AKT-IN-27
AKT-IN-27 (4a) is a potential anticancer agent through selective therapeutic targeting of Akt-driven pathways. AKT-IN-27 (4a) induces apoptosis via caspase-3 activation, G2/M cell cycle arrest, and mitochondrial membrane potential disruption. AKT-IN-27 (4a) can be used in the research for TNBC (triple-negative breast cancer).
For research use only. We do not sell to patients.
- Formula: C21H15NO4S
- Molecular Weight:377.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
AKT-IN-27 (4a) exhibits IC50 values of 3.29 μM, 4.81 μM, 3.99 μM and 7.25 μM in MDA-MB-231, A549, HeLa and HepG2 cells, respectively. AKT-IN-27 (4a) induces mitochondrial dysfunction in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 377.41
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Formula C21H15NO4S
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SMILES
O=C(C1=C(NC2=CC=CC=C2)SC(C3=O)=C1C(C4=C3C=CC=C4)=O)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AKT-IN-27 Related Classifications
HY-172900 Related Classifications
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