Atherosperminine hydrochloride  (Synonyms: Atherospermine hydrochloride)

Atherosperminine (Atherospermine) hydrochloride is a phosphodiesterase inhibitor. Atherosperminine hydrochloride inhibits growth of chloroquine-resistant Plasmodium falciparum. Atherosperminine hydrochloride scavenges DPPH free radicals, exhibits ferric reducing power, and chelates metal ions. Atherosperminine hydrochloride can be used for the research of malaria^[1][2].

Atherosperminine (25-100 μM; 15 min) hydrochloride exerts concentration-dependent, non-specific inhibition of contractions induced by multiple agonists in isolated guinea-pig trachealis^[1].
Atherosperminine (25-500 μM) hydrochloride induces concentration-dependent relaxation of carbachol-precontracted isolated guinea-pig trachealis with an EC₅₀ of 117.8 μM, an effect independent of β-adrenoceptors, ATP-sensitive K⁺ channels, and tracheal epithelium^[1].
Atherosperminine (25-50 μM; 15 min) hydrochloride potentiates forskolin-induced relaxation of carbachol-precontracted isolated guinea-pig trachealis by 2.4-fold and 5.0-fold, respectively^[1].
Atherosperminine (50-250 μM; 5 min) hydrochloride concentration-dependently increases cAMP content in isolated guinea-pig trachealis without altering cGMP content^[1].
Atherosperminine (25-2500 μM; 30 min) hydrochloride potently inhibits cAMP phosphodiesterase (IC₅₀ = 56.8 μM) and weakly inhibits cGMP phosphodiesterase (IC₅₀ = 693.3 μM) in guinea-pig trachealis homogenate^[1].
Atherosperminine hydrochloride exhibits antioxidant activity, with an IC₅₀ value of 54.53 μg/mL for DPPH radical scavenging, and demonstrates metal chelating activity with an IC₅₀ of 42.87 μg/mL^[2].
Atherosperminine hydrochloride exhibits antiplasmodial activity, with an IC₅₀ value of 5.80 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

345.86

C₂₀H₂₄ClNO₂

54749-97-2

CN(C)CCC1=C2C=CC3=CC=CC=C3C2=C(OC)C(OC)=C1.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Nasrullah AA, et al. Antiplasmodial alkaloids from the bark of Cryptocarya nigra (Lauraceae). Molecules. 2013;18(7):8009-8017. Published 2013 Jul 8.  [Content Brief]

  [2]. Lin CH, et al. The relaxant actions on guinea-pig trachealis of atherosperminine isolated from Fissistigma glaucescens. Eur J Pharmacol. 1993;237(1):109-116.  [Content Brief]