4342-03-4
4342-03-4
Chemical Structure
Dacarbazine
Synonym(s): Imidazole Carboxamide
- CAS No.: 4342-03-4
- Formula:C6H10N6O
- Molecular Weight:182.18
IUPAC Name: (E)-5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide
InChIKey: FDKXTQMXEQVLRF-ZHACJKMWSA-N
SMILES: O=C(C1=C(/N=N/N(C)C)NC=N1)N
Biological Activity: Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC50 of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma[1][2][3][4][5].
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Dacarbazine | 99.71% | Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC50 of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma. | ||||||||||||||||||||
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Dacarbazine (Standard) | ≥98% | Dacarbazine (Standard) is the analytical standard of Dacarbazine. This product is intended for research and analytical applications. Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC50 of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma. | ||||||||||||||||||||
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Dacarbazine-d6 | Dacarbazine-d6 is the deuterium labeled Dacarbazine. Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent. It has significant activity against melanomas. | |||||||||||||||||||||
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Bredinin aglycone | 99.96% | Bredinin aglycone (5-Hydroxy-1H-imidazole-4-carboxamide) is a purine nucleotide analogue. Bredinin aglycone can be used to examine the efficiency of catalysts for the preparation of purine nucleotide analogues. | ||||||||||||||||||||
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MTIC | 98.83% | MTIC, the active metabolite of Temozolomide (TMZ), is a DNA alkylating agent. MTIC has antitumor activity . | ||||||||||||||||||||
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MTIC-d3 | MTIC-d3 is deuterium labeled MTIC. MTIC is the active metabolite of Temozolomide (TMZ). MITC has lower bioavailability in the brain compared with TMZ, because the agent’s permeability through biological barriers and tumor cell membranes affects bioavailability. MITC exhibits low affinity to biological membrane. | |||||||||||||||||||||
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5-Ureidoimidazole-4-carboxylic acid | 5-Ureidoimidazole-4-carboxylic acid is a nucleoside metabolite. | |||||||||||||||||||||
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5-Amino-3H-imidazole-4-carboxamide hydrochloride (Standard) | ≥98% | 5-Amino-3H-imidazole-4-carboxamide (hydrochloride) (Standard) is the analytical standard of 5-Amino-3H-imidazole-4-carboxamide hydrochloride (HY-41461A). This product is intended for research and analytical applications. 5-Amino-3H-imidazole-4-Carboxamide (AICA) hydrochloride is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular. | ||||||||||||||||||||
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5-Amino-3H-imidazole-4-Carboxamide (Standard) | ≥98% | 5-Amino-3H-imidazole-4-Carboxamide (Standard) is the analytical standard of 5-Amino-3H-imidazole-4-Carboxamide. This product is intended for research and analytical applications. 5-Amino-3H-imidazole-4-Carboxamide (AICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular. | ||||||||||||||||||||
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Dacarbazine hydrochloride | Dacarbazine hydrochloride is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine hydrochloride inhibits T and B lymphoblastic response, with IC50 values of 50 and 10 μg/mL, respectively. Dacarbazine hydrochloride can be used for the research of metastatic malignant melanoma. | |||||||||||||||||||||
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5-Amino-1H-imidazole-4-carboxylic acid | 5-Amino-1H-imidazole-4-carboxylic acid is a nucleoside metabolite. | |||||||||||||||||||||
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Ethyl 4-methyl-5-imidazole-carboxylate | Ethyl 4-methyl-5-imidazole-carboxylate (Emizco) is an imidazole ester derivative. Ethyl 4-methyl-5-imidazole-carboxylate is promising for research of metal-based anticancer agents. | |||||||||||||||||||||
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References
- [1]. Serrone, L., et al., Dacarbazine-based chemotherapy for metastatic melanoma: thirty-year experience overview. J Exp Clin Cancer Res, 2000. 19(1): p. 21-34. [Content Brief]
- [2]. Al-Badr AA, et al. Dacarbazine. Profiles Drug Subst Excip Relat Methodol. 2016;41:323-77. [Content Brief]
- [3]. Rojo JM, et al. Inhibition of T and B lymphoblastic response by mithramycin, dacarbazine, prospidium chloride and peptichemio. Chemotherapy. 1983;29(5):345-51. [Content Brief]
- [4]. Erdmann S, et al. Induced cross-resistance of BRAFV600E melanoma cells to standard chemotherapeutic dacarbazine after chronic PLX4032 treatment. Sci Rep. 2019 Jan 10;9(1):30. [Content Brief]
- [5]. Salvador D, et al. Combined Therapy with Dacarbazine and Hyperthermia Induces Cytotoxicity in A375 and MNT-1 Melanoma Cells. Int J Mol Sci. 2022 Mar 25;23(7):3586. [Content Brief]
