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Results for "

m-cell

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (9) Aldehyde Dehydrogenase (ALDH) (1) AMPK (2) Anaplastic lymphoma kinase (ALK) (2) Antibiotic (2) AP-1 (1) APC (1) Apoptosis (64) ATM/ATR (2) Aurora Kinase (2) Autophagy (7) Bacterial (1) Bcl-2 Family (10) c-Met/HGFR (1) c-Myc (7) Caspase (15) CDK (9) COX (3) Cyclic GMP-AMP Synthase (1) Cyclin G-associated Kinase (GAK) (1) Dipeptidyl Peptidase (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (6) EGFR (3) Endogenous Metabolite (3) Environmental Pollutants (1) Epigenetic Reader Domain (1) ERK (8) FAK (1) Ferroptosis (1) FOXO (2) Fungal (1) G-quadruplex (1) GSK-3 (1) HDAC (4) Hedgehog (1) HIF/HIF Prolyl-Hydroxylase (2) HSP (2) Hsp-targeting Chimeras (1) Interleukin Related (3) Isotope-Labeled Compounds (1) JAK (5) JNK (6) Keap1-Nrf2 (4) Lipoxygenase (2) MDM-2/p53 (4) Microtubule/Tubulin (17) Mitochondrial Metabolism (2) MMP (1) mTOR (1) NF-κB (8) NOD-like Receptor (NLR) (1) P-glycoprotein (1) p38 MAPK (6) PANoptosis (1) Parasite (1) PARP (3) PDGFR (1) Phosphatase (3) PI3K (9) Polo-like Kinase (PLK) (1) PROTACs (2) Proteasome (1) PTEN (1) Pyroptosis (2) Pyruvate Kinase (2) Ras (1) Reactive Oxygen Species (ROS) (9) Reference Standards (5) ROCK (1) Ser/Thr Kinase (1) SHP2 (1) STAT (6) STING (3) TGF-beta/Smad (1) TNF Receptor (2) Topoisomerase (4) TrxR (1) Wee1 (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (84) Cardiovascular Disease (4) Infection (6) Inflammation/Immunology (10) Metabolic Disease (9) Neurological Disease (9)

By Targets:

Akt (9)

Aldehyde Dehydrogenase (ALDH) (1)

AMPK (2)

Anaplastic lymphoma kinase (ALK) (2)

Antibiotic (2)

AP-1 (1)

APC (1)

Apoptosis (64)

ATM/ATR (2)

Aurora Kinase (2)

Autophagy (7)

Bacterial (1)

Bcl-2 Family (10)

c-Met/HGFR (1)

c-Myc (7)

Caspase (15)

CDK (9)

COX (3)

Cyclic GMP-AMP Synthase (1)

Cyclin G-associated Kinase (GAK) (1)

Dipeptidyl Peptidase (1)

DNA Alkylator/Crosslinker (2)

DNA/RNA Synthesis (6)

EGFR (3)

Endogenous Metabolite (3)

Environmental Pollutants (1)

Epigenetic Reader Domain (1)

ERK (8)

FAK (1)

Ferroptosis (1)

FOXO (2)

Fungal (1)

G-quadruplex (1)

GSK-3 (1)

HDAC (4)

Hedgehog (1)

HIF/HIF Prolyl-Hydroxylase (2)

HSP (2)

Hsp-targeting Chimeras (1)

Interleukin Related (3)

Isotope-Labeled Compounds (1)

JAK (5)

JNK (6)

Keap1-Nrf2 (4)

Lipoxygenase (2)

MDM-2/p53 (4)

Microtubule/Tubulin (17)

Mitochondrial Metabolism (2)

MMP (1)

mTOR (1)

NF-κB (8)

NOD-like Receptor (NLR) (1)

P-glycoprotein (1)

p38 MAPK (6)

PANoptosis (1)

Parasite (1)

PARP (3)

PDGFR (1)

Phosphatase (3)

PI3K (9)

Polo-like Kinase (PLK) (1)

PROTACs (2)

Proteasome (1)

PTEN (1)

Pyroptosis (2)

Pyruvate Kinase (2)

Ras (1)

Reactive Oxygen Species (ROS) (9)

Reference Standards (5)

ROCK (1)

Ser/Thr Kinase (1)

SHP2 (1)

STAT (6)

STING (3)

