1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. SDZ NKT 343

SDZ NKT 343 

Cat. No.: HY-108480
Handling Instructions

SDZ NKT 343 is a selective, orally active NK1 receptor antagonist with an IC50 of 0.62 nM against human NK1 receptor. SDZ NKT 343 has good analgesic activity.

For research use only. We do not sell to patients.

SDZ NKT 343 Chemical Structure

SDZ NKT 343 Chemical Structure

CAS No. : 180046-99-5

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Description

SDZ NKT 343 is a selective, orally active NK1 receptor antagonist with an IC50 of 0.62 nM against human NK1 receptor. SDZ NKT 343 has good analgesic activity[1][2].

IC50 & Target

hNK1

0.62 nM (IC50)

hNK2

0.52 μM (Ki)

hNK3

3.4 μM (Ki)

In Vitro

SDZ NKT 343 shows a markedly lower affinity at rat NK1 receptors in whole forebrain membranes (IC50=451+139 nM)[1].
SDZ NKT 343 shows weak affinity to human NK2 and NK3 receptors in transfected Cos-7 cells (Ki of 0.52+0.04 μM and 3.4+1.2 μM respectively)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SDZ NKT 343 antagonized [Sar9]SP sulphone-evoked bronchoconstriction (70% reduction at 0.4 mg/kg, i.v.) in anaesthetized guinea-pigs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

579.65

Formula

C33H33N5O5

CAS No.
SMILES

O=C(NC([[email protected]]1N(C(NC2=CC=CC=C2[N+]([O-])=O)=O)CCC1)=O)[[email protected]](CC3=CC=C4C=CC=CC4=C3)N(C)CC5=CC=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
SDZ NKT 343
Cat. No.:
HY-108480
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