Antitumor agent-168

Cat. No.: HY-162695: Data Sheet Handling Instructions
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Antitumor agent-168 (compound 21b) disrupts the microtubule network in tumor cells leading to G2/M cell cycle arrest and apoptosis induction. Antitumor agent-168 inhibits MCF-7 growth with an IC₅₀ value of 1.4 nM.

For research use only. We do not sell to patients.

Antitumor agent-168 Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.003 μM Compound: 21b	Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
A2780/Taxol	IC₅₀	4.8 nM Compound: 21b	Antiproliferative activity against paclitaxel resistant human A2780/Taxol cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against paclitaxel resistant human A2780/Taxol cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
A549	IC₅₀	0.001 μM Compound: 21b	Antiproliferative activity against human A549 assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human A549 assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
A549/TR	IC₅₀	1.6 nM Compound: 21b	Antiproliferative activity against paclitaxel resistant human A549/Taxol cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against paclitaxel resistant human A549/Taxol cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
DU-145	IC₅₀	0.004 μM Compound: 21b	Antiproliferative activity against human DU-145 assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human DU-145 assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
HCT-116	IC₅₀	0.003 μM Compound: 21b	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
HT-29	IC₅₀	0.011 μM Compound: 21b	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
HeLa	IC₅₀	0.9 nM Compound: 21b	Antiproliferative activity against human HeLa assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
MCF7	IC₅₀	0.001 μM Compound: 21b	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
MDA-MB-231	IC₅₀	0.02 μM Compound: 21b	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
MDA-MB-468	IC₅₀	0.01 μM Compound: 21b	Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
MGC-803	IC₅₀	0.5 nM Compound: 21b	Antiproliferative activity against human MGC-803 assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MGC-803 assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
PANC-1	IC₅₀	0.004 μM Compound: 21b	Antiproliferative activity against human PANC-1 assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human PANC-1 assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
SK-OV-3	IC₅₀	0.8 nM Compound: 21b	Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
U-87MG ATCC	IC₅₀	0.015 μM Compound: 21b	Antiproliferative activity against human U-87 MG assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human U-87 MG assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]

Molecular Weight

390.44

Formula

C₂₂H₂₂N₄O₃

SMILES

NC1=CC(C2=CC=C3C(N(C4=CC(OC)=C(OC)C(OC)=C4)C=N3)=N2)=CC=C1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fuhao Jiang, et al. Discovery of Novel Diaryl-Substituted Fused Heterocycles Targeting Katanin and Tubulin with Potent Antitumor and Antimultidrug Resistance Efficacy. J Med Chem. 2024 Jul 25;67(14) [Content Brief]