TGF-beta/Smad (1)

TNF Receptor (2)

Topoisomerase (4)

TrxR (1)

Wee1 (2)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (84)

Cardiovascular Disease (4)

Infection (6)

Inflammation/Immunology (10)

Metabolic Disease (9)

Neurological Disease (9)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13902

Berzosertib Maximum Cited Publications 24 Publications Verification VE-822; VX-970; M6620	ATM/ATR Apoptosis STING Caspase	Infection Metabolic Disease Cancer
Berzosertib (VE-822) is an orally active, CNS-penetrant, and selective ATR kinase inhibitor. Berzosertib blocks ATR kinase activity, abrogates G₂/M cell cycle checkpoint, impairs DNA damage repair. Berzosertib induces apoptosis, inhibnits conlony migration, inhibits cell proliferation, and activates cGAS-STING axes in cancer cells. Berzosertib can be used for the research of cancers, such as head and neck squamous cell carcinoma, and colorectal cancer .

HY-17583

Griseofulvin 1 Publications Verification	Environmental Pollutants Antibiotic Apoptosis Fungal Endogenous Metabolite Bcl-2 Family Caspase Microtubule/Tubulin	Infection Cardiovascular Disease Cancer
Griseofulvin is an orally active antifungal antibiotic with antitumor activity. Griseofulvin induces apoptosis and G2/M cell cycle arrest in cancer cells. Griseofulvin also has cardiovascular modulatory activity, reducing angina pectoris, relieving hand artery spasm associated with onychomycosis, and peripheral vascular diseases such as shoulder-hand syndrome .

HY-N0816

Polyphyllin VI Maximum Cited Publications 6 Publications Verification	Apoptosis Pyroptosis	Cancer
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer .

HY-W674241

4-Ethylphenyl sulfate	Endogenous Metabolite Apoptosis Bcl-2 Family Reactive Oxygen Species (ROS)	Neurological Disease Cancer
4-Ethylphenyl sulfate is an orally active and brain-penetrant gut microbial metabolite. 4-Ethylphenyl sulfate downregulates Bcl2 expression, upregulates Bax expression, and induces cancer cell apoptosis via the endogenous apoptotic pathway. 4-Ethylphenyl sulfate induces G2/M cell cycle arrest and reactive oxygen species (ROS) production. 4-Ethylphenyl sulfate impairs oligodendrocyte maturation, reduces oligodendrocyte-neuron interactions, decreases axonal myelination levels, and shifts the oligodendrocyte population toward immature precursor cells. 4-Ethylphenyl sulfate alters brain region-specific neural activity and functional connectivity in mice, and correlates with anxiety-like behaviors in mice .

HY-N0493

Pectolinarigenin 2 Publications Verification	COX Lipoxygenase NF-κB p38 MAPK ERK HIF/HIF Prolyl-Hydroxylase Keap1-Nrf2 PI3K Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Pectolinarigenin is an orally active dual inhibitor of COX-2/5-LOX with anti-inflammatory, antioxidant, antitumor and neuroprotective activities. Pectolinarigenin exerts neuroprotective and anti-inflammatory effects on astrocyte inflammation via the NFκB and MAPK pathways. Pectolinarigenin inhibits LPS-induced phosphorylation of ERK1/2, N-FκB and p38MAPK, directly inhibits the enzymatic activity or binding of COX-2, 5-LOX and HIF-1α, and reduces the level of XIAP. Pectolinarigenin modifies Keap1 to promote nuclear accumulation of Nrf2, induces ARE-mediated antioxidant enzyme expression, and possesses direct free radical scavenging activity. Pectolinarigenin reduces the release of NO, proinflammatory mediators and leukotrienes, and increases the level of IL-10. Pectolinarigenin induces G₂/M cell cycle arrest, apoptosis (Apoptosis) and autophagy (Autophagy) via the PI3K/AKT/mTOR signaling pathway. Pectolinarigenin reduces renal crystal deposition and inhibits melanin synthesis. Pectolinarigenin inhibits inflammation and alleviates allergy in mouse models of inflammation. Pectolinarigenin alleviates renal injury, inflammation and oxidative stress in mice by inhibiting HIF-1α activity. Pectolinarigenin can be used for the research of neurodegenerative diseases, inflammatory/allergic diseases, calcium oxalate nephrocalcinosis, gastric cancer, melasma, post-inflammatory diseases and chloasma .

