289902-71-2
289902-71-2
Chemical Structure
JYL-273 analog-1
- CAS No.: 289902-71-2
- Formula:C28H40N2O4S
- Molecular Weight:500.69
IUPAC Name: 2-(4-(tert-butyl)benzyl)-3-(3-(4-hydroxy-3-methoxybenzyl)thioureido)propyl pivalate
InChIKey: TVYDDDOENZEUAG-UHFFFAOYSA-N
SMILES: CC(C)(C)C(OCC(CNC(NCC1=CC=C(O)C(OC)=C1)=S)CC2=CC=C(C(C)(C)C)C=C2)=O
Biological Activity: JYL-273 analog-1 (Compound 28, Example 45) is a potent transient receptor potential ion channel (TRP channel) (TRPV1) agonist (Ki = 10.8 nM). JYL-273 analog-1 has analgesic activity (PBQ-induced writhing test: ED50 = 1.0 mg/kg). JYL-273 analog-1 can be used for analgesia studies[1][2].
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JYL-273 analog-1 | JYL-273 analog-1 (Compound 28, Example 45) is a potent transient receptor potential ion channel (TRP channel) (TRPV1) agonist (Ki = 10.8 nM). JYL-273 analog-1 has analgesic activity (PBQ-induced writhing test: ED50 = 1.0 mg/kg). JYL-273 analog-1 can be used for analgesia studies. | |||||||||||||||||||||
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References
- [1]. Jeewoo Lee, et al. Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof. WO2000050387. 2001-08-22.
- [2]. Lee J, et al. N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics. Bioorg Med Chem. 2001 Jan;9(1):19-32. [Content Brief]
