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Analgesic+activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Adrenergic Receptor (4) Aminopeptidase (2) Antibiotic (2) Apoptosis (12) Autophagy (2) Bacterial (3) Bcl-2 Family (2) Bradykinin Receptor (1) Calcium Channel (6) Cannabinoid Receptor (5) Carbonic Anhydrase (2) Caspase (1) Chemerin Receptor (1) Cholecystokinin Receptor (1) COX (26) CXCR (5) Drug Derivative (2) Drug Intermediate (5) Drug Metabolite (3) EGFR (1) Endogenous Metabolite (9) Epoxide Hydrolase (2) ERK (1) Eukaryotic Initiation Factor (eIF) (2) FAAH (3) Fungal (4) GABA Receptor (1) HDAC (1) Histamine Receptor (8) Histone Methyltransferase (1) Hydroxycarboxylic Acid Receptor (HCAR) (1) iGluR (1) Insecticide (1) Interleukin Related (3) Isotope-Labeled Compounds (3) JNK (1) Lipoxygenase (3) MAGL (1) mGluR (2) Mitophagy (2) Monoamine Transporter (1) nAChR (3) Neprilysin (1) Neurokinin Receptor (1) Neurotensin Receptor (1) NF-κB (2) NO Synthase (2) NOD-like Receptor (NLR) (1) Opioid Receptor (20) p38 MAPK (4) Phosphodiesterase (PDE) (1) PKC (3) Potassium Channel (5) PPAR (1) Prostaglandin Receptor (1) Reactive Oxygen Species (ROS) (5) Reference Standards (14) Sex Pheromone (1) Sigma Receptor (3) Sodium Channel (11) Taste Receptor (1) Thyroid Hormone Receptor (2) TNF Receptor (1) Trk Receptor (2) TRP Channel (10)
By Research Areas:	Cancer (21) Cardiovascular Disease (3) Infection (6) Inflammation/Immunology (87) Metabolic Disease (8) Neurological Disease (102)
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163

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10582

Flurbiprofen 4 Publications Verification dl-Flurbiprofen	COX Apoptosis	Infection Neurological Disease Inflammation/Immunology Cancer
Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer .

HY-10864

URB-597 5 Publications Verification KDS-4103	FAAH Autophagy Mitophagy	Neurological Disease
URB-597 (KDS-4103) is an orally bioavailable and selective FAAH inhibitor. URB-597 inhibits FAAH activity with an IC₅₀s of approximately 5 nM in rat brain membranes, 0.5 nM in intact rat neurons, 3 nM in human liver microsomes. Antidepressant-like effects. Analgesic activity .

HY-N0271

Echinocystic acid 3 Publications Verification	Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Echinocystic acid is a natural pentacyclic triterpene with potent antioxidant, anti-inflammatory and analgesic activities .

HY-14316A

Tebanicline dihydrochloride Ebanicline dihydrochloride; ABT-594 dihydrochloride	nAChR	Neurological Disease
Tebanicline dihydrochloride (Ebanicline dihydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a K_i of 37 pM .

HY-B1695

Methyl nicotinate Nicotinic acid methyl ester	Others	Cardiovascular Disease Inflammation/Immunology
Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .

HY-12511

SKF-86002 3 Publications Verification	p38 MAPK	Inflammation/Immunology
SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC₅₀ = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .

HY-114608

RY785	Sodium Channel	Neurological Disease
RY785 is a potent and selective voltage-gated potassium (K_V2) channel inhibitor with an IC₅₀ of 0.05 μM for K_V2.2. RY785 has analgesic activity .

HY-100326

PDE7-IN-3	Phosphodiesterase (PDE)	Neurological Disease Inflammation/Immunology
Pde7-in-3 (example 2) is an inhibitor of the phosphodiesterase PDE7 with potential analgesic activity. PDE7-IN-3 can be used to study inflammatory, neuropathic, visceral and nociceptive pain .

HY-N1847

3'-Methoxydaidzein	Sodium Channel	Neurological Disease
3'-Methoxydaidzein is a isoflavone and a Sodium Channel inhibitor. 3'-Methoxydaidzein inhibits subtypes NaV1.7, NaV1.8 and NaV1.3 with IC₅₀ of 181 nM, 397 nM, and 505 nM, respectively. 3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels .

HY-136363

MDR-652	TRP Channel	Neurological Disease
MDR-652 is a highly specific and efficacious transient receptor potential vanilloid 1 (TRPV1) ligand with agonist activity. The K_is are 11.4 and 23.8 nM for hTRPV1 and rTRPV1, respectively. The EC₅₀s are 5.05 and 93 nM for hTRPV1 and rTRPV1, respectively. Potent topical analgesic activity .

HY-129634

TrkA-IN-1	Trk Receptor	Neurological Disease
TrkA-IN-1 is a potent and selective Tropomyosin-related kinase A (TrkA) inhibitor with an IC₅₀ of 99 nM in a cell-based assay. TrkA-IN-1 has analgesic activity .