HY-137497

KRAS inhibitor-9	Ras Apoptosis	Cancer
KRAS inhibitor-9, a potent KRAS inhibitor (K_d=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells .

HY-N0863

Methyl protodioscin NSC-698790; Smilax saponin B	Bcl-2 Family Apoptosis Akt c-Myc ERK p38 MAPK JNK FOXO	Cancer
Methyl protodioscin (NSC-698790; Smilax saponin B) is a multi-target, selective, steroidal diglycoside inhibitor with antitumor activity that induces cell cycle arrest. The mechanism of action of Methyl protodioscin is complex, involving the induction of G2/M cell cycle arrest, regulation of the Bcl-2/Bax apoptotic pathway, inhibition of the Akt1/c-Myc axis and MAPK/ERK signaling, while simultaneously downregulating ADAM15 and inducing FOXO1 to reduce cholesterol synthesis. It also inhibits the JNK/c-Jun pathway, reducing the production of inflammatory factors (IL-6, TNF-α). Methyl protodioscin exhibits significant antitumor (inhibiting proliferation, migration, invasion, and inducing apoptosis), anti-inflammatory, and anti-restenosis activities. Methyl protodioscin can be used in research on lung cancer, prostate cancer, pancreatic cancer, and other tumors, as well as inflammatory diseases such as airway inflammation and enteritis .

HY-W013724

Inosine-5'-diphosphate disodium IDP disodium; Inosine-5'-diphosphoric acid disodium	c-Myc Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Inosine-5'-diphosphate disodium (IDP disodium) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate disodium has a superior bond capacity on GDP-binding pocket of NM23-H2 (K_D: 5.0 μM). Inosine-5'-diphosphate disodium abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate disodium has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate disodium can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research .

HY-42484

ER-076349 Eribulin intermediate	Microtubule/Tubulin	Cancer
ER-076349 (Eribulin intermediate) is an inhibitor of tubulin polymerization, induces G2-M cell cycle arrest, and disrupts mitotic spindles. ER-076349 inhibits cancer cell growth, and inhibits tumor growth in several human tumor xenografts. ER-076349 is an analog of Halichondrin B .

HY-N2447

Amarogentin 2 Publications Verification	AMPK Apoptosis	Metabolic Disease Cancer
Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK .

HY-16350

BOLD-100 1 Publications Verification NKP-1339; IT-139; KP-1339	DNA/RNA Synthesis Apoptosis	Cancer
BOLD-100 (NKP-1339; IT-139) is the first-in-class ruthenium-based anticancer agent in development against solid cancer with limited side effects. BOLD-100 induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. BOLD-100 has a high tumor targeting potential, strongly binds to serum proteins such as albumin and transferrin and activates in the reductive tumor milieu .

HY-N3011

Iridin	PI3K Akt Pyruvate Kinase JAK STAT NF-κB Apoptosis Reactive Oxygen Species (ROS)	Metabolic Disease Inflammation/Immunology Cancer
Iridin is an orally active natural isoflavone. Iridin inhibits the PI3K/AKT and PKM2 signaling pathways, and downregulates the JAK/STAT and NF-κB pathways. Iridin induces Fas-mediated extrinsic apoptosis, G2/M cell cycle arrest, and inhibits cell proliferation. Iridin reduces inflammation, inhibits ROS production, suppresses glycolysis, and also exhibits antioxidant and antidiabetic activities. Iridin can be used in research related to gastric cancer and acute lung injury .

HY-N7225

Yuanhuacine 1 Publications Verification Gnidilatidin	DNA/RNA Synthesis	Cancer
Yuanhuacine (Gnidilatidin), a diterpene from Daphne genkwa, is an effective and highly selective inhibitor of the basal-like 2 (BL2) subtype of TNBC. Yuanhuacine can induce G2/M cell cycle arrest and has broad anti-tumor activity. Yuanhuacine is an orally active DNA damaging agent .

HY-B0294S

Flubendazole-d3	Parasite Microtubule/Tubulin Apoptosis	Infection Cancer
Flubendazole-d₃ is the deuterium labeled Flubendazole. Flubendazole is a safe and efficacious anthelmintic agent, which is widely used for anthelmintic to human, rodents and ruminants. Flubendazole exerts anticancer activities by mechanisms including inhibition of microtubule function. Flubendazole induces p53-mediated apoptosis and arrests G2/M cell cycle .

