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Cat. No.: HY-156182A

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JNK-IN-14 TFA

JNK-IN-14 TFA is a potent and selective JNK inhibitor with IC₅₀ values of 1.81, 12.7 and 10.5 nM for JNK1, JNK2 and JNK3, respectively. JNK-IN-14 TFA induces early-stage apoptosis and G2/M cell cycle arrest. JNK-IN-14 TFA can be used for cancer research

For research use only. We do not sell to patients.

Formula: C₂₉H₃₂F₃N₅O₆S
Molecular Weight:635.65

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

JNK-IN-14 TFA Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

All JNK Isoforms :

In Vitro

JNK-IN-14 (compound 11e) (2.5 μM-5 μM, 24 h) TFA leads to slight early-stage apoptosis in a concentration-dependent manner in K562 cells^[1].
JNK-IN-14 (1.25-5 μM, 24 h) TFA induces G2/M cell cycle arrest in K562 cells^[1].
JNK-IN-14 TFA exhibits a GI₅₀ of 1.28 μM against NCI K562 cells^[1].
JNK-IN-14 (2.5 μM-5 μM, 24 h) TFA inhibits beclin-1 production in K562 leukemia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

K562 Human Leukemia Cell
Concentration:

1.25 μM, 2.5 μM, 5 μM
Incubation Time:

24 h
Result:

Showed viable cells arrest at the G2/M phase with values of 45.33% at 1.25 μM, 2.5 μM at 62.99%, and 5 μM at 98.97%.

Apoptosis Analysis^[1]

Cell Line:

K562 Human Leukemia Cell
Concentration:

2.5 μM, 5 μM
Incubation Time:

24 h
Result:

Resulted in early-stage apoptosis with 1.94%, and 2.14% for 2.5 and 5 μM, respectively.

Western Blot Analysis^[1]

Cell Line:

K562 Human Leukemia Cell
Concentration:

2.5 μM, 5 μM
Incubation Time:

24 h
Result:

Inhibited beclin-1 production at higher concentrations in K562 leukemia cells.

Chemical Information

Appearance Solid
Molecular Weight 635.65
Formula C₂₉H₃₂F₃N₅O₆S
SMILES

O=C(O)C(F)(F)F.CC(C)(N1C=C(C(C2=CC(O)=CC=C2)=N1)C3=CC=NC(NCCCNS(=O)(C4=CC=C(C=C4)O)=O)=C3)C
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Karim I Mersal, et al. Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.Eur J Med Chem. 2023 Sep 15:261:115779. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Purity & Documentation
References

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JNK-IN-14 TFA

All JNK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JNK-IN-14 TFA Related Classifications

HY-156182A Related Classifications