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Cat. No.: HY-137525

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NTRC-808

NTRC-808 is a nonpeptide selective GPCR neurotensin receptor type 2 (NTS2) partial agonist with an EC₅₀ of 14 nM and K_i of 88 nM. NTRC-808 has higher selectivity for NTS2 than for NTS1. NTRC-808 has antipsychotic and analgesic activity.

For research use only. We do not sell to patients.

CAS No.: 1643879-88-2
Formula: C₂₃H₂₄ClN₃O₅
Molecular Weight:457.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

NTRC-808 Chemical Structure

CAS No.: 1643879-88-2

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Neurotensin Receptor Isoforms :

NTR1
NTR2

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	EC₅₀	14 nM Compound: 9, NTRC-808	Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assay Agonist activity at rat neurotensin receptor type 2 expressed in CHOK1 cells assessed as increase in calcium release by FLIPR assay	[PMID: 25499438]

Chemical Information

CAS No. 1643879-88-2
Molecular Weight 457.91
Formula C₂₃H₂₄ClN₃O₅
SMILES

CC(C)C[C@@H](C(O)=O)NC(C1=NC(C2=C(OC)C=CC=C2OC)=C3C=C(Cl)C=CC3=N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. J. B. Thomas et al. Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2. Med. Chem. Lett. 25 (2015) 292-296.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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NTRC-808

All Neurotensin Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NTRC-808 Related Classifications

HY-137525 Related Classifications