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  4. Dacarbazine hydrochloride

Dacarbazine hydrochloride  (Synonyms: Imidazole Carboxamide hydrochloride)

Cat. No.: HY-B0078B
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Dacarbazine hydrochloride is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine hydrochloride inhibits T and B lymphoblastic response, with IC50 values of 50 and 10 μg/mL, respectively. Dacarbazine hydrochloride can be used for the research of metastatic malignant melanoma.

For research use only. We do not sell to patients.

CAS No. : 17925-90-5

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Top Publications Citing Use of Products

    Dacarbazine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Apr 9;16(1):268.  [Abstract]

    Dacarbazine (20 mg/kg; i.p.; 20 d) reduced tumor growth rates and tumor sizes of melanoma xenograft mice.

    Dacarbazine hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Dec;11(48):e2408707.  [Abstract]

    Dacarbazine (DTIC) (500 µM; 72 h) reduced the diameter and metabolic activity of MCTs except monoculture tumoroids, especially the triples and quadruples, resulting in a decrease of approximately 32% and 28% in relative diameter, respectively, and caused a high number of apoptotic cells to detach from the main structure.

    Dacarbazine hydrochloride purchased from MedChemExpress. Usage Cited in: Nature. 2023 Jun;618(7964):374-382.  [Abstract]

    Dacarbazine (60 mg/kg; i.p.; every other day for 8 d) significantly reduced red blood cell (RBC), reticulocyte (RET), and hemoglobin (HGB) counts in PBS- or B16F10-CL-EVP-educated mice.

    Dacarbazine hydrochloride purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2023 Oct 19;21(1):383.  [Abstract]

    Dacarbazine (DAC) (5 mg/kg; i.v.; once every three days for 3 times) caused significant cell necrosis and nucleopaenia in tumors of B16F10 tumor-bearing mice.

    Dacarbazine hydrochloride purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2023 Oct 19;21(1):383.  [Abstract]

    Dacarbazine (DAC) (5 mg/kg; i.v.; once every three days for 3 times) significantly inhibited the growth of subcutaneous B16F10 melanoma xenografts in C57BL/6 mice.

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    Description

    Dacarbazine hydrochloride is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine hydrochloride inhibits T and B lymphoblastic response, with IC50 values of 50 and 10 μg/mL, respectively. Dacarbazine hydrochloride can be used for the research of metastatic malignant melanoma[1][2].

    Molecular Weight

    218.64

    Formula

    C6H11ClN6O
    CAS No.
    SMILES

    O=C(C1=C(/N=N/N(C)C)NC=N1)N.[H]Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Dacarbazine hydrochloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Dacarbazine17925-90-5Imidazole CarboxamideAntibioticT cellB cellmetastatic malignant melanomaantineoplasticInhibitorinhibitorinhibit

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