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface .

Cat. No.	Product Name	Target	Research Area

HY-P9942

Sulesomab	Inhibitory Antibodies	Inflammation/Immunology
Sulesomab (IMMU-MN3) is a murine monoclonal antibody fragment of the IgG1 class that binds to Normal Cross-Reactive Antigen-90 present on leukocytes. Sulesomab is cleared into infection nonspecifically through increased capillary membrane permeability .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P2853

Hemocyanin	Structural Classification Natural Products Animals Source classification	Endogenous Metabolite
Hemocyanin is a large copper-containing respiratory protein. Hemocyanin is an important non-specific innate immune defense molecule with phenoloxidase, antiviral, antibacterial, hemolytic, and antitumor activities .

HY-135530

Chinese gallotannin	Structural Classification Source classification Sapindaceae Phenols Polyphenols Plants Harpullia pendula Planch. ex F.Muell.	Amylases
Chinese gallotannin is a non-specific promiscuous α-amylase inhibitor with a K_i of 0.82 μg/mL for human salivary α-amylase. Chinese gallotannin can be used for the research of diabetes .

HY-108909

Chymopapain	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Chymopapain is a non-specific proteo-glycanase derived from the papaya plant. Chymopapain directly into the intervertebral disc caused disc narrowing due to dissolution of the extruded material. Chymopapain has the potential for the research of herniated lumbar discs .

HY-N7648

Atherosperminine Atherospermine	Infection Alkaloids Classification of Application Fields Source classification Fissistigma glaucescens Plants Annonaceae Disease Research Fields	Parasite
Atherosperminine（Atherospermine）is a nature occurring alkaloid, has antiplasmodial activities in vitro, with an IC₅₀ of 5.80 μM. Atherosperminine is a good reductant with the ability to chelate metals. Atherosperminine has scavenging activity towards the free radical DPPH, with an IC₅₀ of 29.56 µg/mL. Atherosperminine exerts a non-specific relaxant effect on the trachealis .

HY-N9680

Coenzyme Q8 Ubiquinone 8	Structural Classification Natural Products Leguminosae Source classification Pisum sativum Linn Plants	Endogenous Metabolite
Coenzyme Q8 (Ubiquinone 8) is an isoprenoid quinone that mediates electron transfer within the aerobic respiratory chain and mitigates oxidative stress. Coenzyme Q8 enhances nonspecific resistance to bacterial infections .

HY-W721582

β,β-Trehalose	Structural Classification Polysaccharides Cuscuta reflexa Roxb. Source classification Plants Convolvulaceae Saccharides	Others
β,β-Trehalose is a analog of trehalose. β,β-Trehalose can support the growth of shoot tips of Cuscuta. β,β-Trehalose can be cleaved by nonspecific β-glucosidase .

HY-N3729

(-)-Denudatin B Denudatin B	Cardiovascular Disease Classification of Application Fields Piper betle L. Source classification Lignans Piperaceae Phenylpropanoids Plants Disease Research Fields	Calcium Channel
(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels . And (-)-Denudatin B has nonspecific antiplatelet action

HY-P2818

Alkaline phosphatase, Bovine intestine 1 Publications Verification Apase	Structural Classification Natural Products Animals Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	Endogenous Metabolite
Alkaline phosphatase, Bovine intestine (Apase) is a membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase can be used in molecular biology and enzyme-free analysis. Inhibition of tissue nonspecific alkaline phosphatase can block intracellular lipid accumulation .

Species:	Human (7) Mouse (1)
Tag:	His (8) SUMO (3) GST (1)
Source:	HEK293 (4) Sf9 insect cells (2) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P72131

	CEACAM6 Protein, Human (His-SUMO) Carcinoembryonic antigen related cell adhesion molecule 6 ; Carcinoembryonic antigen related cell adhesion molecule 6 non specific cross reacting antigen; ; Carcinoembryonic antigen-related cell adhesion molecule 6; CD 66c; CD66c; CD66c antigen; CEA LIKE PROTEIN; CEACAM 6; CEACAM6; CEAL; CEAM6_HUMAN; MGC93832; NCA; non specific cross reacting antigen; non-specific crossreacting antigen; Normal cross reacting antigen; Normal cross-reacting antigen	Human	E. coli
	The CEACAM6 protein is a cell surface glycoprotein that promotes calcium- and fibronectin-independent cell-cell adhesion and mediates homo- and heterosexual interactions with other carcinoembryonic antigen-related cell adhesion molecules. CEACAM6 Protein, Human (His-SUMO) is the recombinant human-derived CEACAM6 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of CEACAM6 Protein, Human (His-SUMO) is 286 a.a., with molecular weight of ~47.2 kDa.

HY-P701859

	SLK Protein, Pan paniscus (Sf9, GST) SLK; non-specific serine/threonine protein kinase	Others	Sf9 insect cells
	The SLK protein is a bifunctional mediator that affects apoptosis and actin stress fiber lysis, suggesting a role in programmed cell death and regulation of cytoskeletal dynamics. The specific molecular mechanisms coordinating these processes need to be further elucidated to facilitate research on the functional significance of SLK. SLK Protein, Pan paniscus (Sf9, GST) is the recombinant SLK protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of SLK Protein, Pan paniscus (Sf9, GST) is 1152 a.a., .

HY-P700471

	CEACAM6 Protein, Human (286a.a, HEK293, His) carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen); NCA; carcinoembryonic antigen-related cell adhesion molecule 6; CD66c; normal cross-reacting antigen; non-specific crossreacting antigen; CEAL	Human	HEK293
	The CEACAM6 protein is a cell surface glycoprotein that promotes calcium- and fibronectin-independent cell-cell adhesion and mediates homo- and heterosexual interactions with other carcinoembryonic antigen-related cell adhesion molecules. CEACAM6 Protein, Human (286a.a, HEK293, His) is the recombinant human-derived CEACAM6 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of CEACAM6 Protein, Human (286a.a, HEK293, His) is 286 a.a., with molecular weight of 32.6 kDa.

