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Cat. No.: HY-N2573A

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Corydalmine hydrochloride

(Synonyms: L-Corydalmine hydrochloride; TLZ-16-CL)

Corydalmine hydrochloride inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine hydrochloride acts as an oral analgesic agent, exhibiting potent analgesic activity. Corydalmine hydrochloride alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway.

For research use only. We do not sell to patients.

CAS No.: 2428393-60-4
Formula: C₂₀H₂₄ClNO₄
Molecular Weight:377.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Corydalmine hydrochloride Chemical Structure

CAS No.: 2428393-60-4

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
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Biological Activity

Description

Corydalmine hydrochloride inhibits spore germination of some plant pathogenic as well as saprophytic fungi^[1]. Corydalmine hydrochloride acts as an oral analgesic agent, exhibiting potent analgesic activity^[2]. Corydalmine hydrochloride alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway^[3].

All CXCR Isoforms :

In Vivo

Corydalmine hydrochloride is a potent analgesic agent, in cynomolgus monkey, beagle dog, rat and mouse liver microsomes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2428393-60-4
Molecular Weight 377.86
Formula C₂₀H₂₄ClNO₄
SMILES

OC1=CC=C2C(CN3CCC4=CC(OC)=C(OC)C=C4[C@]3([H])C2)=C1OC.[H]Cl
Synonyms

L-Corydalmine hydrochloride; TLZ-16-CL
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Basha SA, Jha RN, Pandey VB, Singh UP. Effect of 1-corydalmine,an Alkaloid Isolated from Corydalis chaerophylla Roots on Spore Germination of Some Fungi. Mycobiology. 2007;35(2):69-71. [Content Brief]

[2]. Tang X, Di X, Zhong Z, et al. In vitro metabolism of l-corydalmine, a potent analgesic drug, in human, cynomolgus monkey, beagle dog, rat and mouse liver microsomes. J Pharm Biomed Anal. 2016;128:98-105. [Content Brief]

[3]. Zhou L, Hu Y, Li C, et al. Levo-corydalmine alleviates vincristine-induced neuropathic pain in mice by inhibiting an NF-kappa B-dependent CXCL1/CXCR2 signaling pathway. Neuropharmacology. 2018;135:34-47. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
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- In Vivo
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Purity & Documentation
References

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Corydalmine hydrochloride

All CXCR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Corydalmine hydrochloride Related Classifications

HY-N2573A Related Classifications