HY-121607

INI-43 1 Publications Verification	AP-1 Apoptosis	Cancer
INI-43 is an inhibitor of Kpnβ1, interfering with the nuclear localization of Kpnβ1 and known Kpnβ1 cargo proteins, NFAT, NFκB, AP-1, and NFY. INI-43 can inhibit the proliferation of cancer cells, cause G₂-M cell cycle arrest in cancer cells, and induce the intrinsic apoptosis pathway .

HY-119357

TN-16	Microtubule/Tubulin Apoptosis Autophagy	Neurological Disease Cancer
TN-16 is a Microtubule polymerization inhibitor. TN-16 induces G₂/M cell cycle arrest, metaphase mitotic arrest and Apoptotic cell death in cells, and blocks late Autophagic flux by inhibiting autophagosome-lysosome fusion. TN-16 suppresses tumor growth in syngeneic mouse breast cancer models. TN-16 can be used in research related to neuroblastoma, cervical cancer, breast cancer and other tumors .

HY-173320

HEMTAC WEE1 degrader-1	Hsp-targeting Chimeras Wee1 HSP	Cancer
HEMTAC WEE1 degrader-1 is a HSP90-mediated targeting chimera (HEMTAC) degrader of WEE1 (HSP90 enzyme inhibitory activity is IC₅₀: 16.76 nM). HEMTAC WEE1 degrader-1 promotes the ubiquitination and degradation of WEE1. HEMTAC WEE1 degrader-1 blocks the G2/M cell cycle. HEMTAC WEE1 degrader-1 has anticancer activity in acute myeloid leukemia (AML) patient-derived xenograft (PDX) models. HEMTAC WEE1 degrader-1 can be used in AML research. (Pink: HSP90 binder; Blue: WEE1 ligand; Black: linker) .

HY-149101

Inosine-5'-diphosphate IDP; Inosine-5'-diphosphoric acid	c-Myc Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Inosine-5'-diphosphate (IDP) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate has a superior bond capacity on GDP-binding pocket of NM23-H2 (K_D: 5.0 μM). Inosine-5'-diphosphate abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research .

HY-155874

ZNL-05-044	CDK	Cancer
ZNL-05-044 is a CDK11 inhibitor with an IC₅₀s of 0.23 μM and 0.27 μM against CDK11A and CDK11B, respectively (NanoBRET assay). ZNL-05-044 leads to G2/M cell cycle arrest and impairs RNA splicing .

HY-112440

HZX-02-059 Methuosis inducer 1	Microtubule/Tubulin NF-κB MDM-2/p53 PI3K Akt c-Myc mTOR Autophagy	Cancer
HZX-02-059 is an allosteric inhibitor of PIKFYVE, and a methuosis inducer. HZX-02-059 disrupts the PIKfyve/TFEB axis, suppresses tubulin polymerization, reduces phosphorylated mTOR levels, downregulates p53, PI3K/AKT, c-Myc, and NF-κB pathways. HZX-02-059 induces G₂/M cell cycle arrest, apoptosis, and inhibits cancer cell proliferation. HZX-02-059 can be used for the research of lymphoma, double-hit lymphoma, and B-cell acute lymphoblastic leukemia .

HY-N7695

Physalin B	Apoptosis NF-κB NOD-like Receptor (NLR) STAT PI3K Akt Hedgehog GSK-3 p38 MAPK ERK JNK Keap1-Nrf2 Reactive Oxygen Species (ROS) Autophagy	Metabolic Disease Inflammation/Immunology Cancer
Physalin B is an orally active anti-inflammatory and anticancer agent. Physalin B can be isolated from Physalis alkekengi L. var. Franchetii. Physalin B inhibits the activation of the NF-κB, NLRP3 inflammasome, STAT3, PI3K/Akt and Hedgehog signaling pathways, regulates the phosphorylation levels of GSK-3β, p38 MAPK, ERK1/2 and JNK, and promotes the nuclear translocation of NRF2. Physalin B reduces the levels of pro-inflammatory cytokines and factors, induces mitochondrial reactive oxygen species (mito-ROS) production, Apoptosis, G2/M cell cycle arrest and incomplete Autophagy, alters cytoskeleton structure and alleviates oxidative stress. Physalin B reduces cancer cell viability, ameliorates liver and lung tissue damage and alleviates liver fibrosis. Physalin B can be used in research related to ulcerative colitis, breast cancer, acute lung injury, colon cancer, non-alcoholic steatohepatitis, liver fibrosis, lung cancer, pancreatic cancer, lymphoma, ovarian cancer, sarcoma and leukemia .

