CNDP2 - carnosine dipeptidase 2 Gene

Also Known as CN2; CPGL; PEPA; HsT2298; HEL-S-13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55748

About CNDP2

Cytogenetic location: 18q22.3 Genomic coordinates (GRCh38): 18:74,496,363-74,523,454 (from NCBI)

This gene has 29 transcripts (splice variants), 223 orthologues and 3 paralogues. Ubiquitous expression in kidney (RPKM 58.4), small intestine (RPKM 41.5) and 24 other tissues.

Summary

CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]

CNDP2 Products (6)

mRNA Protein Name
NM_001168499.2 NP_001161971.1 cytosolic non-specific dipeptidase isoform 2
NM_001370248.1 NP_001357177.1 cytosolic non-specific dipeptidase isoform 1
NM_001370249.1 NP_001357178.1 cytosolic non-specific dipeptidase isoform 1
NM_001370250.1 NP_001357179.1 cytosolic non-specific dipeptidase isoform 1
NM_001370254.1 NP_001357183.1 cytosolic non-specific dipeptidase isoform 3
NM_018235.3 NP_060705.2 cytosolic non-specific dipeptidase isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
33961781 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNDP2 Protein Structure

Peptidase_M20

Peptidase_M20: Peptidase family M20/M25/M40 (95 - 468)

M20_dimer

M20_dimer: Peptidase dimerisation domain (208 - 366)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 475 a.a.
Protein Preferred Names Protein Names

cytosolic non-specific dipeptidase

  • CNDP dipeptidase 2 (metallopeptidase M20 family)

Recombinant CNDP2 Proteins

Cat. No. Product Name Accession Purity
HY-P76837 CNDP2 Protein, Human (sf9, His) Q96KP4-1 (M1-D475) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Penile Cancer

