Atherosperminine  (Synonyms: Atherospermine)

Atherosperminine (Atherospermine) is a phosphodiesterase inhibitor. Atherosperminine inhibits growth of chloroquine-resistant Plasmodium falciparum. Atherosperminine scavenges DPPH free radicals, exhibits ferric reducing power, and chelates metal ions. Atherosperminine can be used for the research of malaria^[1][2].

Atherosperminine (25-100 μM; 15 min) exerts concentration-dependent, non-specific inhibition of contractions induced by multiple agonists in isolated guinea-pig trachealis^[1].
Atherosperminine (25-500 μM) induces concentration-dependent relaxation of carbachol-precontracted isolated guinea-pig trachealis with an EC₅₀ of 117.8 μM, an effect independent of β-adrenoceptors, ATP-sensitive K⁺ channels, and tracheal epithelium^[1].
Atherosperminine (25-50 μM; 15 min) potentiates forskolin-induced relaxation of carbachol-precontracted isolated guinea-pig trachealis by 2.4-fold and 5.0-fold, respectively^[1].
Atherosperminine (50-250 μM; 5 min) concentration-dependently increases cAMP content in isolated guinea-pig trachealis without altering cGMP content^[1].
Atherosperminine (25-2500 μM; 30 min) potently inhibits cAMP phosphodiesterase (IC₅₀ = 56.8 μM) and weakly inhibits cGMP phosphodiesterase (IC₅₀ = 693.3 μM) in guinea-pig trachealis homogenate^[1].
Atherosperminine exhibits antioxidant activity, with an IC₅₀ value of 54.53 μg/mL for DPPH radical scavenging, and demonstrates metal chelating activity with an IC₅₀ of 42.87 μg/mL^[2].
Atherosperminine exhibits antiplasmodial activity, with an IC₅₀ value of 5.80 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

309.40

C₂₀H₂₃NO₂

5531-98-6

CN(C)CCC1=C2C=CC3=CC=CC=C3C2=C(OC)C(OC)=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ayu Afiqah Nasrullah, et al. Antiplasmodial Alkaloids from the Bark of Cryptocarya nigra (Lauraceae). Molecules. 2013 Jul; 18(7): 8009–8017.  [Content Brief]

  [2]. C H Lin, et al. The relaxant actions on guinea-pig trachealis of atherosperminine isolated from Fissistigma. Eur J Pharmacol. 1993 Jun 11;237(1):109-16.  [Content Brief]