Disodium 5'-inosinate
Based on 1 publication(s) in Google Scholar
Disodium 5'-inosinate (IMP disodium salt) is a nucleotide-based umami agent. Disodium 5'-inosinate can bind to umami receptors and stimulate taste nerves, allowing the brain to perceive umami. In addition, Disodium 5'-inosinate produces a transient behavioral excitement in mice.
For research use only. We do not sell to patients.
- Purity: 99.74%
- CAS No.: 4691-65-0
- Formula: C10H11N4Na2O8P
- Molecular Weight:392.17
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Disodium 5'-inosinate
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Biological Activity
Disodium 5'-inosinate (500 mg/kg; Intravenous injection; Single dose) produces a transient behavioral excitement in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice[2]
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Dosage:500 mg/kg
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Administration:Intravenous injection (i.v.); Single dose
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Result:Produced a behavioral excitement, showing an increased movement, jumping and squeaking in response to tactile stimuli and enhanced preening and increased reflex response, but the animals became sedate after 60 min.
Chemical Information
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CAS No. 4691-65-0
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Appearance Solid
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Molecular Weight 392.17
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Formula C10H11N4Na2O8P
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Color White to off-white
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SMILES
O=P(OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C(N=CN=C32)O)O1)O)O)(O[Na])O[Na]
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Synonyms
IMP disodium salt; Disodium inosinate
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Structure Classification
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Initial Source
Corynebacterium stationis?KCCM 80235
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Microbiol Spectr
Potential quorum-sensing inhibitor of Hafnia alvei H4-theaflavin-3,3´-digallate analyzed by virtual screening and molecular simulation. [Abstract]2023 Sep 21;11(5):e0267123. PMID: 37732782
Solvent & Solubility
H2O : 250 mg/mL (637.48 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (127.50 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Adachi A, et al. Neuronal responses of the nucleus tractus solitarius to oral stimulation with umami substances. Physiol Behav. 1991 May;49(5):935-41. [Content Brief]
[2]. Kojima K. Safety evaluation of disodium 5'-inosinate, disodium 5'-guanylate and disodium 5'-ribonucleotide. Toxicology. 1974 Jun;2(2):185-206. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.5499 mL | 12.7496 mL | 25.4991 mL | 63.7479 mL |
| 5 mM | 0.5100 mL | 2.5499 mL | 5.0998 mL | 12.7496 mL | |
| 10 mM | 0.2550 mL | 1.2750 mL | 2.5499 mL | 6.3748 mL | |
| 15 mM | 0.1700 mL | 0.8500 mL | 1.6999 mL | 4.2499 mL | |
| 20 mM | 0.1275 mL | 0.6375 mL | 1.2750 mL | 3.1874 mL | |
| 25 mM | 0.1020 mL | 0.5100 mL | 1.0200 mL | 2.5499 mL | |
| 30 mM | 0.0850 mL | 0.4250 mL | 0.8500 mL | 2.1249 mL | |
| 40 mM | 0.0637 mL | 0.3187 mL | 0.6375 mL | 1.5937 mL | |
| 50 mM | 0.0510 mL | 0.2550 mL | 0.5100 mL | 1.2750 mL | |
| 60 mM | 0.0425 mL | 0.2125 mL | 0.4250 mL | 1.0625 mL | |
| 80 mM | 0.0319 mL | 0.1594 mL | 0.3187 mL | 0.7968 mL | |
| 100 mM | 0.0255 mL | 0.1275 mL | 0.2550 mL | 0.6375 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Disodium 5'-inosinate Related Classifications
HY-D0887 Related Classifications
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