  • Penis Carcinoma

  • Carcinoma Of Penis

  • Penile Neoplasm

  • Penile Carcinoma

  • Penile Neoplasms

  • Malignant Neoplasm Of Penis

  • Ca Penis

  • Malignant Neoplasm Of Body Of Penis

  • Malignant Penile Tumor

  • Penile Ca
Intermediate Malignant Teratoma

  • Malignant Teratoma, Intermediate

  • Intermediate Immature Teratoma
Pyriform Sinus Cancer

  • Malignant Neoplasm Of Pyriform Fossa

  • Malignant Neoplasm Of The Pyriform Fossa

  • Malignant Tumor Of Pyriform Fossa
Supraglottis Neoplasm

  • Neoplasm Of Supraglottis

  • Supraglottic Tumor
Penile Disease

  • Penile Diseases
Trachea Carcinoma

  • Pancoast Tumor

  • Carcinoma Of The Trachea

  • Pancoast'S Tumor

  • Malignant Superior Sulcus Tumor

  • Malignant Superior Sulcus Tumour

  • Pancoast Tumour

  • Pancoast'S Syndrome

  • Pancoast'S Tumour

  • Pulmonary Sulcus Tumor

  • Pulmonary Sulcus Tumour

  • Superior Pulmonary Sulcus Syndrome

  • Pancoast Syndrome
Penile Benign Neoplasm

  • Neoplasm Of Penis

  • Penile Tumor

  • Cancer Of Penis

  • Carcinoma Of Penis

  • Malignant Neoplasm Of Penis, Unspecified

  • Malignant Neoplasm Of Penis, Part Unspecified

  • Malignant Tumour Of Penis

  • Penile Cancer

  • Primary Malignant Neoplasm Of Penis

  • Malignant Neoplasm Of Skin Of Penis Nos
Crigler-Najjar Syndrome, Type I

  • Crigler-Najjar Syndrome

  • Crigler-Najjar Syndrome Type 1

  • Bilirubin Udp Glucuronyl Transferase Deficiency

  • Crigler Najjar Syndrome

  • Crigler Najjar Syndrome, Type 1

  • Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency

  • Bilirubin-Ugt Deficiency

  • Hyperbilirubinemia, Crigler-Najjar Type I

  • Hblrcn1

  • Familial Nonhemolytic Unconjugated Hyperbilirubinemia

  • Hereditary Unconjugated Hyperbilirubinemia

  • Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1

  • Bilirubin-Ugt Deficiency Type 1

  • Crigler-Najjar Syndrome 1

  • CN1

  • Cn-I

  • Crigler-Najjar Syndrome Type I

  • Hereditary Unconjugated Hyperbilirubinaemia

  • Ugt Deficiency

  • Bilirubin Glucuronosyltransferase Deficiency

  • Crigler-Najjar Disease Or Syndrome

  • Deficiency Of Glucuronosyltransferase

  • Glucuronyl Transferase Deficiency

  • Glucuronyltransferase Deficiency

  • Udp Glucuronyl Transferase Deficiency

  • Cns - [Crigler-Najjar Syndrome]

  • Congenital Familial Nonhemolytic Jaundice
Tolosa-Hunt Syndrome

  • Painful Ophthalmoplegia

  • Tolosa Hunt Syndrome

  • Nonspecific Inflammation Of The Cavernous Sinus Or Superior Orbital Fissure

  • Ths

  • Ophthalmoplegia, Painful
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Gilbert Syndrome

  • Gilbert Disease

  • Gilbert'S Disease

  • Gilbert'S Syndrome

  • Cholemia, Familial

  • Familial Nonhemolytic Jaundice

  • Meulengracht Syndrome

  • Gilbert Syndrome, Susceptibility To

  • Hyperbilirubinemia, Gilbert Type

  • Hblrg

  • Hyperbilirubinemia, Arias Type

  • Hyperbilirubinemia I

  • Constitutional Hyperbilirubinemia

  • Gilbert-Meulengracht Syndrome

  • Hereditary Nonhemolytic Jaundice

  • Hyperbilirubinemia Arias Type

  • Hyperbilirubinemia Type 1

  • Constitutional Liver Dysfunction

  • Gilbert-Lereboullet Syndrome

  • Hyperbilirubinemia 1

  • Unconjugated Benign Bilirubinemia

  • GILBS

  • Gilberts Syndrome

  • Familial Nonhaemolytic Jaundice

  • Constitutional Hyperbilirubinaemia

  • Hereditary Nonhaemolytic Bilirubinaemia

  • Familial Nonhaemolytic Bilirubinaemia

  • Idiopathic Hyperbilirubinaemia

  • Icterus Intermittens Juvenilis

  • Chronic Intermittent Juvenile Jaundice

  • Low-Grade Chronic Hyperbilirubinaemia Syndrome

  • Benign Unconjugated Bilirubinaemia Syndrome

  • Hereditary Nonhaemolytic Jaundice

  • Idiopathic Unconjugated Hyperbilirubinaemia

  • Gilbert--Lereboullet Syndrome

  • Constitutional Hepatic Dysfunction

  • Meulengracht Icterus

  • Cholaemia Familiaris Simplex

  • Familial Cholaemia

  • Congenital Familial Cholaemia

  • Physiologic Cholaemia

  • Hyperbilirubinaemia Type 1

  • Gilbert Cholaemia
Bilirubin Metabolic Disorder

  • Hyperbilirubinemia

  • Hereditary Hyperbilirubinemia

  • Hyperbilirubinemia, Hereditary

  • Hyperbilirubinaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02877 CNDP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18385 Cndp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24866 Cndp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CNDP2 VGNC VGNC:61009
Mus musculus CNDP2 MGD MGI:1913304
Canis familiaris CNDP2 VGNC VGNC:39392
Macaca mulatta CNDP2 VGNC VGNC:71337
Bos taurus CNDP2 VGNC VGNC:27494
Rattus norvegicus CNDP2 RGD RGD:1305827
Others CNDP2 NCBI