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Dacarbazine hydrochloride

(Synonyms: Imidazole Carboxamide hydrochloride)
16 Cited Publications
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Based on 16 publication(s) in Google Scholar

Dacarbazine hydrochloride is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine hydrochloride inhibits T and B lymphoblastic response, with IC50 values of 50 and 10 μg/mL, respectively. Dacarbazine hydrochloride can be used for the research of metastatic malignant melanoma.

For research use only. We do not sell to patients.

  • CAS No.: 17925-90-5
  • Formula: C6H11ClN6O
  • Molecular Weight:218.64
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Dacarbazine hydrochloride Chemical Structure
    Dacarbazine hydrochloride Chemical Structure
  • Experimental Validation Results for Dacarbazine hydrochloride
  • Experimental Validation Results for Dacarbazine hydrochloride
  • Experimental Validation Results for Dacarbazine hydrochloride
  • Experimental Validation Results for Dacarbazine hydrochloride
  • Experimental Validation Results for Dacarbazine hydrochloride
CAS No.: 17925-90-5
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Dacarbazine hydrochloride Chemical Structure
    Dacarbazine hydrochloride Chemical Structure
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    Dacarbazine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Apr 9;16(1):268. [Abstract]

    Customer Validation
     Dacarbazine (20 mg/kg; i.p.; 20 d) reduced tumor growth rates and tumor sizes of melanoma xenograft mice.

  • 1/16

    Dacarbazine hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Dec;11(48):e2408707. [Abstract]

    Customer Validation
     Dacarbazine (DTIC) (500 µM; 72 h) reduced the diameter and metabolic activity of MCTs except monoculture tumoroids, especially the triples and quadruples, resulting in a decrease of approximately 32% and 28% in relative diameter, respectively, and caused a high number of apoptotic cells to detach from the main structure.

  • 1/16

    Dacarbazine hydrochloride purchased from MedChemExpress. Usage Cited in: Nature. 2023 Jun;618(7964):374-382. [Abstract]

    Customer Validation
     Dacarbazine (60 mg/kg; i.p.; every other day for 8 d) significantly reduced red blood cell (RBC), reticulocyte (RET), and hemoglobin (HGB) counts in PBS- or B16F10-CL-EVP-educated mice.

  • 1/16

    Dacarbazine hydrochloride purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2023 Oct 19;21(1):383. [Abstract]

    Customer Validation
     Dacarbazine (DAC) (5 mg/kg; i.v.; once every three days for 3 times) significantly inhibited the growth of subcutaneous B16F10 melanoma xenografts in C57BL/6 mice.

  • 1/16

    Dacarbazine hydrochloride purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2023 Oct 19;21(1):383. [Abstract]

    Customer Validation
     H&E staining of tumors in each group at the end of treatment. The results showed that Dacarbazine (DAC) (5 mg/kg; i.v.; once every three days for 3 times) caused significant cell necrosis and nucleopaenia in tumors of B16F10 tumor-bearing mice. Scale bar, 100 μm.

  • Dacarbazine hydrochloride