HY-P72133

	CEACAM8/CD66b Protein, Human (His-SUMO) Carcinoembryonic antigen CGM6; Carcinoembryonic antigen gene family member 6; Carcinoembryonic antigen related cell adhesion molecule 8; Carcinoembryonic antigen-related cell adhesion molecule 8; CD 66b; CD 67; CD66b; CD66b antigen; CD67; CD67 antigen; CEACAM 8; CEACAM8; CEAM8_HUMAN; CGM 6; CGM6; NCA 95; NCA95; non-specific cross-reacting antigen NCA-95; nonspecific cross reacting antigen NCA 95; nonspecific cross reacting antigen NCA95	Human	E. coli
	CEACAM8/CD66b protein is a cell surface glycoprotein that promotes calcium-independent heterophil cell adhesion to other carcinoembryonic antigen-related cell adhesion molecules, particularly CEACAM6, in activated neutrophils Especially obvious. CEACAM8/CD66b Protein, Human (His-SUMO) is the recombinant human-derived CEACAM8/CD66b protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of CEACAM8/CD66b Protein, Human (His-SUMO) is 286 a.a., with molecular weight of ~47.5 kDa.

HY-P72130

	CEACAM3 Protein, Human (His-SUMO) carcinoembryonic ; Carcinoembryonic antigen CGM1; Carcinoembryonic antigen gene family member 1; carcinoembryonic antigen related cell adhesion molecule 3; Carcinoembryonic antigen-related cell adhesion molecule 3; cd66 d; CD66d; CD66d antigen; CEA; CEACAM 3; CEACAM-3; Ceacam3; CEAM 3; CEAM-3; CEAM3; CEAM3_HUMAN; CGM1; nonspecific cross reacting antigen; W264; W282	Human	E. coli
	The CEACAM3 protein is a key granulocyte receptor that effectively orchestrates the opsonin-independent phagocytosis of CEACAM-bound microorganisms such as Neisseria spp., Moraxella spp., and Haemophilus spp. This role places CEACAM3 at the forefront of pathogen clearance in the innate immune system. CEACAM3 Protein, Human (His-SUMO) is the recombinant human-derived CEACAM3 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of CEACAM3 Protein, Human (His-SUMO) is 121 a.a., with molecular weight of ~29.1 kDa.

HY-P70103

	CNDP2 Protein, Mouse (HEK293, His) rMuCytosolic non-specific dipeptidase/CNDP2, His; CNDP2; CNDP dipeptidase 2; Cytosolic non-specific dipeptidase; Glutamate carboxypeptidase-like protein 1; Cn2	Mouse	HEK293
	CNDP2 Protein, an enzyme, plays a vital role in the metabolism of carnosine and homocarnosine. Dysregulation of CNDP2 Protein has been linked to diabetic nephropathy and neurodegenerative disorders. Targeting CNDP2 Protein may offer potential therapeutic strategies by regulating carnosine metabolism, improving renal function, and potentially treating these conditions. CNDP2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CNDP2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CNDP2 Protein, Mouse (HEK293, His) is 475 a.a., with molecular weight of 56-60 kDa.

HY-P76837

	CNDP2 Protein, Human (sf9, His) Cytosolic non-specific dipeptidase; CNDP dipeptidase 2; Peptidase A; CN2; CPGL; HEL-S-13; PEPA	Human	Sf9 insect cells
	The CNDP2 protein is a catalyst that coordinates the oxidative cleavage of heme at the α-methylene bridge carbon, releasing carbon monoxide (CO) and generating biliverdin IXalpha. This enzymatic process releases ferrous iron from the central heme iron chelate. CNDP2 Protein, Human (sf9, His) is the recombinant human-derived CNDP2 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of CNDP2 Protein, Human (sf9, His) is 475 a.a., with molecular weight of ~54.2 kDa.

HY-P71238

	PS-beta-G-5 Protein, Human (HEK293, His) Pregnancy-specific beta-1-glycoprotein 5; PS-beta-G-5; PSBG-5; Pregnancy-specific glycoprotein 5; Fetal liver non-specific cross-reactive antigen 3; FL-NCA-3	Human	HEK293
	PS-beta-G-5 Protein, a major secreted protein group synthesized by placental syncytiotrophoblast cells, promotes the selective activation of macrophages and is associated with the transition from inflammatory Th1-mediated immune response to anti-inflammatory Th2-mediated immune response in vitro and in vivo. PS-beta-G-5 Protein, Human (HEK293, His) is the recombinant human-derived PS-beta-G-5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PS-beta-G-5 Protein, Human (HEK293, His) is 301 a.a., with molecular weight of ~50.0 kDa.

HY-P7880

	Alkaline Phosphatase/ALPL Protein, Human (HEK293, His) rHuAlkaline phosphatase, tissue-nonspecific isozyme/ALPL, His; Alkaline Phosphatase; Tissue-nonspecific Isozyme; AP-TNAP; TNSALP; Alkaline Phosphatase Liver/Bone/Kidney Isozyme; ALPL	Human	HEK293
	Alkaline Phosphatase/ALPL Protein, Human (HEK 293, His) is a cell-surface homodimeric phosphohydrolase that is richly expressed in the skeleton, liver, kidney and developing teeth.

Cat. No.	Product Name	Application	Reactivity

HY-P83606

CEACAM6 Antibody (YA3351)

CD66c; CEACAM6; CEAL; NCA; non specific cross reacting antigen; Normal cross reacting antigen
WB, IHC-P, ICC/IF, IP Human, Mouse, Rat


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