2. MAPK/ERK Pathway Apoptosis
  3. JNK Apoptosis
  4. JNK-IN-14 TFA

JNK-IN-14 TFA is a potent and selective JNK inhibitor with IC50 values of 1.81, 12.7 and 10.5 nM for JNK1, JNK2 and JNK3, respectively. JNK-IN-14 TFA induces early-stage apoptosis and G2/M cell cycle arrest. JNK-IN-14 TFA can be used for cancer research

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JNK-IN-14 TFA

JNK-IN-14 TFA Chemical Structure

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JNK-IN-14 TFA Related Antibodies

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Description

JNK-IN-14 TFA is a potent and selective JNK inhibitor with IC50 values of 1.81, 12.7 and 10.5 nM for JNK1, JNK2 and JNK3, respectively. JNK-IN-14 TFA induces early-stage apoptosis and G2/M cell cycle arrest. JNK-IN-14 TFA can be used for cancer research[1]

In Vitro

JNK-IN-14 (compound 11e) (2.5 μM-5 μM, 24 h) TFA leads to slight early-stage apoptosis in a concentration-dependent manner in K562 cells[1].
JNK-IN-14 (1.25-5 μM, 24 h) TFA induces G2/M cell cycle arrest in K562 cells[1].
JNK-IN-14 TFA exhibits a GI50 of 1.28 μM against NCI K562 cells[1].
JNK-IN-14 (2.5 μM-5 μM, 24 h) TFA inhibits beclin-1 production in K562 leukemia cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNK-IN-14 TFA Related Antibodies

Cell Cycle Analysis[1]

Cell Line: K562 Human Leukemia Cell
Concentration: 1.25 μM, 2.5 μM, 5 μM
Incubation Time: 24 h
Result: Showed viable cells arrest at the G2/M phase with values of 45.33% at 1.25 μM, 2.5 μM at 62.99%, and 5 μM at 98.97%.

Apoptosis Analysis[1]

Cell Line: K562 Human Leukemia Cell
Concentration: 2.5 μM, 5 μM
Incubation Time: 24 h
Result: Resulted in early-stage apoptosis with 1.94%, and 2.14% for 2.5 and 5 μM, respectively.

Western Blot Analysis[1]

Cell Line: K562 Human Leukemia Cell
Concentration: 2.5 μM, 5 μM
Incubation Time: 24 h
Result: Inhibited beclin-1 production at higher concentrations in K562 leukemia cells.
Molecular Weight

635.65

Formula

C29H32F3N5O6S
Appearance

Solid

SMILES

O=C(O)C(F)(F)F.CC(C)(N1C=C(C(C2=CC(O)=CC=C2)=N1)C3=CC=NC(NCCCNS(=O)(C4=CC=C(C=C4)O)=O)=C3)C
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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JNK-IN-14 TFA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNK-IN-14JNKApoptosisc-Jun N-terminal kinaseInhibitorinhibitorinhibit

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