HY-114806

Fenclofenac Flenac; R 67408	Thyroid Hormone Receptor	Inflammation/Immunology
Fenclofenac is an orally active anti-inflammatory agent with a low ulcerogenic effect. Fenclofenac also exhibits antipyretic and analgesic activities, with an oral LD₅₀ of 2280 mg/kg in rats. Fenclofenac can be utilized in inflammation research .

HY-P11273

Urcosimod OK 101	Chemerin Receptor	Neurological Disease Inflammation/Immunology
Urcosimod (OK 101) is a lipid-coupled chemokine peptide, a ChemR23 G protein-coupled receptor agonist, which has been shown to have anti-inflammatory and analgesic activities. Urcosimod can be used for dry eye research .

HY-114771

α-Truxillic acid	Drug Intermediate	Inflammation/Immunology
α-Truxillic acid is form by the dimerization of two molecules of α-trans-cinnamic acid, with anti-inflammatory activities. α-Truxillic acid has no analgesic activity, but its derivatives bound to camphor fragments exhibit significant activity in the peripheral analgesic model (writhing test) .

HY-107345

Droxicam Ombolan	Prostaglandin Receptor	Inflammation/Immunology
Droxicam (Ombolan) is a non-steroidal anti-inflammatory agent, with strong analgesic activity. Droxicam acts by inhibiting PGE2 varies, and is characterised by being a pro-drug of Piroxicam (HY-B0253). Droxicam is well tolerated with slight side effects in the said mucosa. Droxicam does not show cardiovascular or respiratory effects in cats, and inhibits peritoneal capillary permeability in mouse .

HY-120033

RY796 2 Publications Verification	Sodium Channel	Neurological Disease
RY796 is a potent and selective voltage-gated potassium (K_V2) channel inhibitor with IC₅₀s of 0.25 μM and 0.09 μM for K_V2.1 and K_V2.2. RY796 has analgesic activity .

HY-W040705

2-(Methylamino)benzoic acid N-Methylanthranilic acid	Drug Metabolite	Others
2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver .

HY-10582S

Flurbiprofen-d3 dl-Flurbiprofen-d₃	COX Apoptosis	Inflammation/Immunology Cancer
Flurbiprofen-d₃ is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer .

HY-10582S1

Flurbiprofen-d5 dl-Flurbiprofen-d₅	COX Apoptosis	Inflammation/Immunology Cancer
Flurbiprofen-d₅ is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer .

HY-148656

PNB-001	Cholecystokinin Receptor	Inflammation/Immunology
PNB-001 is an orally active CCK2 selective ligand and antagonist. PNB-001 has anti-inflammatory and analgesic activities .

HY-N2573

Corydalmine L-Corydalmine; TLZ-16	Fungal CXCR	Infection Neurological Disease
Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi . Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity . Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway .

HY-103507

N-Arachidonyl-GABA	GABA Receptor	Neurological Disease
N-Arachidonoyl-GABA is one member of a new class of lipoamino acids related to anandamide identified in bovine brain. N-Arachidonoyl-GABA displays analgesic activity .

HY-101655

COX-2-IN-2	COX	Inflammation/Immunology
COX-2-IN-2 is a selective and inducible COX2 inhibitor with an IC₅₀ of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.

HY-403593

FCH-2296413	Hydroxycarboxylic Acid Receptor (HCAR)	Neurological Disease
FCH-2296413 is a potent and selective hydroxycarboxylic acid receptor (HCAR) agonist with an EC₅₀ of 4.4-8.6 nM. FCH-2296413 exhibits analgesic activity and can be used for the research of peripheral pain-related diseases .

HY-P991711

Povovetug	Trk Receptor	Neurological Disease Inflammation/Immunology
Povovetug is a humanized IgG1κ chimeric monoclonal antibody inhibitor targeting NGF/bNGF. Povovetug has a significant analgesic activity. Povovetug can be used for central neuroinflammation like chronic radicular pain research .

HY-W415953

Periplanetin	Sex Pheromone	Others
Periplanetin is a peptide of the insect lipomotor hormone family (AKH family) that can be isolated from the secretion of the cervical organ of Periplaneta americana L. and Blatta orientalis L. The periplanetin peptide has potential analgesic activity and lowers the threshold of tonic seizures .

HY-N2433

Paederosidic acid methyl ester	Potassium Channel	Neurological Disease
Paederosidic acid methyl ester is a ATP‐sensitive K ⁺ channel activator, isolated from P. scandens. Paederosidic acid methyl ester exhibits significant central analgesic activity, and enhances the threshold of pain by activating ATP‐sensitive K ⁺ channel in the brain and spinal cord level .

HY-W1121939

Perillyl acetate	Opioid Receptor	Neurological Disease Inflammation/Immunology
Perillyl acetate is a monoterpene found in in essential oils of plants and is synthesized from perillyl alcohol (HY-N7000). Perillyl acetate can activate the μ-opioid receptor and exert potent analgesic activity. Perillyl acetate can be used for the research of inflammation and neurological disease such as arthritis .