HY-147646

CDK1/Cyc B-IN-1	CDK Apoptosis	Cancer
CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC₅₀ of 97 nM. CDK1/Cyc B-IN-1 triggers apoptosis and G2/M cell cycle arrest. CDK1/Cyc B-IN-1 shows broad-spectrum cytotoxic action against cancer cell lines .

HY-P991551

YS110	Dipeptidyl Peptidase p38 MAPK ERK	Infection Cancer
YS110 is a humanized anti-CD26 (DPP4) IgG1 monoclonal antibody. YS110 induces CD26 nuclear translocation through the caveolin pathway. YS110 inhibits the proliferation of tumor cell by delaying G2/M cell cycle transition. YS110 inhibits the infection of Middle East respiratory syndrome coronavirus (MERS CoV) by blocking the binding of MERS CoV S1 to CD26. YS110 can be used for researches on cancer or infection such as Malignant Mesothelioma and MERS .

HY-172609

SL-176	Phosphatase Apoptosis MDM-2/p53 Caspase	Metabolic Disease Cancer
SL-176 is a PPM1D (Wip1) inhibitor. SL-176 inhibits lipid droplet formation, downregulates the mRNA and protein expression of PPARγ and C/EBPα, and blocks adipocyte differentiation. SL-176 induces G2/M cell cycle arrest, apoptosis and inhibits cell proliferation in breast cancer cells overexpressing PPM1D, and activates components of the p53 pathway. SL-176 suppresses tumor growth in a zebrafish model of neuroblastoma. SL-176 is applicable to research related to obesity, breast cancer and neuroblastoma .

HY-W674241A

4-Ethylphenyl sulfate sodium	Endogenous Metabolite Apoptosis Bcl-2 Family Reactive Oxygen Species (ROS)	Neurological Disease Cancer
4-Ethylphenyl sulfate sodium is an orally active and brain-penetrant gut microbial metabolite. 4-Ethylphenyl sulfate sodium downregulates Bcl2 expression, upregulates Bax expression, and induces cancer cell apoptosis via the endogenous apoptotic pathway. 4-Ethylphenyl sulfate sodium induces G2/M cell cycle arrest and reactive oxygen species (ROS) production. 4-Ethylphenyl sulfate sodium impairs oligodendrocyte maturation, reduces oligodendrocyte-neuron interactions, decreases axonal myelination levels, and shifts the oligodendrocyte population toward immature precursor cells. 4-Ethylphenyl sulfate sodium alters brain region-specific neural activity and functional connectivity in mice, and correlates with anxiety-like behaviors in mice .

HY-103255

CFM-4	Apoptosis	Cancer
CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G₂M cell cycle arrest, and induces apoptosis with an IC₅₀ range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells .

HY-152226

MC2590	HDAC Apoptosis	Cancer
MC2590 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. MC2590 is a inhibitor of HDAC1-3, -6, -8, and -10 (class I/IIb-selective inhibitor) with IC₅₀s of 0.015 μM-0.156 μM. MC2590 also inhibits HDAC isoforms HDAC4, HDAC5, HDAC7, HDAC9, HDAC11 with IC₅₀s of 1.35 μM-3.98 μM. MC2625 induces G2/M cell cycle arrest and modulates pro- and anti-apoptotic microRNAs towards apoptosis induction .

