1. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. Dopamine Receptor
    Drug Metabolite
  3. Etilevodopa hydrochloride

Etilevodopa hydrochloride (Synonyms: L-DOPA ethyl ester hydrochloride; Levodopa ethyl ester hydrochloride)

Cat. No.: HY-116016A
Handling Instructions

Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester prodrug of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable prodrug as it facilitates CNS penetration and delivers dopamine.

For research use only. We do not sell to patients.

Etilevodopa hydrochloride Chemical Structure

Etilevodopa hydrochloride Chemical Structure

CAS No. : 39740-30-2

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10 mM * 1  mL in Water USD 440 In-stock
Estimated Time of Arrival: December 31
5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
10 mg USD 670 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester prodrug of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable prodrug as it facilitates CNS penetration and delivers dopamine[1][2][3].

In Vitro

Etilevodopa (L-Dopa ethyl ester) hydrochloride passes unchanged through the stomach to the duodenum, where it is rapidly hydrolyzed by local esterases to Levodopa and ethanol, and is subsequently absorbed into the blood stream as Levodopa[1].
Compared with standard Levodopa, Etilevodopa hydrochloride has greater solubility in the stomach, faster passage to the small intestine, and a shortened time to maximum Levodopa concentration[2].

Molecular Weight

261.70

Formula

C₁₁H₁₆ClNO₄

CAS No.

39740-30-2

SMILES

N[[email protected]@H](CC1=CC=C(O)C(O)=C1)C(OCC)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (477.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8212 mL 19.1058 mL 38.2117 mL
5 mM 0.7642 mL 3.8212 mL 7.6423 mL
10 mM 0.3821 mL 1.9106 mL 3.8212 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

EtilevodopaL-DOPA ethyl esterLevodopa ethyl esterDopamine ReceptorDrug MetaboliteprodrugesterasesgastrointestinaltractParkinsondiseasemotorfluctuationsCNSpenetrationInhibitorinhibitorinhibit

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Product name:
Etilevodopa hydrochloride
Cat. No.:
HY-116016A
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