2. Cell Cycle/DNA Damage PI3K/Akt/mTOR Apoptosis
  3. Polo-like Kinase (PLK) Akt CDK Caspase Apoptosis
  4. NL13

NL13 is a Polo-like kinase 4 (PLK4) inhibitor with an IC50 value of 2.32 μM. NL13 can inhibit the viability of PC3 and DU145 prostate cancer cells, with IC50 values of 3.51 μM and 2.53 μM, respectively. NL13 can lead to the inactivation of the AKT signaling pathway by downregulating CCNB1/CDK1, inducing G2/M cell cycle arrest, and triggering apoptosis through the cleavage of caspase-9/caspase-3. In prostate cancer mice, NL13 can inhibit tumor growth.

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NL13

NL13 Estructura química

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NL13 Related Antibodies

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Ver todos los productos específicos de isoformas Polo-like Kinase (PLK):

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PLK1 PLK2 PLK3 PLK4

Ver todos los productos específicos de isoformas Akt:

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Akt Akt1 Akt2 Akt3

Ver todos los productos específicos de isoformas CDK:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Descripciòn

NL13 is a Polo-like kinase 4 (PLK4) inhibitor with an IC50 value of 2.32 μM. NL13 can inhibit the viability of PC3 and DU145 prostate cancer cells, with IC50 values of 3.51 μM and 2.53 μM, respectively. NL13 can lead to the inactivation of the AKT signaling pathway by downregulating CCNB1/CDK1, inducing G2/M cell cycle arrest, and triggering apoptosis through the cleavage of caspase-9/caspase-3. In prostate cancer mice, NL13 can inhibit tumor growth[1].
Peso molecular

400.30

Fòrmula

C22H19Cl2NO2
SMILES

ClC1=C(/C=C2CN(C(CC)=O)C/C(C\2=O)=C\C3=CC=CC=C3Cl)C=CC=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
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NL13 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NL13NL 13NL-13Polo-like Kinase (PLK)AktCDKCaspaseApoptosisPKBProtein kinase BCyclin dependent kinasePLK4PC3DU145CCNB1/CDK1prostate cancerInhibitorinhibitorinhibit

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NL13
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HY-162895
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