HY-N1326

Santamarine Santamarin; Balchanin	JNK p38 MAPK MMP NF-κB COX TNF Receptor Interleukin Related Reactive Oxygen Species (ROS) Apoptosis Mitochondrial Metabolism DNA/RNA Synthesis Keap1-Nrf2 Bcl-2 Family Caspase PARP TGF-beta/Smad	Metabolic Disease Inflammation/Immunology Cancer
Santamarine (Santamarin; Balchanin) is a sesquiterpene lactone found in Artemisia scoparia. Santamarine shows anti-inflammatory, antioxidant, anticancer and anti-photoaging activities. Santamarine suppresses UVA-induced phosphorylation of JNK and p38 MAPK, nuclear translocation of phosphorylated c-Fos and c-Jun, and AP-1-mediated MMP-1 transcription and secretion. Santamarine suppresses NF-κB signaling, iNOS, COX-2, TNF-α, and IL-1β production. Santamarine inhibits thioredoxin reductase activity, induces ROS production, mitochondrial apoptosis, G2/M cell cycle arrest, and DNA damage, and reduces cancer cell growth. Santamarine can be used for the photoaging, inflammatory diseases and cancer .

HY-125135

(-)-β-Peltatin β-Peltatin	Apoptosis Bcl-2 Family Caspase PARP	Cancer
(-)-β-Peltatin is an aryltetrahydronaphthalene lignan. (-)-β-Peltatin exhibits antitumor activity and cytotoxicity against pancreatic cancer cells. (-)-β-Peltatin induces G2/M cell cycle arrest and apoptosis in pancreatic cancer cells. (-)-β-Peltatin inhibits the growth of subcutaneous xenografts of pancreatic cancer cells in nude mice. (-)-β-Peltatin can be used in pancreatic cancer-related research .

HY-179019

HDAC-IN-94	HDAC Microtubule/Tubulin Apoptosis Caspase	Neurological Disease Cancer
HDAC-IN-94 is a potent, selective HDAC6 inhibitor (IC₅₀ = 4.5 nM). HDAC-IN-94 shows >1000-fold selectivity over HDAC8 and shows minimal activity against other isoforms (HDAC1-3/10). HDAC-IN-94 induces α-tubulin hyperacetylation, apoptosis, and G2/M cell cycle arrest, exhibiting potent anti-tumor efficacy with low cytotoxicity. HDAC-IN-94 can be used for neuroblastoma and glioblastoma research .

HY-175555

Tubulin-IN-54	Microtubule/Tubulin Apoptosis	Cancer
Tubulin-IN-54 is a tubulin inhibitor. Tubulin-IN-54 exhibits anti-proliferative activity against various cancer cells. Tubulin-IN-54 inhibits tubulin polymerization, disrupts microtubule networks, induces G2/M cell cycle arrest, and promotes cancer cell apoptosis. Tubulin-IN-54 demonstrates significant anti-tumor efficacy in mice bearing PC-3/TxR xenografts. Tubulin-IN-54 can be used for the study of taxane-resistant cancers (prostate cancer, melanoma) .

HY-125257

SHP2 inhibitor LY6 LY6	Phosphatase SHP2 ERK Akt STAT JAK Apoptosis	Cancer
SHP2 inhibitor LY6 (LY6) is a selective SHP2 inhibitor with an IC₅₀ of 9.8 μM, showing 7-fold selectivity over SHP1. SHP2 inhibitor LY6 inhibits SHP2-mediated cell signaling pathways and suppresses cell proliferation. SHP2 inhibitor LY6 elicits induces apoptosis and G2/M cell cycle arrest in lung cancer cells. SHP2 inhibitor LY6 can be used for the research of B cell acute lymphoblastic leukemia, acute myeloid leukemia, and lung cancer .

HY-117087

K103	Phosphatase PANoptosis	Cancer
K103 is an inhibitor discovered from the screen that is an analog of the serotonin antagonist benzazocine. K103 exhibited inhibition of SHIP homologues, labelling it a pan-SHIP1/2 inhibitor, but the molecule had no effect on another 5' inositol phosphatase, OCRL. In line with the "two PIPs hypothesis", the molecule exhibited significant anti-tumour effects against a variety of cell lines, particularly breast cancer cells. Additional studies with K103 revealed that inhibition of SHIP1/2 in multiple myeloma cells resulted in G2/M cell cycle arrest followed by extensive apoptosis via activation of the caspase cascade. K103 fits the commonly used small molecule agent property profile, but while this work was being conducted, it was discovered that K103 caused psychoactive effects in mice, which limited the utility of the molecule in vivo. Therefore, certain synthetic studies were conducted on this tryptamine to identify the features that needed to be present in the molecule to maintain pan-SHIP1/2 inhibition in order to design an inhibitor with favourable pharmacodynamic properties and an improved side effect profile.

