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CNDP2 Protein, Human (sf9, His)

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The CNDP2 protein is a catalyst that coordinates the oxidative cleavage of heme at the α-methylene bridge carbon, releasing carbon monoxide (CO) and generating biliverdin IXalpha. This enzymatic process releases ferrous iron from the central heme iron chelate. CNDP2 Protein, Human (sf9, His) is the recombinant human-derived CNDP2 protein, expressed by Sf9 insect cells , with C-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: Sf9 insect cells
  • Storage:
    Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
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Biological Activity

Description

The CNDP2 protein is a catalyst that coordinates the oxidative cleavage of heme at the α-methylene bridge carbon, releasing carbon monoxide (CO) and generating biliverdin IXalpha. This enzymatic process releases ferrous iron from the central heme iron chelate. CNDP2 Protein, Human (sf9, His) is the recombinant human-derived CNDP2 protein, expressed by Sf9 insect cells , with C-His labeled tag.

Background

HO-2/HMOX2 protein serves as a catalyst in the oxidative cleavage of heme at the alpha-methene bridge carbon, liberating carbon monoxide (CO) and producing biliverdin IXalpha. This enzymatic process results in the release of the central heme iron chelate as ferrous iron. HO-2/HMOX2 plays a crucial role in the breakdown of heme, facilitating the controlled generation of signaling molecules such as CO and biliverdin. The release of CO, in particular, has various physiological implications, contributing to vascular homeostasis, anti-inflammatory responses, and cellular protection. This enzyme's activity is integral to the regulation of heme metabolism and the maintenance of cellular redox balance.

Verified Bioactivity

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Technical Parameters

  • Species Human
  • Source Sf9 insect cells
  • Tag C-His
  • Accession

    Q96KP4-1 (M1-D475)

  • Gene ID
    55748  [NCBI]
  • Molecular Construction
    • N-term
    • CNDP2 (M1-D475)
      Accession # Q96KP4-1
    • His
    • C-term
  • Protein Length

    Full Length of Isoform-1

  • Synonyms

    CNDP2; Glutamate Carboxypeptidase-Like Protein 1; Prev. PEPA; Carnosine Dipeptidase II; CPGL; CNDP Dipeptidase 2; CN2; Carnosinase-2; Cytosolic Non-Specific Dipeptidase; FLJ10830; Threonyl Dipeptidase; HEL-S-13; Peptidase A; Epididymis Secretory Protein L

  • AA Sequence

    MAALTTLFKYIDENQDRYIKKLAKWVAIQSVSAWPEKRGEIRRMMEVAAADVKQLGGSVELVDIGKQKLPDGSEIPLPPILLGRLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVERDGKLYGRGSTDDKGPVAGWINALEAYQKTGQEIPVNVRFCLEGMEESGSEGLDELIFARKDTFFKDVDYVCISDNYWLGKKKPCITYGLRGICYFFIEVECSNKDLHSGVYGGSVHEAMTDLILLMGSLVDKRGNILIPGINEAVAAVTEEEHKLYDDIDFDIEEFAKDVGAQILLHSHKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPNMTPEVVGEQVTSYLTKKFAELRSPNEFKVYMGHGGKPWVSDFSHPHYLAGRRAMKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRYNYIEGTKMLAAYLYEVSQLKD

  • Predicted Molecular Mass

    54.2 kDa

  • Molecular Weight

    Approximately 54 kDa, based on SDS-PAGE under reducing conditions.

  • Purity

    ≥ 90%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Solution

Formulation

Supplied as a 0.22 μm filtered solution of 50 mM Tris, 100 mM NaCl, 0.5 mM PMSF, pH 8.0.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Storage & Stability

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Calculators

Reconstitution Calculator

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
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Biological Activity (ED50) Biological Activity (ED50)
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MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

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