Atherosperminine
Atherosperminine (Atherospermine) is a phosphodiesterase inhibitor. Atherosperminine inhibits growth of chloroquine-resistant Plasmodium falciparum. Atherosperminine scavenges DPPH free radicals, exhibits ferric reducing power, and chelates metal ions. Atherosperminine can be used for the research of malaria.
For research use only. We do not sell to patients.
- CAS No.: 5531-98-6
- Formula: C20H23NO2
- Molecular Weight:309.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Biological Activity
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Plasmodium |
Atherosperminine (25-100 μM; 15 min) exerts concentration-dependent, non-specific inhibition of contractions induced by multiple agonists in isolated guinea-pig trachealis[1].
Atherosperminine (25-500 μM) induces concentration-dependent relaxation of carbachol-precontracted isolated guinea-pig trachealis with an EC50 of 117.8 μM, an effect independent of β-adrenoceptors, ATP-sensitive K+ channels, and tracheal epithelium[1].
Atherosperminine (25-50 μM; 15 min) potentiates forskolin-induced relaxation of carbachol-precontracted isolated guinea-pig trachealis by 2.4-fold and 5.0-fold, respectively[1].
Atherosperminine (50-250 μM; 5 min) concentration-dependently increases cAMP content in isolated guinea-pig trachealis without altering cGMP content[1].
Atherosperminine (25-2500 μM; 30 min) potently inhibits cAMP phosphodiesterase (IC50 = 56.8 μM) and weakly inhibits cGMP phosphodiesterase (IC50 = 693.3 μM) in guinea-pig trachealis homogenate[1].
Atherosperminine exhibits antioxidant activity, with an IC50 value of 54.53 μg/mL for DPPH radical scavenging, and demonstrates metal chelating activity with an IC50 of 42.87 μg/mL[2].
Atherosperminine exhibits antiplasmodial activity, with an IC50 value of 5.80 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 5531-98-6
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Molecular Weight 309.40
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Formula C20H23NO2
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SMILES
CN(C)CCC1=C2C=CC3=CC=CC=C3C2=C(OC)C(OC)=C1
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Synonyms
Atherospermine
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ayu Afiqah Nasrullah, et al. Antiplasmodial Alkaloids from the Bark of Cryptocarya nigra (Lauraceae). Molecules. 2013 Jul; 18(7): 8009–8017. [Content Brief]
[2]. C H Lin, et al. The relaxant actions on guinea-pig trachealis of atherosperminine isolated from Fissistigma. Eur J Pharmacol. 1993 Jun 11;237(1):109-16. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Atherosperminine Related Classifications
HY-N7648 Related Classifications
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