Corydalmine hydrochloride  (Synonyms: L-Corydalmine hydrochloride; TLZ-16-CL)

Corydalmine hydrochloride inhibits spore germination of some plant pathogenic as well as saprophytic fungi^[1]. Corydalmine hydrochloride acts as an oral analgesic agent, exhibiting potent analgesic activity^[2]. Corydalmine hydrochloride alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway^[3].

Corydalmine hydrochloride is a potent analgesic agent, in cynomolgus monkey, beagle dog, rat and mouse liver microsomes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

377.86

C₂₀H₂₄ClNO₄

2428393-60-4

OC1=CC=C2C(CN3CCC4=CC(OC)=C(OC)C=C4[C@]3([H])C2)=C1OC.[H]Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Basha SA, Jha RN, Pandey VB, Singh UP. Effect of 1-corydalmine,an Alkaloid Isolated from Corydalis chaerophylla Roots on Spore Germination of Some Fungi. Mycobiology. 2007;35(2):69-71.  [Content Brief]

  [2]. Tang X, Di X, Zhong Z, et al. In vitro metabolism of l-corydalmine, a potent analgesic drug, in human, cynomolgus monkey, beagle dog, rat and mouse liver microsomes. J Pharm Biomed Anal. 2016;128:98-105.  [Content Brief]

  [3]. Zhou L, Hu Y, Li C, et al. Levo-corydalmine alleviates vincristine-induced neuropathic pain in mice by inhibiting an NF-kappa B-dependent CXCL1/CXCR2 signaling pathway. Neuropharmacology. 2018;135:34-47.  [Content Brief]