180046-99-5
180046-99-5
Chemical Structure
SDZ NKT 343
- CAS No.: 180046-99-5
- Formula:C33H33N5O5
- Molecular Weight:579.65
IUPAC Name: (S)-N2-((S)-2-(benzyl(methyl)amino)-3-(naphthalen-2-yl)propanoyl)-N1-(2-nitrophenyl)pyrrolidine-1,2-dicarboxamide
InChIKey: UYLNUSYIZWUOLL-KYJUHHDHSA-N
SMILES: O=C(NC([C@H]1N(C(NC2=CC=CC=C2[N+]([O-])=O)=O)CCC1)=O)[C@H](CC3=CC=C4C=CC=CC4=C3)N(C)CC5=CC=CC=C5
Biological Activity: SDZ NKT 343 is a selective, orally active NK1 receptor antagonist with an IC50 of 0.62 nM against human NK1 receptor. SDZ NKT 343 has good analgesic activity[1][2].
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SDZ NKT 343 | SDZ NKT 343 is a selective, orally active NK1 receptor antagonist with an IC50 of 0.62 nM against human NK1 receptor. SDZ NKT 343 has good analgesic activity. | |||||||||||||||||||||
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References
- [1]. Walpole CS, et al. Comparative, general pharmacology of SDZ NKT 343, a novel, selective NK1 receptor antagonist. Br J Pharmacol. 1998 May;124(1):83-92. [Content Brief]
- [2]. Walpole C, et al. 2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N - methylamide (SDZ NKT 343), a potent human NK1 tachykinin receptor antagonist with good oral analgesic activity in chronic pain models. J Med Chem. 1998 Aug 13;41(17) [Content Brief]
