2. MAPK/ERK Pathway Apoptosis
  3. JNK Apoptosis
  4. JNK-IN-14

JNK-IN-14 is a potent and selective JNK inhibitor with IC50 values of 1.81, 12.7 and 10.5 nM for JNK1, JNK2 and JNK3, respectively. JNK-IN-14 induces early-stage apoptosis and G2/M cell cycle arrest. JNK-IN-14 can be used for cancer research

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JNK-IN-14

JNK-IN-14 Chemical Structure

CAS No. : 2991432-56-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO In-stock
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JNK-IN-14 Related Antibodies

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Description

JNK-IN-14 is a potent and selective JNK inhibitor with IC50 values of 1.81, 12.7 and 10.5 nM for JNK1, JNK2 and JNK3, respectively. JNK-IN-14 induces early-stage apoptosis and G2/M cell cycle arrest. JNK-IN-14 can be used for cancer research[1]

IC50 & Target

JNK1

1.82 nM (IC50)

JNK2

10.5 nM (IC50)

JNK3

10.5 nM (IC50)

CYP2D6

26.7 nM (IC50)

CYP3A4

383.0 nM (IC50)

In Vitro

JNK-IN-14 (compound 11e) (2.5 μM-5 μM, 24 h) leads to slight early-stage apoptosis in a concentration-dependent manner in K562 cells[1].
JNK-IN-14 (1.25-5 μM, 24 h) induces G2/M cell cycle arrest in K562 cells[1].
JNK-IN-14 exhibits a GI50 of 1.28 μM against NCI K562 cells[1].
JNK-IN-14 (2.5 μM-5 μM, 24 h) inhibits beclin-1 production in K562 leukemia cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNK-IN-14 Related Antibodies

Apoptosis Analysis[1]

Cell Line: K562 Human Leukemia Cell
Concentration: 2.5 μM, 5 μM
Incubation Time: 24 h
Result: Resulted in early-stage apoptosis with 1.94%, and 2.14% for 2.5 and 5 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: K562 human leukemia cell
Concentration: 1.25 μM, 2.56 μM, 5 μM
Incubation Time: 24 h
Result: Showed viable cells arrest at the G2/M phase with values of 45.33% at 1.25 μM, 2.5 μM at 62.99%, and 5 μM at 98.97%.

Western Blot Analysis[1]

Cell Line: K562 Cells
Concentration: 2.5 μM, 5 μM
Incubation Time: 24 h
Result: Inhibited beclin-1 production at higher concentrations in K562 leukemia cells.
Molecular Weight

521.63

Formula

C27H31N5O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)(N1C=C(C(C2=CC(O)=CC=C2)=N1)C3=CC=NC(NCCCNS(=O)(C4=CC=C(C=C4)O)=O)=C3)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (191.71 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9171 mL 9.5853 mL 19.1707 mL
5 mM 0.3834 mL 1.9171 mL 3.8341 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9171 mL 9.5853 mL 19.1707 mL 47.9267 mL
5 mM 0.3834 mL 1.9171 mL 3.8341 mL 9.5853 mL
10 mM 0.1917 mL 0.9585 mL 1.9171 mL 4.7927 mL
15 mM 0.1278 mL 0.6390 mL 1.2780 mL 3.1951 mL
20 mM 0.0959 mL 0.4793 mL 0.9585 mL 2.3963 mL
25 mM 0.0767 mL 0.3834 mL 0.7668 mL 1.9171 mL
30 mM 0.0639 mL 0.3195 mL 0.6390 mL 1.5976 mL
40 mM 0.0479 mL 0.2396 mL 0.4793 mL 1.1982 mL
50 mM 0.0383 mL 0.1917 mL 0.3834 mL 0.9585 mL
60 mM 0.0320 mL 0.1598 mL 0.3195 mL 0.7988 mL
80 mM 0.0240 mL 0.1198 mL 0.2396 mL 0.5991 mL
100 mM 0.0192 mL 0.0959 mL 0.1917 mL 0.4793 mL
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JNK-IN-14 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK-IN-142991432-56-3JNKApoptosisc-Jun N-terminal kinaseInhibitorinhibitorinhibit

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