HY-139240

Cannabidihexol CBDH	Cannabinoid Receptor	Neurological Disease
Cannabidihexol is a phytocannabinoid with analgesic activity in mice .

HY-P4196

Met-Enkephalin-Arg-Phe	Opioid Receptor	Neurological Disease
Met-Enkephalin-Arg-Phe is a naturally occurring heptapeptide with analgesic activity .

HY-W748379

Fenyramidol (±)-Phenyramidol	Drug Derivative	Neurological Disease
Fenyramidol is an Aminopyridine derivative. Fenyramidol can be used as a moderately potent, non-narcotic muscle relaxant with concomitant analgesic activity .

HY-10869

OL-135	FAAH	Metabolic Disease
OL-135 is a CNS penetrant, selective, and reversible of FAAH inhibitor. OL-135 exhibits analgesic activity .

HY-170310

AP-238	Opioid Receptor	Neurological Disease
AP-238 is a a new synthetic opioid (NSO), and acts as an agonist for μ-opioid receptor (MOR) with an EC₅₀ of 248 nM. AP-238 exhibits analgesic activity .

HY-126609

Emorfazone Pentoil; Nandron	Bradykinin Receptor	Inflammation/Immunology
Emorfazone (Pentoil) is a non-steroidal anti-inflammatory drug with oral activity. Emorfazone can significantly inhibit the release of bradykinin-like substances and kininogen. Emorfazone has anti-inflammatory and analgesic activity .

HY-108480

SDZ NKT 343	Neurokinin Receptor	Neurological Disease
SDZ NKT 343 is a selective, orally active NK₁ receptor antagonist with an IC₅₀ of 0.62 nM against human NK₁ receptor. SDZ NKT 343 has good analgesic activity .

HY-121854A

Bromadoline maleate	Opioid Receptor	Inflammation/Immunology
Bromadoline maleate is an opioid analgesic selective for the μ-opioid receptor, exhibiting analgesic activity in various biological fluids. Bromadoline maleate has been successfully quantified alongside its N-demethylated metabolites in human and canine samples.

HY-W023253

Biclotymol	Bacterial Fungal	Infection Inflammation/Immunology
Biclotymol is an antimicrobial agent against gram-positive cocci. Biclotymol inhibits Streptococcus pneumoniae and Haemophilus influenzae, with MIC of 150 and 150 μM. Biclotymol exhibits anti-inflammatory and analgesic activity and ameliorates the otolaryngology infection and throat sore .

HY-P5907

Helianorphin-19	Opioid Receptor	Neurological Disease
Helianorphin-19 is a potent and selective κ-opioid receptor (KOR) activator with a K_i of 21 nM and an EC₅₀ of 45 nM. Helianorphin-19 exhibits strong KOR-specific peripheral analgesic activity in a mouse model of chronic visceral pain .

HY-N11960

Ignavine	Opioid Receptor	Inflammation/Immunology
Ignavine is a conformational modulator of μ-opioid receptors (IC₅₀ = 2.0 μM). Ignavine exhibits a concentration dependent bidirectional regulatory effect in vitro. Ignavine has analgesic activity. Ignavine can be used for research on pain related conditions .

HY-P5159

Crotamine	Sodium Channel	Inflammation/Immunology
Crotamine is a Na ⁺ channel modulator. Crotamine is a 42 amino acid toxin cross-linked by three disulfide bridges. Crotamine has analgesic activity. Crotamine also interacts with lipid membranes and shows myonecrotic activity. Crotamine can be isolated from Crotalus durissus terrificus venom .

HY-P5159A

Crotamine TFA	Sodium Channel	Inflammation/Immunology
Crotamine TFA is a Na ⁺ channel modulator. Crotamine is a 42 amino acid toxin cross-linked by three disulfide bridges. Crotamine has analgesic activity. Crotamine also interacts with lipid membranes and shows myonecrotic activity. Crotamine can be isolated from Crotalus durissus terrificus venom .

HY-137525

NTRC-808	Neurotensin Receptor	Neurological Disease
NTRC-808 is a nonpeptide selective GPCR neurotensin receptor type 2 (NTS2) partial agonist with an EC₅₀ of 14 nM and K_i of 88 nM. NTRC-808 has higher selectivity for NTS2 than for NTS1. NTRC-808 has antipsychotic and analgesic activity .

HY-P2046

β-Endorphin (rat)	Opioid Receptor	Neurological Disease
β-Endorphin (rat) is an endogenous opioid neuropeptide and peptide hormone. β-Endorphin (rat) has analgesic activity and also contributes to food intake in satiated rats. β-Endorphin (rat) can be used in the research of neurological diseases such as analgesia and drug addiction .

HY-173030

Opioid receptor agonist 1	Opioid Receptor	Neurological Disease
Opioid receptor agonist 1 (Compound 2638-28) is the orally active agonist for opioid receptor that exhibits good affinity to MOR, DOR and KOR with K_i of 5, 24 and 212 nM, respectively. Opioid receptor agonist 1 exhibits analgesic activity in mouse warm water tail flick models and acetic acid writhing models .

