Nav1.7-IN-13
Nav1.7-IN-13 (compound 3g) is a sodium channel inhibitor that significantly inhibits Veratridine (HY-N6691)-induced neuronal activity. Nav1.7-IN-13 inhibits total Na+ current in DRG neurons in a concentration-dependent manner; slows down the activation of Navs. Nav1.7-IN-13 significantly alleviated mechanical pain behavior in a rat model of nerve injury (SNI) and had analgesic activity.
For research use only. We do not sell to patients.
- CAS No.: 2776235-57-3
- Formula: C23H22BrNO5
- Molecular Weight:472.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Nav1.7 |
Nav1.7-IN-13 (compound 3g) blocks the open state in a hyperexcitable state. Nav1.7-IN-13 (50-150 μM; 16 h) dose-dependently inhibits sodium channel activation in rat DRG neurons and does not inhibit hERG channel current at a concentration of 150 μM, which is safe[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2776235-57-3
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Molecular Weight 472.33
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Formula C23H22BrNO5
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SMILES
C/C(C)=C/CN1C2=CC(Br)=CC=C2[C@@]([C@]3(C(OC)=O)OC(C=CC=C4)=C4C3)(O)C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nav1.7-IN-13 Related Classifications
HY-162347 Related Classifications
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