2. MAPK/ERK Pathway Metabolic Enzyme/Protease
  3. JNK Cytochrome P450
  4. JNK-IN-14

JNK-IN-14 is a potent JNK inhibitor with IC50 values of 1.81, 12.7 and 10.5 nM for JNK1, JNK2 and JNK3, respectively. JNK-IN-14 induces early-stage apoptosis. JNK-IN-14 shows cell population arrest at the G2/M phase and slightly inhibits beclin-1 production at K562 leukemia cells relative to SP600125 (HY-12041), showing higher inhibitory ability.

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JNK-IN-14 Chemical Structure

JNK-IN-14 Chemical Structure

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JNK-IN-14 Related Antibodies

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Description

JNK-IN-14 is a potent JNK inhibitor with IC50 values of 1.81, 12.7 and 10.5 nM for JNK1, JNK2 and JNK3, respectively. JNK-IN-14 induces early-stage apoptosis. JNK-IN-14 shows cell population arrest at the G2/M phase and slightly inhibits beclin-1 production at K562 leukemia cells relative to SP600125 (HY-12041), showing higher inhibitory ability.[1]

IC50 & Target

JNK1

1.82 nM (IC50)

JNK2

10.5 nM (IC50)

JNK3

10.5 nM (IC50)

CYP2D6

26.7 ± 0.5 nM (IC50)

CYP3A4

383.0 ± 1. nM (IC50)

In Vitro

JNK-IN-14 (compound 11e) (2.5 μM-5 μM, 24 h) leads to slight early-stage apoptosis in a concentration-dependent manner in K562 cells[1].
JNK-IN-14 (1.25-5 μM, 24 h) arrests cell population in K562 at higher concentrations in comparison with SP600125, showing higher inhibitory ability.[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNK-IN-14 Related Antibodies

Apoptosis Analysis

Cell Line: K562 Human Leukemia Cell
Concentration: 2.5 μM, 5 μM
Incubation Time: 24 h
Result: Resulted in early-stage apoptosis with 1.94%, and 2.14% for 2.5 and 5 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: K562 human leukemia cell
Concentration: 1.25 μM, 2.56 μM, 5 μM
Incubation Time: 24 h
Result: Showed viable cells arrest at the G2/M phase with values of 45.33% at 1.25 μM, 2.5 μM at 62.99%, and 5 μM at 98.97%.
Molecular Weight

521.63

Formula

C27H31N5O4S
SMILES

CC(C)(N1C=C(C(C2=CC(O)=CC=C2)=N1)C3=CC=NC(NCCCNS(=O)(C4=CC=C(C=C4)O)=O)=C3)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JNK-IN-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK-IN-14JNKCytochrome P450c-Jun N-terminal kinaseCYPsInhibitorinhibitorinhibit

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HY-156182
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