HY-173083

MDA7	Cannabinoid Receptor	Neurological Disease
MDA7 is the selective agonist for cannabinoid receptor 2 with EC₅₀ of 128 nM and 67.4 nM in human CB2 receptor and rat CB2 receptor. MDA7 exhibits good affinity to human CB2 receptor and rat CB2 receptor with K_i of 422 nM and 238 nM. MDA7 exhibits analgesic activity in rats models .

HY-W725190

Piperidylthiambutene hydrochloride	Opioid Receptor	Neurological Disease
Piperidylthiambutene hydrochloride is an opioid with analgesic activity in animal models.

HY-162570

Volazocine	Opioid Receptor	Others
Volazocine is an opioid benzomorphane derivative with potential analgesic activity .

HY-W683876

Desmethylmoramide	Opioid Receptor	Neurological Disease
Desmethylmoramide is structurally similar to known opioids. Desmethylmoramide has analgesic activity in rodents .

HY-129237

Azo-enkephalin	Opioid Receptor	Neurological Disease
Azo-enkephalin is an endorphin analog with significant analgesic activity. Azo-enkephalin can be used in the development of opioid analgesics .

HY-10635A

(S)-ABT-102	TRP Channel	Inflammation/Immunology Cancer
(S)-ABT-102 is a TRPV1 Antagonist, with an IC₅₀ of 123 nM. (S)-ABT-102 has analgesic activity .

Cat. No.	Product Name	Target	Research Area

HY-W345510

Opiorphin	Neprilysin	Neurological Disease
Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC₅₀ value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission .

HY-P11273

Urcosimod OK 101	Chemerin Receptor	Neurological Disease Inflammation/Immunology
Urcosimod (OK 101) is a lipid-coupled chemokine peptide, a ChemR23 G protein-coupled receptor agonist, which has been shown to have anti-inflammatory and analgesic activities. Urcosimod can be used for dry eye research .

HY-W040705

2-(Methylamino)benzoic acid N-Methylanthranilic acid	Drug Metabolite	Others
2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver .

HY-P3869

Lumekefamide [D-Arg2]Dermorphin-(1-4) amide	Peptides	Neurological Disease
Lumekefamide ([D-Arg2]Dermorphin-(1-4) amide) is a N-terminal shorter peptide amide of [D-Arg2]dermorphin with the hypothermic effect. Lumekefamide shows analgesic activity and degradation in soluble mouse liver and brain extracts .

HY-P4196

Met-Enkephalin-Arg-Phe	Opioid Receptor	Neurological Disease
Met-Enkephalin-Arg-Phe is a naturally occurring heptapeptide with analgesic activity .

HY-P5907

Helianorphin-19	Opioid Receptor	Neurological Disease
Helianorphin-19 is a potent and selective κ-opioid receptor (KOR) activator with a K_i of 21 nM and an EC₅₀ of 45 nM. Helianorphin-19 exhibits strong KOR-specific peripheral analgesic activity in a mouse model of chronic visceral pain .

HY-P5159

Crotamine	Sodium Channel	Inflammation/Immunology
Crotamine is a Na ⁺ channel modulator. Crotamine is a 42 amino acid toxin cross-linked by three disulfide bridges. Crotamine has analgesic activity. Crotamine also interacts with lipid membranes and shows myonecrotic activity. Crotamine can be isolated from Crotalus durissus terrificus venom .

HY-P5159A

Crotamine TFA	Sodium Channel	Inflammation/Immunology
Crotamine TFA is a Na ⁺ channel modulator. Crotamine is a 42 amino acid toxin cross-linked by three disulfide bridges. Crotamine has analgesic activity. Crotamine also interacts with lipid membranes and shows myonecrotic activity. Crotamine can be isolated from Crotalus durissus terrificus venom .

HY-P2046

β-Endorphin (rat)	Opioid Receptor	Neurological Disease
β-Endorphin (rat) is an endogenous opioid neuropeptide and peptide hormone. β-Endorphin (rat) has analgesic activity and also contributes to food intake in satiated rats. β-Endorphin (rat) can be used in the research of neurological diseases such as analgesia and drug addiction .

HY-P3869A

Lumekefamide TFA [D-Arg2]Dermorphin-(1-4) amide TFA	Peptides	Neurological Disease
Lumekefamide TFA ([D-Arg2]Dermorphin-(1-4) amide TFA) is a N-terminal shorter peptide amide of [D-Arg2]dermorphin with the hypothermic effect. Lumekefamide shows analgesic activity and degradation in soluble mouse liver and brain extracts .

HY-W040705R

2-(Methylamino)benzoic acid (Standard) N-Methylanthranilic acid (Standard)	Drug Metabolite Reference Standards	Others
2-(Methylamino)benzoic acid (Standard) is the analytical standard of 2-(Methylamino)benzoic acid. This product is intended for research and analytical applications. 2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver[1].