HY-N9534

Xylopine	Reactive Oxygen Species (ROS) Apoptosis	Cancer
Xylopine is an aporphine alkaloid with cytotoxic activity on cancer cells. Xylopine induces oxidative stress, causes G2/M cell cycle arrest and apoptosis in cancer cells .

HY-N11050

Xerophilusin B	Apoptosis	Cancer
Xerophilusin B, an anticancer agent isolated from Isodon xerophilus, exhibits antiproliferative effects on esophageal squamous cell carcinoma (ESCC) cell lines, induces G2/M cell cycle arrest, and mediates apoptosis .

HY-118748

Suprafenacine SRF	Microtubule/Tubulin	Cancer
Suprafenacine is a cell permeable, tubulin-destabilizing molecule which bind microtubules at the colchicine-binding site and inhibit polymerization. Suprafenacine can induce G2/M cell cycle arrest and apoptosis, and can be used for cancer research .

HY-P2698

1-Alaninechlamydocin	HDAC Apoptosis	Cancer
1-Alaninechlamydocin, a cyclic tetrapeptide, is a potent HDAC inhibitor (IC₅₀=6.4 nM). 1-Alaninechlamydocin induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells .

HY-143280

Topoisomerase II inhibitor 4	Topoisomerase	Cancer
Topoisomerase II inhibitor 4 (compound E17) is a potent Topoisomerase II inhibitor. Topoisomerase II inhibitor 4 triggers G2/M cell cycle arrest and shows anti-tumor activity with strong cytotoxic and anti-proliferative effect .

HY-116473

CFM-1	APC	Cancer
CFM-1 is a small molecule antagonist of CARP-1/APC-2 binding with an EC₅₀ value of 4.1 μM. CFM-1 induces G₂M cell cycle arrest and suppresses viabilities of human breast cancer cells .

HY-162695

Antitumor agent-168	Microtubule/Tubulin	Cancer
Antitumor agent-168 (compound 21b) disrupts the microtubule network in tumor cells leading to G2/M cell cycle arrest and apoptosis induction. Antitumor agent-168 inhibits MCF-7 growth with an IC₅₀ value of 1.4 nM .

HY-168128

Tubulin polymerization-IN-69	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-69 (compund 6c) significantly inhibits microtubule/tubulin polymerization in vitro (78.3% inhibition) with an IC₅₀ value of 6.53 μM, and rapidly induces apoptotic cell death and G2/M cell cycle arrest in MCF-7 cells .

HY-156182

JNK-IN-14	JNK Apoptosis	Cancer
JNK-IN-14 is a potent and selective JNK inhibitor with IC₅₀ values of 1.81, 12.7 and 10.5 nM for JNK1, JNK2 and JNK3, respectively. JNK-IN-14 induces early-stage apoptosis and G2/M cell cycle arrest. JNK-IN-14 can be used for cancer research

HY-161814

Apoptosis inducer 20	Apoptosis	Metabolic Disease
Apoptosis inducer 20 (12) causes G2/M cell cycle arrest and induction of apoptosis via caspase 3/7 activation, which occurred during M arrest. Apoptosis inducer 20 is a novel indolic benzenesulfonamide with anti-proliferative effect against a broad panel of cancer cell lines, which is proming for research of new anti-mitotic agents .

HY-155570

Anticancer agent 137	PI3K Apoptosis Caspase PARP	Cancer
Anticancer agent 137 (8q) is a potent PI3k inhibitor. Anticancer agent 137 has broad-spectrum anticancer activity. Anticancer agent 137 induces G2/M cell cycle arrest and apoptosis. Anticancer agent 137 increases cleaved PARP, caspase 3, and 7. Anticancer agent 137 can be used in research of cancer .

HY-172900

AKT-IN-27	Akt Apoptosis	Cancer
AKT-IN-27 (4a) is a potential anticancer agent through selective therapeutic targeting of Akt-driven pathways. AKT-IN-27 (4a) induces apoptosis via caspase-3 activation, G2/M cell cycle arrest, and mitochondrial membrane potential disruption. AKT-IN-27 (4a) can be used in the research for TNBC (triple-negative breast cancer) .

