2-Methylthio-ATP tetrasodium
2-Methylthio-ATP tetrasodium is a non-specific P2-receptor agonist. 2-Methylthio-ATP tetrasodium causes noncompetitive inhibition of ADP-induced human platelet aggregation.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 100020-57-3
- Formula: C11H14N5Na4O13P3S
- Molecular Weight:641.20
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All P2X Receptor Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
4.5 nM
Compound: 13b
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Agonists activity was evaluated by release of [Ca2+] release of HEK 293 cells stably transfected with rat-brain P2Y purinoceptor 1 (P2Y1-R)
Agonists activity was evaluated by release of [Ca2+] release of HEK 293 cells stably transfected with rat-brain P2Y purinoceptor 1 (P2Y1-R)
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[PMID: 12431066] |
Chemical Information
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CAS No. 100020-57-3
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Appearance Solid
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Molecular Weight 641.20
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Formula C11H14N5Na4O13P3S
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Color White to off-white
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SMILES
O[C@H]([C@@H]1O)[C@](O[C@@H]1CO[P](O[P](O[P](O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)([H])N2C3=NC(SC)=NC(N)=C3N=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 50 mg/mL (77.98 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. N. J. Cusack, et al. Specific but noncompetitive inhibition by 2-alkylthio analogues of adenosine 5'-monophosphate and adenosine 5'-triphosphate of human platelet aggregation induced by adenosine 5'-diphosphate. Br J Pharmacol. 1982 Feb; 75(2): 397–400. [Content Brief]
[2]. S G Hamilton, et al. The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. Br J Pharmacol. 1999 Jan;126(1):326-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.5596 mL | 7.7979 mL | 15.5958 mL | 38.9894 mL |
| 5 mM | 0.3119 mL | 1.5596 mL | 3.1192 mL | 7.7979 mL | |
| 10 mM | 0.1560 mL | 0.7798 mL | 1.5596 mL | 3.8989 mL | |
| 15 mM | 0.1040 mL | 0.5199 mL | 1.0397 mL | 2.5993 mL | |
| 20 mM | 0.0780 mL | 0.3899 mL | 0.7798 mL | 1.9495 mL | |
| 25 mM | 0.0624 mL | 0.3119 mL | 0.6238 mL | 1.5596 mL | |
| 30 mM | 0.0520 mL | 0.2599 mL | 0.5199 mL | 1.2996 mL | |
| 40 mM | 0.0390 mL | 0.1949 mL | 0.3899 mL | 0.9747 mL | |
| 50 mM | 0.0312 mL | 0.1560 mL | 0.3119 mL | 0.7798 mL | |
| 60 mM | 0.0260 mL | 0.1300 mL | 0.2599 mL | 0.6498 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
2-Methylthio-ATP tetrasodium Related Classifications
HY-101370 Related Classifications
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