JNK-IN-14
Based on 1 Customer Validation
JNK-IN-14 is a potent and selective JNK inhibitor with IC50 values of 1.81, 12.7 and 10.5 nM for JNK1, JNK2 and JNK3, respectively. JNK-IN-14 induces early-stage apoptosis and G2/M cell cycle arrest. JNK-IN-14 can be used for cancer research
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 2991432-56-3
- Formula: C27H31N5O4S
- Molecular Weight:521.63
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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JNK1 1.82 nM (IC50) |
JNK2 10.5 nM (IC50) |
JNK3 10.5 nM (IC50) |
CYP2D6 26.7 nM (IC50) |
CYP3A4 383.0 nM (IC50) |
JNK-IN-14 (compound 11e) (2.5 μM-5 μM, 24 h) leads to slight early-stage apoptosis in a concentration-dependent manner in K562 cells[1].
JNK-IN-14 (1.25-5 μM, 24 h) induces G2/M cell cycle arrest in K562 cells[1].
JNK-IN-14 exhibits a GI50 of 1.28 μM against NCI K562 cells[1].
JNK-IN-14 (2.5 μM-5 μM, 24 h) inhibits beclin-1 production in K562 leukemia cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:K562 Human Leukemia Cell
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Concentration:2.5 μM, 5 μM
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Incubation Time:24 h
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Result:Resulted in early-stage apoptosis with 1.94%, and 2.14% for 2.5 and 5 μM, respectively.
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Cell Line:K562 human leukemia cell
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Concentration:1.25 μM, 2.56 μM, 5 μM
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Incubation Time:24 h
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Result:Showed viable cells arrest at the G2/M phase with values of 45.33% at 1.25 μM, 2.5 μM at 62.99%, and 5 μM at 98.97%.
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Cell Line:K562 Cells
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Concentration:2.5 μM, 5 μM
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Incubation Time:24 h
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Result:Inhibited beclin-1 production at higher concentrations in K562 leukemia cells.
Chemical Information
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CAS No. 2991432-56-3
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Appearance Solid
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Molecular Weight 521.63
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Formula C27H31N5O4S
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Color White to off-white
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SMILES
CC(C)(N1C=C(C(C2=CC(O)=CC=C2)=N1)C3=CC=NC(NCCCNS(=O)(C4=CC=C(C=C4)O)=O)=C3)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (191.71 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9171 mL | 9.5853 mL | 19.1707 mL | 47.9267 mL |
| 5 mM | 0.3834 mL | 1.9171 mL | 3.8341 mL | 9.5853 mL | |
| 10 mM | 0.1917 mL | 0.9585 mL | 1.9171 mL | 4.7927 mL | |
| 15 mM | 0.1278 mL | 0.6390 mL | 1.2780 mL | 3.1951 mL | |
| 20 mM | 0.0959 mL | 0.4793 mL | 0.9585 mL | 2.3963 mL | |
| 25 mM | 0.0767 mL | 0.3834 mL | 0.7668 mL | 1.9171 mL | |
| 30 mM | 0.0639 mL | 0.3195 mL | 0.6390 mL | 1.5976 mL | |
| 40 mM | 0.0479 mL | 0.2396 mL | 0.4793 mL | 1.1982 mL | |
| 50 mM | 0.0383 mL | 0.1917 mL | 0.3834 mL | 0.9585 mL | |
| 60 mM | 0.0320 mL | 0.1598 mL | 0.3195 mL | 0.7988 mL | |
| 80 mM | 0.0240 mL | 0.1198 mL | 0.2396 mL | 0.5991 mL | |
| 100 mM | 0.0192 mL | 0.0959 mL | 0.1917 mL | 0.4793 mL |
JNK-IN-14 Related Classifications
HY-156182 Related Classifications
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