Cat. No.	Product Name	Target	Research Area	Image

HY-P991711

Povovetug	Trk Receptor	Neurological Disease Inflammation/Immunology
Povovetug is a humanized IgG1κ chimeric monoclonal antibody inhibitor targeting NGF/bNGF. Povovetug has a significant analgesic activity. Povovetug can be used for central neuroinflammation like chronic radicular pain research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18981

Decursin 2 Publications Verification (+)-Decursin	Classification of Application Fields Coumarins Phenylpropanoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Echinacea angustifolia DC. Source Classification	PKC Apoptosis CXCR
Decursin ((+)-Decursin) is a potent anti-tumor agent. Decursin also is a cytotoxic agent and a potent protein kinase C activator. Decursin induces apoptosis and cell cycle arrest at G1 phase. Decursin decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h. Decursin inhibits cell proliferation and migration. Decursin shows anti-tumor, anti-inflammatory and analgesic activities .

HY-N3017

Artemitin 1 Publications Verification	Flavonols Monophenols Flavonoids other families Classification of Application Fields Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Antibiotic
Artemitin is a flavonoid neuroanesthetic agent with moderate cytotoxicity. Artemitint has selective inhibitory activity against Meth-A sarcoma cells with an ED₅₀ of 5-10 μg/mL, and has no significant effect on LLC lung cancer cells. Artemitin exerts anticancer activity by affecting cell proliferation signaling pathways, and also has potential anti-inflammatory and neuroprotective effects. Artemitin exhibits a dose-dependent antinociceptive effect in the mouse hot plate test, with an ED₅₀ of 1.6 μg/kg, and has analgesic activity .

HY-N0271

Echinocystic acid 3 Publications Verification	Triterpenes Classification of Application Fields Leguminosae Terpenoids Gleditsia sinensis Lam. Plants Disease Research Fields Cancer	Reactive Oxygen Species (ROS) Apoptosis
Echinocystic acid is a natural pentacyclic triterpene with potent antioxidant, anti-inflammatory and analgesic activities .

HY-N1440

Koumine	Alkaloids Classification of Application Fields Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Inflammation/Immunology Disease Research Fields Indole Alkaloids Source Classification	Bcl-2 Family
Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

HY-111664

(R)-(+)-Citronellal (+)-Citronellal	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Citrus limon (L.) Burm. F. Rutaceae Metabolic Disease Plants Endogenous metabolite Disease Research Fields Citrus reticulata Blanco Source Classification	Bacterial Fungal Insecticide Taste Receptor Opioid Receptor
(R)-(+)-Citronellal ((+)-Citronellal) is a monoterpenoid compound and is one of the main components of essential oils from plants such as lemon grass. (R)-(+)-Citronellal has antibacterial, antifungal, and insecticidal activities. (R)-(+)-Citronellal alleviates the bitterness of caffeine by antagonizing the bitter taste receptors Tas2r43 (IC₅₀ = 84 μM) and Tas2R46. (R)-(+)-Citronellal generates analgesic activity by activating the opioid receptor (broad-spectrum opioid receptor) pathway, and its effect is particularly significant for inflammatory pain .

HY-N5084

Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside	Structural Classification Flavonoids Classification of Application Fields Flavonones Other Diseases Phenols Polyphenols Saxifragaceae Plants Penthorum chinense Pursh Disease Research Fields Source Classification	TRP Channel HDAC p38 MAPK JNK ERK NF-κB TNF Receptor Interleukin Related
Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside is a TRPV1 antagonist and HDAC7 inhibitor. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside blocks TRPV1-mediated calcium influx, suppresses phosphorylation of p65, IκBα, p38, JNK, and ERK1/2, inhibiting NF-κB and MAPK signaling cascades. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside reduces production and gene expression of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside exhibits potent analgesic activity, elevates thermal pain threshold and mechanical pain threshold in murine models. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside restores CD8 ⁺ T cell infiltration into bladder cancer tumors and improves bladder cancer immunotherapy efficacy. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside can be used for the researches of painand bladder cancer .

HY-B1695

Methyl nicotinate Nicotinic acid methyl ester	Natural Products Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	Others
Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .

HY-N1847

3'-Methoxydaidzein	Flavonoids Leguminosae Maackia amurensis Rupr. et Maxim. Plants Isoflavones Source Classification	Sodium Channel
3'-Methoxydaidzein is a isoflavone and a Sodium Channel inhibitor. 3'-Methoxydaidzein inhibits subtypes NaV1.7, NaV1.8 and NaV1.3 with IC₅₀ of 181 nM, 397 nM, and 505 nM, respectively. 3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels .

HY-17428

Tripelennamine hydrochloride	Structural Classification Alkaloids Classification of Application Fields Pyridine Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Histamine Receptor
Tripelennamine hydrochloride is a histamine H1-receptor antagonist. Tripelennamine hydrochloride effectively reverses histamine-induced bronchoconstriction, increased transpulmonary pressure, elevated pulmonary vascular resistance and reduced dynamic compliance. Tripelennamine hydrochloride does not significantly affect arterial hypoxemia, hemoglobin desaturation and hypercapnia in horses undergoing short-term high-intensity exercise. Tripelennamine hydrochloride exhibits local and central analgesic activity. Tripelennamine hydrochloride can be used in studies related to emphysema, urticaria and acute laminitis .