HY-168845

CDK2/9-IN-1	CDK Apoptosis	Cancer
CDK2/9-IN-1 (compound 20a) is an orally active dual inhibitor of CDK2 and CDK9 with IC₅₀ values are 0.004 μM and 0.009 μM respectively. CDK2/9-IN-1 induces apoptosis by regulating G2/M cell cycle arrest. CDK2/9-IN-1 has antitumor activity .

HY-158210

Wnt/β-catenin-IN-3	Wnt β-catenin MDM-2/p53	Cancer
Wnt/β-catenin-IN-3 (compound 17) is a Wnt/β-catenin inhibitor with low micromolarGI₅₀s against various cancer cells. Wnt/β-catenin-IN-3triggers G2/M cell cycle arrest though activation of p53-p21 pathway as well as intrinsic and extrinsic apoptotic death of colon cancer cells .

HY-162803

c-Met-IN-24	Apoptosis c-Met/HGFR STAT	Cancer
c-Met-IN-24 (compound 3g) is a dual-target inhibitor of STAT-3 ( =4.7 μM) and c-MET ( =12.67 μM) with anticancer activity. c-Met-IN-24 arrests the G2/M cell cycle and induces apoptosis in SNB-75 cells. c-Met-IN-24 can be used in the study of central nervous system cancers .

HY-158775

Ferroptocide	Ferroptosis Apoptosis Autophagy	Cancer
Ferroptocide is a cell death inducer that triggers ferroptosis and has anti-tumor activity. Ferroptocide can induce oxidative stress, leading to G2/M cell cycle arrest and apoptosis activation in LNCaP cells, while also effectively inhibiting the cell viability of both LNCaP and TRAMP-C1 cells. Ferroptocide can be used to study its capability to induce mitochondrial autophagy and to trigger immunogenic cell death (ICD) in prostate cancer cells .

HY-119948

AKCI	Cyclin G-associated Kinase (GAK) MDM-2/p53	Cancer
AKCI is a type of AURKC-IκBα interaction inhibitor, with an IC₅₀ value of 24.9 μM. In MDA-MB-231 cells, AKCI can induce G2/M cell cycle arrest by regulating the p53/p21/CDC2/cyclin B1 pathway, inhibit cell migration and invasion, and reduce colony formation and tumor growth. AKCI can be used for research on breast cancer .

Cat. No.	Product Name	Target	Research Area

HY-P11422

CKS9	Peptides	Infection
CKS9 is an M cell-targeting peptide. CKS9 exhibits high affinity towards M cells. CKS9 facilitates the transport of chitosan nanoparticles across the M cell to enter the follicle-associated epithelium (FAE) in Peyer’s patch (PP) of the gut. CKS9 can be used for swine dysentery research .

HY-P2698

1-Alaninechlamydocin	HDAC Apoptosis	Cancer
1-Alaninechlamydocin, a cyclic tetrapeptide, is a potent HDAC inhibitor (IC₅₀=6.4 nM). 1-Alaninechlamydocin induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991551

YS110	Dipeptidyl Peptidase p38 MAPK ERK	Infection Cancer
YS110 is a humanized anti-CD26 (DPP4) IgG1 monoclonal antibody. YS110 induces CD26 nuclear translocation through the caveolin pathway. YS110 inhibits the proliferation of tumor cell by delaying G2/M cell cycle transition. YS110 inhibits the infection of Middle East respiratory syndrome coronavirus (MERS CoV) by blocking the binding of MERS CoV S1 to CD26. YS110 can be used for researches on cancer or infection such as Malignant Mesothelioma and MERS .

Cat. No.	Product Name	Chemical Structure

HY-B0294S

Flubendazole-d3
Flubendazole-d₃ is the deuterium labeled Flubendazole. Flubendazole is a safe and efficacious anthelmintic agent, which is widely used for anthelmintic to human, rodents and ruminants. Flubendazole exerts anticancer activities by mechanisms including inhibition of microtubule function. Flubendazole induces p53-mediated apoptosis and arrests G2/M cell cycle .

HY-W013724S

Inosine-5'-diphosphate-15N4 dilithium

Inosine-5'-diphosphate- ¹⁵N₄ dilithium (IDP- ¹⁵N₄ dilithium) is ¹⁵N labeled Inosine-5'-diphosphate dilithium. Inosine-5'-diphosphate (IDP) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate has a superior bond capacity on GDP-binding pocket of NM23-H2 (K_D: 5.0 μM). Inosine-5'-diphosphate abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research .

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