2. Anti-infection
  3. Bacterial
  4. C215

C215 is a potent inhibitor of MmpL3. C215 is identified in HTS with glycerol independent activity against M. tuberculosis, limited non-specific toxicity against mammalian cells, an IC90 of 16 μM against M. tuberculosis, and efficacy against M. tuberculosis growing in macrophages.

For research use only. We do not sell to patients.

C215 Chemical Structure

C215 Chemical Structure

CAS No. : 912780-51-9

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10 mg USD 295 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

C215 is a potent inhibitor of MmpL3. C215 is identified in HTS with glycerol independent activity against M. tuberculosis, limited non-specific toxicity against mammalian cells, an IC90 of 16 μM against M. tuberculosis, and efficacy against M. tuberculosis growing in macrophages[1].

Molecular Weight

334.24

Formula

C17H17Cl2N3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCN1C2=CC=C(NCC3=CC=C(Cl)C=C3Cl)C=C2N=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (186.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9919 mL 14.9593 mL 29.9186 mL
5 mM 0.5984 mL 2.9919 mL 5.9837 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9919 mL 14.9593 mL 29.9186 mL 74.7966 mL
5 mM 0.5984 mL 2.9919 mL 5.9837 mL 14.9593 mL
10 mM 0.2992 mL 1.4959 mL 2.9919 mL 7.4797 mL
15 mM 0.1995 mL 0.9973 mL 1.9946 mL 4.9864 mL
20 mM 0.1496 mL 0.7480 mL 1.4959 mL 3.7398 mL
25 mM 0.1197 mL 0.5984 mL 1.1967 mL 2.9919 mL
30 mM 0.0997 mL 0.4986 mL 0.9973 mL 2.4932 mL
40 mM 0.0748 mL 0.3740 mL 0.7480 mL 1.8699 mL
50 mM 0.0598 mL 0.2992 mL 0.5984 mL 1.4959 mL
60 mM 0.0499 mL 0.2493 mL 0.4986 mL 1.2466 mL
80 mM 0.0374 mL 0.1870 mL 0.3740 mL 0.9350 mL
100 mM 0.0299 mL 0.1496 mL 0.2992 mL 0.7480 mL
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C215 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C215912780-51-9C 215C-215BacterialMmpL3glycerolM. tuberculosistoxicitymacrophagesInhibitorinhibitorinhibit

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