HY-W007539

2,4-Dihydroxybenzaldehyde	Monophenols Ketones, Aldehydes, Acids Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Intermediate NO Synthase Reactive Oxygen Species (ROS) COX
2,4-Dihydroxybenzaldehyde is an endogenous metabolite. 2,4-Dihydroxybenzaldehyde is a pharmaceutical intermediate that can be used to synthesize various Schiff base compounds. 2,4-Dihydroxybenzaldehyde exhibits significant anti angiogenic, anti-inflammatory, and analgesic activities. 2,4-Dihydroxybenzaldehyde reduces the production of NO and ROS by inhibiting the expression of iNOS and COX-2. 2,4-Dihydroxybenzaldehyde is commonly used in the study of inflammatory conditions .

HY-W040705

2-(Methylamino)benzoic acid N-Methylanthranilic acid	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Drug Metabolite
2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver .

HY-N2573

Corydalmine L-Corydalmine; TLZ-16	Alkaloids Monophenols Corydalis yanhusuo W. T. Wang Phenols Plants Isoquinoline Alkaloids Papaveraceae Source Classification	Fungal CXCR
Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi . Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity . Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway .

HY-B1695R

Methyl nicotinate (Standard) Nicotinic acid methyl ester (Standard)	Structural Classification Natural Products Microorganisms Source Classification	Reference Standards Others
Methyl nicotinate (Standard) is the analytical standard of Methyl nicotinate. This product is intended for research and analytical applications. Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .

HY-W747297

β-Selinene	Other Terpenoids Structural Classification Terpenoids Psidium guajava Linn. Myrtaceae Plants Source Classification	COX Endogenous Metabolite
β-Selinene is a sesquiterpene and is the main active component of the essential oil of red purple hibiscus (Callicarpa macrophylla). β-Selinene exhibits significant related antioxidant activity, anti-inflammatory activity, and antipyretic analgesic activity. β-Selinene may exert antioxidant effects by directly scavenging free radicals (DPPH, NO, •OH) and chelating pro-oxidative metal ions (Fe²⁺); inhibit cyclooxygenase (COX) activity, reduce prostaglandin (such as PGE₂) synthesis to exert anti-inflammatory effects; regulate the thermoregulatory set point of the hypothalamus and inhibit inflammatory mediators to exert antipyretic and analgesic effects .

HY-W415953

Periplanetin	Animals Saccharides Monosaccharides Source Classification	Sex Pheromone
Periplanetin is a peptide of the insect lipomotor hormone family (AKH family) that can be isolated from the secretion of the cervical organ of Periplaneta americana L. and Blatta orientalis L. The periplanetin peptide has potential analgesic activity and lowers the threshold of tonic seizures .

HY-N2433

Paederosidic acid methyl ester	Iridoids Terpenoids Paederia scandens (Lour.) Merr. Rubiaceae Plants Source Classification	Potassium Channel
Paederosidic acid methyl ester is a ATP‐sensitive K ⁺ channel activator, isolated from P. scandens. Paederosidic acid methyl ester exhibits significant central analgesic activity, and enhances the threshold of pain by activating ATP‐sensitive K ⁺ channel in the brain and spinal cord level .

HY-W1121939

Perillyl acetate	Citrus × aurantium Natsudaidai Rutaceae Plants Source Classification	Opioid Receptor
Perillyl acetate is a monoterpene found in in essential oils of plants and is synthesized from perillyl alcohol (HY-N7000). Perillyl acetate can activate the μ-opioid receptor and exert potent analgesic activity. Perillyl acetate can be used for the research of inflammation and neurological disease such as arthritis .

HY-P4196

Met-Enkephalin-Arg-Phe	Monophenols Phenols Endogenous metabolite Source Classification	Opioid Receptor
Met-Enkephalin-Arg-Phe is a naturally occurring heptapeptide with analgesic activity .

HY-N11960

Ignavine	Structural Classification Alkaloids Aconitum tasiromontanum Nakai Other Alkaloids Ranunculaceae Plants Source Classification	Opioid Receptor
Ignavine is a conformational modulator of μ-opioid receptors (IC₅₀ = 2.0 μM). Ignavine exhibits a concentration dependent bidirectional regulatory effect in vitro. Ignavine has analgesic activity. Ignavine can be used for research on pain related conditions .

HY-N12398

Psychotridine	Alkaloids Psychotria forsteriana A.Gray Rubiaceae Plants Indole Alkaloids Source Classification	Others
Psychotridine is a natural alkaloid isolated from Psychotria colorata, reveals an analgesic activity in nervous system and an inhibitory efficacy towards platelet aggregation .

