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  4. Dacarbazine citrate

Dacarbazine citrate  (Synonyms: Imidazole Carboxamide citrate)

Cat. No.: HY-B0078A
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Dacarbazine citrate is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine citrate inhibits T and B lymphoblastic response, with IC50 values of 50 and 10 μg/mL, respectively. Dacarbazine Citrate can be used for the research of apoptosis and various cancers such as metastatic malignant melanoma.

For research use only. We do not sell to patients.

CAS No. : 64038-56-8

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Dacarbazine citrate Related Antibodies

Top Publications Citing Use of Products

    Dacarbazine citrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Apr 9;16(1):268.  [Abstract]

    Dacarbazine (20 mg/kg; i.p.; 20 d) reduced tumor growth rates and tumor sizes of melanoma xenograft mice.

    Dacarbazine citrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Dec;11(48):e2408707.  [Abstract]

    Dacarbazine (DTIC) (500 µM; 72 h) reduced the diameter and metabolic activity of MCTs except monoculture tumoroids, especially the triples and quadruples, resulting in a decrease of approximately 32% and 28% in relative diameter, respectively, and caused a high number of apoptotic cells to detach from the main structure.

    Dacarbazine citrate purchased from MedChemExpress. Usage Cited in: Nature. 2023 Jun;618(7964):374-382.  [Abstract]

    Dacarbazine (60 mg/kg; i.p.; every other day for 8 d) significantly reduced red blood cell (RBC), reticulocyte (RET), and hemoglobin (HGB) counts in PBS- or B16F10-CL-EVP-educated mice.

    Dacarbazine citrate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2023 Oct 19;21(1):383.  [Abstract]

    Dacarbazine (DAC) (5 mg/kg; i.v.; once every three days for 3 times) caused significant cell necrosis and nucleopaenia in tumors of B16F10 tumor-bearing mice.

    Dacarbazine citrate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2023 Oct 19;21(1):383.  [Abstract]

    Dacarbazine (DAC) (5 mg/kg; i.v.; once every three days for 3 times) significantly inhibited the growth of subcutaneous B16F10 melanoma xenografts in C57BL/6 mice.

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    Description

    Dacarbazine citrate is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine citrate inhibits T and B lymphoblastic response, with IC50 values of 50 and 10 μg/mL, respectively. Dacarbazine Citrate can be used for the research of apoptosis and various cancers such as metastatic malignant melanoma[1][2].

    In Vitro

    Dacarbazine citrate has less pronounced inhibition of mitogenesis with IC50 values of 50 and 10 μg/mL for T and B cells, respectively[2].
    Dacarbazine citrate (30 μM, 0-14 min) evokes a concentration-dependent calcium response in hTRPA1-HEK293 cells with an EC50 value of 23 μM and selectively activates the human TRPA1 channel[3].
    Dacarbazine citrate (100-10,000 μM, 24 h) has cytotoxic action on B16-F10 melanoma cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Dacarbazine citrate Related Antibodies

    Cell Viability Assay[3]

    Cell Line: B16-F10 cell
    Concentration: 100-10,000 μM
    Incubation Time: 24 h
    Result: Reduced cell viability to 3,000 and 10,000 uM, with an inhibition percentage of 62 ± 2% after 24 h of incubation.
    In Vivo

    Dacarbazine citrate (1 mg/kg, i.p.) evokes a concentration-dependent calcium response and the maximum calcium response with an EC50 value of 16 μM in a subset of cells of cultured mouse DRG neurons and excites TRPA1 in rodent sensory neurons[3].
    Dacarbazine citrate (1 mg/kg, i.p.; 1, 3, 5 and 7 days for chronic pain or 1 mg/kg, i.p. for acute treatment) induces mechanical and cold allodynia in mice[3].
    Dacarbazine citrate-induced nociception can be reduced by TRPA1-deficient mice and antisense oligonucleotide for the TRPA1 receptor[3].
    Dacarbazine citrate-induced chronic nociception can be reduced by selective TRPA1 receptor antagonists and antioxidants[3].
    Dacarbazine citrate-induced nociception can be resisted by RPA1 antagonist or an antioxidant in a tumor-associated cancer pain model[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57BL/6, Trpa1+/+ or Trpa1−/− mice[3]
    Dosage: 1 mg/kg
    Administration: 1 mg/kg, i.p. (for acute treatment); 1 mg/kg, i.p.; 1, 3, 5 and 7 days (for chronic pain)
    Result: Caused mechanical allodynia with acute or repeated administration.
    Clinical Trial
    Molecular Weight

    374.31

    Formula

    C12H18N6O8
    CAS No.
    SMILES

    O=C(C1=C(/N=N/N(C)C)NC=N1)N.O=C(CC(C(O)=O)(O)CC(O)=O)O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Dacarbazine citrate Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Dacarbazine64038-56-8Imidazole CarboxamideApoptosisAntibioticcell cycleantineoplasticalkylating agentT lymphoblasticB lymphoblasticmetastatic malignant melanomacancerInhibitorinhibitorinhibit

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