1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. Etilevodopa

Etilevodopa (Synonyms: L-DOPA ethyl ester; Levodopa ethyl ester)

Cat. No.: HY-116016
Handling Instructions

Etilevodopa (L-Dopa ethyl ester), an ethyl-ester prodrug of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable prodrug as it facilitates CNS penetration and delivers dopamine.

For research use only. We do not sell to patients.

Etilevodopa Chemical Structure

Etilevodopa Chemical Structure

CAS No. : 37178-37-3

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Description

Etilevodopa (L-Dopa ethyl ester), an ethyl-ester prodrug of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable prodrug as it facilitates CNS penetration and delivers dopamine[1][2][3].

In Vitro

Etilevodopa (L-Dopa ethyl ester) passes unchanged through the stomach to the duodenum, where it is rapidly hydrolyzed by local esterases to Levodopa and ethanol, and is subsequently absorbed into the blood stream as Levodopa[1].
Compared with standard Levodopa, Etilevodopa has greater solubility in the stomach, faster passage to the small intestine, and a shortened time to maximum Levodopa concentration[2].

Molecular Weight

225.24

Formula

C₁₁H₁₅NO₄

CAS No.

37178-37-3

SMILES

N[[email protected]](C(OCC)=O)CC1=CC=C(C(O)=C1)O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

EtilevodopaL-DOPA ethyl esterLevodopa ethyl esterDrug MetaboliteprodrugesterasesgastrointestinaltractParkinsondiseasemotorfluctuations,CNSpenetrationInhibitorinhibitorinhibit

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Etilevodopa
Cat. No.:
HY-116016
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