HY-N0271R

Echinocystic acid (Standard)	Triterpenes Structural Classification Leguminosae Terpenoids Gleditsia sinensis Lam. Plants	Reference Standards Reactive Oxygen Species (ROS) Apoptosis
Echinocystic acid (Standard) is the analytical standard of Echinocystic acid. This product is intended for research and analytical applications. Echinocystic acid is a natural pentacyclic triterpene with potent antioxidant, anti-inflammatory and analgesic activities .

HY-N10171

GB-2a	Flavonoids Rubiaceae Plants Gardenia jasminoides Ellis Other Flavonoids Source Classification	Others
GB-2a is a bioflavonoids that can be isolated from Rheedia gardneriana. GB-2a has significant analgesic activity in mice with 58.9% inhibition .

HY-N12067

Columbianetin β-D-glucopyranoside	Plants Umbelliferae Seriphidium transiliense Saccharides Monosaccharides Source Classification	Others
Columbianetin β-D-glucopyranoside can be isolated from Angelicae pubescentis radix and has antiplatelet aggregation, anti-inflammatory and analgesic activities. Columbianetin β-D-glucopyranoside exerts significant protective effects against glutamate-induced toxicity .

HY-N9854

Icariside E4	Tabebuia roseoalba (Ridl.) Sandwith Natural Products Plants Bignoniaceae Source Classification	Potassium Channel
Icariside E4 is an antinociceptive agent, and can be isolated from Tabebuia roseo-alba. Icariside E4 has peripheral analgesic activity by ATP-sensitive K ⁺ channel-dependent mechanisms. Icariside E4 also has anti-oxidant, anti-Alzheimer and anti-inflammatory effects .

HY-N1440R

Koumine (Standard)	Alkaloids Structural Classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Indole Alkaloids Source Classification	Reference Standards Bcl-2 Family
Koumine (Standard) is the analytical standard of Koumine. This product is intended for research and analytical applications. Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

HY-17428A

Tripelennamine	Structural Classification Alkaloids Classification of Application Fields Pyridine Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Source Classification	Histamine Receptor
Tripelennamine is a histamine H1-receptor antagonist. Tripelennamine effectively reverses histamine-induced bronchoconstriction, increased transpulmonary pressure, elevated pulmonary vascular resistance and reduced dynamic compliance. Tripelennamine does not significantly affect arterial hypoxemia, hemoglobin desaturation and hypercapnia in horses undergoing short-term high-intensity exercise. Tripelennamine exhibits local and central analgesic activity. Tripelennamine can be used in studies related to emphysema, urticaria and acute laminitis .

HY-17428B

Tripelennamine citrate	Structural Classification Alkaloids Classification of Application Fields Pyridine Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Source Classification	Histamine Receptor
Tripelennamine citrate is a histamine H1-receptor antagonist. Tripelennamine citrate effectively reverses histamine-induced bronchoconstriction, increased transpulmonary pressure, elevated pulmonary vascular resistance and reduced dynamic compliance. Tripelennamine citrate does not significantly affect arterial hypoxemia, hemoglobin desaturation and hypercapnia in horses undergoing short-term high-intensity exercise. Tripelennamine citrate exhibits local and central analgesic activity. Tripelennamine citrate can be used in studies related to emphysema, urticaria and acute laminitis .

HY-18981R

Decursin (Standard) (+)-Decursin (Standard)	Structural Classification Coumarins Phenylpropanoids Umbelliferae Plants Echinacea angustifolia DC. Source Classification	Reference Standards PKC Apoptosis CXCR
Decursin (Standard) is the analytical standard of Decursin. This product is intended for research and analytical applications. Decursin ((+)-Decursin) is a potent anti-tumor agent. Decursin also is a cytotoxic agent and a potent protein kinase C activator. Decursin induces apoptosis and cell cycle arrest at G1 phase. Decursin decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h. Decursin inhibits cell proliferation and migration. Decursin shows anti-tumor, anti-inflammatory and analgesic activities [4].

HY-W007539R

2,4-Dihydroxybenzaldehyde (Standard)	Monophenols Ketones, Aldehydes, Acids Phenols Polyphenols Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Drug Intermediate NO Synthase Reactive Oxygen Species (ROS) COX
2,4-Dihydroxybenzaldehyde (Standard) is the analytical standard of 2,4-Dihydroxybenzaldehyde. This product is intended for research and analytical applications. 2,4-Dihydroxybenzaldehyde is an endogenous metabolite. 2,4-Dihydroxybenzaldehyde is a pharmaceutical intermediate that can be used to synthesize various Schiff base compounds. 2,4-Dihydroxybenzaldehyde exhibits significant anti angiogenic, anti-inflammatory, and analgesic activities. 2,4-Dihydroxybenzaldehyde reduces the production of NO and ROS by inhibiting the expression of iNOS and COX-2. 2,4-Dihydroxybenzaldehyde is commonly used in the study of inflammatory conditions .

