2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Autophagy
  3. HSP Autophagy
  4. BOLD-100 free base

BOLD-100 free base  (Synonyms: NKP-1339 free base; IT-139 free base; KP-1339 free base)

Cat. No.: HY-147039
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BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (BOLD-100) that retains the same biological activity.

For research use only. We do not sell to patients.

BOLD-100 free base Chemical Structure

BOLD-100 free base Chemical Structure

CAS No. : 783324-98-1

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BOLD-100 free base Related Antibodies

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Description

BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution[1].

IC50 & Target

GRP78[1]
Clinical Trial
Molecular Weight

479.15

Formula

C14H12Cl4N4Ru
CAS No.
SMILES

[Cl-][Ru+4]([Cl-])([Cl-])([N]1=CC2=CC=CC=C2N1)([N]3=CC4=CC=CC=C4N3)[Cl-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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BOLD-100 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BOLD-100783324-98-1NKP-1339IT-139KP-1339BOLD100BOLD 100NKP1339NKP 1339IT139IT 139KP1339KP 1339HSPAutophagyHeat shock proteinsapoptosisHep3BcoloncancermalignanttumorHepatomaMelanomaanticancercellular energy metabolismrutheniumHCT116glucose deprivationInhibitorinhibitorinhibit

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