1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. S 18986

S 18986 

Cat. No.: HY-10936 Purity: >99.0%
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S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests.

For research use only. We do not sell to patients.

S 18986 Chemical Structure

S 18986 Chemical Structure

CAS No. : 175340-20-2

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 271 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 925 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests[1][2].

In Vivo

S 18986 is robust memory-enhancing effects in middle-aged animals compared with aged ones. S 18986 shows antiamnesic properties in middle-aged rodents in spatial memory models [1].
S 18986 (5-50 mg/kg; i.p.) significantly increases both the induction and the maintenance of 4 and 20 bursts tetanus-evoked potentiation[1].

Animal Model: Middle-aged (14-15-months-old) mice[1]
Dosage: 0.3, 1, and 10 mg/kg
Administration: p.o.
Result: Showed antiamnesic properties in middle-aged rodents.
Clinical Trial
Molecular Weight

224.28

Formula

C₁₀H₁₂N₂O₂S

CAS No.

175340-20-2

SMILES

O=S1(C2=CC=CC=C2N3[[email protected]@](CCC3)([H])N1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
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Keywords:

S 18986S18986S-18986iGluRIonotropic glutamate receptorsbrainpenetrantcognitiverodentsmemoryglutamateneuroprotectionantiamnesicInhibitorinhibitorinhibit

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S 18986
Cat. No.:
HY-10936
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