HY-17428R

Tripelennamine hydrochloride (Standard)	Structural Classification Alkaloids Pyridine Alkaloids Endogenous metabolite Source Classification	Reference Standards Histamine Receptor
Tripelennamine hydrochloride (Standard) is the analytical standard of Tripelennamine hydrochloride (HY-17428). This product is intended for research and analytical applications. Tripelennamine hydrochloride is a histamine H1-receptor antagonist. Tripelennamine hydrochloride effectively reverses histamine-induced bronchoconstriction, increased transpulmonary pressure, elevated pulmonary vascular resistance and reduced dynamic compliance. Tripelennamine hydrochloride does not significantly affect arterial hypoxemia, hemoglobin desaturation and hypercapnia in horses undergoing short-term high-intensity exercise. Tripelennamine hydrochloride exhibits local and central analgesic activity. Tripelennamine hydrochloride can be used in studies related to emphysema, urticaria and acute laminitis .

HY-N18059

Spiradine A 6-Hydroxyhetisan-11-one	Structural Classification Alkaloids Thalictrum javanicum Blume Pyrrole Alkaloids Ranunculaceae Plants Source Classification	Others
Spiradine A (6-Hydroxyhetisan-11-one) is a C₂₀ diterpenoid alkaloid present in the roots of Thalictrum sessile (Ranunculaceae), and is originally isolated from Spiraea japonica (Rosaceae). Spiradine A may possess anti-inflammatory and analgesic activities .

HY-N19281

Puberulin	Structural Classification Agathosma puberula (Steud.) Fourc. Rutaceae Coumarins Phenylpropanoids Plants Source Classification	Drug Derivative
Puberulin is a coumarin compound and an orally effective analgesic. Puberulin is present in Choisya ternata var. Sundance. Puberulin exerts analgesic activity against chemical and heat-induced pain agents in mouse models, and this activity does not involve opioid receptors or muscarinic receptors. Puberulin can be used in the research of neuropathic pain .

HY-119925

Amaralin	Structural Classification Prosopis juliflora (Sw.) DC. Terpenoids Sesquiterpenes Plants Compositae Source Classification	Drug Intermediate
Amaralin is a sesquiterpene lactone with analgesic activity, which exists in the leaves and stems of Helenium amarum (Raf.) H. Rock. When administered subcutaneously, Amaralin produces analgesic effects in the mouse tail-flick test. When administered subcutaneously, Amaralin inhibits acetic acid-induced writhing syndrome in mice. Amaralin can be used for pain-related research .

HY-W040705R

2-(Methylamino)benzoic acid (Standard) N-Methylanthranilic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Drug Metabolite Reference Standards
2-(Methylamino)benzoic acid (Standard) is the analytical standard of 2-(Methylamino)benzoic acid. This product is intended for research and analytical applications. 2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver[1].

HY-N19667

8-[2-(3-Methylbutroxy)-3-hydroxy-3-methylbutoxy]psoralen	Structural Classification Angelica archangelica L. Coumarins Phenylpropanoids Umbelliferae Plants Source Classification	Calcium Channel
8-[2-(3-Methylbutroxy)-3-hydroxy-3-methylbutoxy]psoralen (Compound 12), a furanocoumarin found in the roots of A. archangelica L. archangelica, is an calcium antagonist. 8-[2-(3-Methylbutroxy)-3-hydroxy-3-methylbutoxy]psoralen blocks depolarization-induced calcium uptake in pituitary cells. 8-[2-(3-Methylbutroxy)-3-hydroxy-3-methylbutoxy]psoralen can be used for research on anti-inflammatory and analgesic activities .

Cat. No.	Product Name	Chemical Structure

HY-10582S

Flurbiprofen-d3

Flurbiprofen-d₃ is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer .

HY-10582S1

Flurbiprofen-d5

Flurbiprofen-d₅ is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer .

HY-10582S3

Flurbiprofen-d4

Flurbiprofen-d₄ is deuterated labeled Flurbiprofen (HY-10582). Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer .

HY-10582S2

Flurbiprofen-13C,d3

Flurbiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer .

HY-18981S

Decursin-d6

Decursin-d₆ ((+)-Decursin-d₆) is the deuterium labeled Decursin (HY-18981). Decursin ((+)-Decursin) is a potent anti-tumor agent. Decursin also is a cytotoxic agent and a potent protein kinase C activator. Decursin induces apoptosis and cell cycle arrest at G1 phase. Decursin decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h. Decursin inhibits cell proliferation and migration. Decursin shows anti-tumor, anti-inflammatory and analgesic activities .

Cat. No.	Product Name		Classification

HY-159562

COX-2-IN-46		Azide
COX-2-IN-46 (compound 5m) is an anti-inflammatory agent with potent analgesic activity. COX-2-IN-46 exhibits a significant inhibitory effect on COX-2 (IC₅₀=87.74 nM) .

HY-159561

COX-1-IN-2		Azide
COX-1-IN-2 (compound 5h) is an anti-inflammatory agent with potent analgesic activity. COX-1-IN-2 exhibits a significant inhibitory effect on COX-1 (IC₅₀=38.76 nM) .

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