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Cat. No.: HY-120938

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JYL-273 analog-1

JYL-273 analog-1 (Compound 28, Example 45) is a potent transient receptor potential ion channel (TRP channel) (TRPV1) agonist (K_i = 10.8 nM). JYL-273 analog-1 has analgesic activity (PBQ-induced writhing test: ED₅₀ = 1.0 mg/kg). JYL-273 analog-1 can be used for analgesia studies.

For research use only. We do not sell to patients.

CAS No.: 289902-71-2
Formula: C₂₈H₄₀N₂O₄S
Molecular Weight:500.69

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

JYL-273 analog-1 Chemical Structure

CAS No.: 289902-71-2

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

All TRP Channel Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	1.34 nM Compound: 2	Agonist activity at human TRPV1 expressed in CHO cells assessed as 45Ca2+ uptake after 20 mins by liquid scintillation counting analysis Agonist activity at human TRPV1 expressed in CHO cells assessed as 45Ca2+ uptake after 20 mins by liquid scintillation counting analysis	[PMID: 24321344]
CHO	EC₅₀	2.83 nM Compound: 1	Agonist activity at rat TRPV1 expressed in CHO cells assessed as maximal calcium uptake Agonist activity at rat TRPV1 expressed in CHO cells assessed as maximal calcium uptake	[PMID: 17035013]
CHO	EC₅₀	2.83 nM Compound: 2	In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cells In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cells	[PMID: 12825950]

Chemical Information

CAS No. 289902-71-2
Molecular Weight 500.69
Formula C₂₈H₄₀N₂O₄S
SMILES

CC(C)(C)C(OCC(CNC(NCC1=CC=C(O)C(OC)=C1)=S)CC2=CC=C(C(C)(C)C)C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jeewoo Lee, et al. Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof. WO2000050387. 2001-08-22.

[2]. Lee J, et al. N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics. Bioorg Med Chem. 2001 Jan;9(1):19-32. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
Purity & Documentation
References

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JYL-273 analog-1

All TRP Channel Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JYL-273 analog-1 Related Classifications

HY-120938 Related Classifications