2. GPCR/G Protein
  3. Hydroxycarboxylic Acid Receptor (HCAR)
  4. FCH-2296413

FCH-2296413 is a potent and selective hydroxycarboxylic acid receptor (HCAR) agonist with an EC50 of 4.4-8.6 nM. FCH-2296413 exhibits analgesic activity and can be used for the research of peripheral pain-related diseases.

For research use only. We do not sell to patients.

FCH-2296413

FCH-2296413 Chemical Structure

CAS No. : 1229028-63-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Customer Review

Based on 1 publication(s) in Google Scholar

FCH-2296413 Related Antibodies

Top Publications Citing Use of Products

View All Hydroxycarboxylic Acid Receptor (HCAR) Isoform Specific Products:

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HCAR1 HCAR2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

FCH-2296413 is a potent and selective hydroxycarboxylic acid receptor (HCAR) agonist with an EC50 of 4.4-8.6 nM. FCH-2296413 exhibits analgesic activity and can be used for the research of peripheral pain-related diseases[1].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
0.21 μM
Compound: (+/-)17a
Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay
Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assay
[PMID: 20363624]
Molecular Weight

188.19

Formula

C8H8N6
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

C1(C2=NNC3=C2CC4CC34)=NN=NN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 15 mg/mL (79.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3138 mL 26.5689 mL 53.1378 mL
5 mM 1.0628 mL 5.3138 mL 10.6276 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.3138 mL 26.5689 mL 53.1378 mL 132.8445 mL
5 mM 1.0628 mL 5.3138 mL 10.6276 mL 26.5689 mL
10 mM 0.5314 mL 2.6569 mL 5.3138 mL 13.2844 mL
15 mM 0.3543 mL 1.7713 mL 3.5425 mL 8.8563 mL
20 mM 0.2657 mL 1.3284 mL 2.6569 mL 6.6422 mL
25 mM 0.2126 mL 1.0628 mL 2.1255 mL 5.3138 mL
30 mM 0.1771 mL 0.8856 mL 1.7713 mL 4.4281 mL
40 mM 0.1328 mL 0.6642 mL 1.3284 mL 3.3211 mL
50 mM 0.1063 mL 0.5314 mL 1.0628 mL 2.6569 mL
60 mM 0.0886 mL 0.4428 mL 0.8856 mL 2.2141 mL
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FCH-2296413 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FCH-22964131229028-63-0FCH2296413FCH 2296413Hydroxycarboxylic Acid Receptor (HCAR)Inhibitorinhibitorinhibit

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