1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. iGluR
  3. cis-Piperidine-2,3-dicarboxylic acid

Cis-piperidine-2,3-dicarboxylic acid is a non-specific antagonist of NMDA, AMPA and kainate ionotropic receptors and a partial agonist for NMDA receptors. Cis-piperidine-2,3-dicarboxylic acid can be used in blocking general excitatory synaptic transmissions.

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cis-Piperidine-2,3-dicarboxylic acid Chemical Structure

cis-Piperidine-2,3-dicarboxylic acid Chemical Structure

CAS No. : 46026-75-9

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10 mg USD 40 In-stock
25 mg USD 80 In-stock
50 mg USD 130 In-stock
100 mg USD 208 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Cis-piperidine-2,3-dicarboxylic acid is a non-specific antagonist of NMDA, AMPA and kainate ionotropic receptors and a partial agonist for NMDA receptors. Cis-piperidine-2,3-dicarboxylic acid can be used in blocking general excitatory synaptic transmissions[1].

Molecular Weight

173.17

Formula

C7H11NO4

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)[C@H]1NCCC[C@H]1C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (577.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7747 mL 28.8734 mL 57.7467 mL
5 mM 1.1549 mL 5.7747 mL 11.5493 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.7747 mL 28.8734 mL 57.7467 mL 144.3668 mL
5 mM 1.1549 mL 5.7747 mL 11.5493 mL 28.8734 mL
10 mM 0.5775 mL 2.8873 mL 5.7747 mL 14.4367 mL
15 mM 0.3850 mL 1.9249 mL 3.8498 mL 9.6245 mL
20 mM 0.2887 mL 1.4437 mL 2.8873 mL 7.2183 mL
25 mM 0.2310 mL 1.1549 mL 2.3099 mL 5.7747 mL
30 mM 0.1925 mL 0.9624 mL 1.9249 mL 4.8122 mL
40 mM 0.1444 mL 0.7218 mL 1.4437 mL 3.6092 mL
50 mM 0.1155 mL 0.5775 mL 1.1549 mL 2.8873 mL
60 mM 0.0962 mL 0.4812 mL 0.9624 mL 2.4061 mL
80 mM 0.0722 mL 0.3609 mL 0.7218 mL 1.8046 mL
100 mM 0.0577 mL 0.2887 mL 0.5775 mL 1.4437 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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cis-Piperidine-2,3-dicarboxylic acid Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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cis-Piperidine-2,3-dicarboxylic acid
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