Inosine-5'-diphosphate disodium
Based on 1 Customer Validation
Inosine-5'-diphosphate disodium (IDP disodium) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate disodium has a superior bond capacity on GDP-binding pocket of NM23-H2 (KD: 5.0 μM). Inosine-5'-diphosphate disodium abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate disodium has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate disodium can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research.
For research use only. We do not sell to patients.
- Purity: 99.08%
- CAS No.: 54735-61-4
- Formula: C10H14N4O11P2
- Molecular Weight:428.19
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Inosine-5'-diphosphate disodium disrupts the interactions between NM23-H2 and c-MYC G-Quadruplex (Pu27-GQ). Inosine-5'-diphosphate disodium binds to the Guanosine diphosphate-binding pocket of NM23-H2 (Kd = 5.0 μM). Inosine-5'-diphosphate disodium synergizes c-MYC transcription-silencing effects of Pu27-GQ-binding ligands. Inosine-5'-diphosphate disodium has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate disodium can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research[1][2][3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 54735-61-4
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Appearance Solid
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Molecular Weight 428.19
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Formula C10H14N4O11P2
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Color White to off-white
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SMILES
O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O3)C=N2)NC=N1
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Synonyms
IDP disodium; Inosine-5'-diphosphoric acid disodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 175 mg/mL (408.70 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.3354 mL | 11.6771 mL | 23.3541 mL | 58.3853 mL |
| 5 mM | 0.4671 mL | 2.3354 mL | 4.6708 mL | 11.6771 mL | |
| 10 mM | 0.2335 mL | 1.1677 mL | 2.3354 mL | 5.8385 mL | |
| 15 mM | 0.1557 mL | 0.7785 mL | 1.5569 mL | 3.8924 mL | |
| 20 mM | 0.1168 mL | 0.5839 mL | 1.1677 mL | 2.9193 mL | |
| 25 mM | 0.0934 mL | 0.4671 mL | 0.9342 mL | 2.3354 mL | |
| 30 mM | 0.0778 mL | 0.3892 mL | 0.7785 mL | 1.9462 mL | |
| 40 mM | 0.0584 mL | 0.2919 mL | 0.5839 mL | 1.4596 mL | |
| 50 mM | 0.0467 mL | 0.2335 mL | 0.4671 mL | 1.1677 mL | |
| 60 mM | 0.0389 mL | 0.1946 mL | 0.3892 mL | 0.9731 mL | |
| 80 mM | 0.0292 mL | 0.1460 mL | 0.2919 mL | 0.7298 mL | |
| 100 mM | 0.0234 mL | 0.1168 mL | 0.2335 mL | 0.5839 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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