1. Cell Cycle/DNA Damage
  2. Nucleoside Antimetabolite/Analog
  3. Dacarbazine

Dacarbazine (Synonyms: Imidazole Carboxamide)

Cat. No.: HY-B0078 Purity: >98.0%
Handling Instructions

Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent.

For research use only. We do not sell to patients.

Dacarbazine Chemical Structure

Dacarbazine Chemical Structure

CAS No. : 4342-03-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
200 mg USD 72 In-stock
Estimated Time of Arrival: December 31
1 g USD 120 In-stock
Estimated Time of Arrival: December 31
5 g   Get quote  
10 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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  • Technical Information

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Description

Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent. It has significant activity against melanomas. Target: Nucleoside antimetabolite/analog Approved: May 1975 Dacarbazine (DTIC) is the only single-agent approved by the Food and Drug Administration for treating metastatic melanoma. With DTIC as single agent, an approximately 20% objective response rate can be achieved with median response duration of 5 to 6 months and complete response rates of 5% [1]. Dacarbazine (DTIC) has activity in advanced previously untreated pancreatic islet cell tumors [2]. In the intent-to-treat population, median survival time was 7.7 months for patients treated with temozolomide and 6.4 months for those treated with DTIC (hazards ratio, 1.18; 95% confidence interval [CI], 0.92 to 1.52). Median PFS time was significantly longer in the temozolomide-treated group (1.9 months) than in the DTIC-treated group (1.5 months) (P = .012; hazards ratio, 1.37; 95% CI, 1.07 to 1.75) [3].

Clinical Trial
Storage

4°C, protect from light

Solvent & Solubility
In Vitro: 

DMSO : 6.42 mg/mL (35.24 mM; Need ultrasonic and warming)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4891 mL 27.4454 mL 54.8908 mL
5 mM 1.0978 mL 5.4891 mL 10.9782 mL
10 mM 0.5489 mL 2.7445 mL 5.4891 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

182.18

Formula

C₆H₁₀N₆O

CAS No.

4342-03-4

SMILES

O=C(C1=C(/N=N/N(C)C)NC=N1)N

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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Product Name:
Dacarbazine
Cat. No.:
HY-B0078
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Dacarbazine

Cat. No.: HY-B0078