Sigma-1 receptor antagonist 5
Sigma-1 receptor antagonist 5 (compound 12)，a 4-pyridylpiperidine derivative with analgesic activity，is an antagonist of sigma receptor (Ki=4.5 nM (σ1R)，10 nM (σ2R)) and histamine H3 (hH3R，Ki=7.7 nM，IC50=215 nM). Sigma-1 receptor antagonist 5 suppresses Capsaicin-induced nociception with antinociceptive activity and shows potent efficacy in nociceptive and neuropathic pain models.
For research use only. We do not sell to patients.
- CAS No.: 2952808-33-0
- Formula: C26H27N3O
- Molecular Weight:397.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ki: 7.7 nM (σ1R), 4.5 Nm (σ2R), 10 nM (hH3R)[1]
Chemical Information
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CAS No. 2952808-33-0
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Molecular Weight 397.51
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Formula C26H27N3O
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SMILES
N#CC1=CC=C(C2=CC=C(OCCCN3CCC(C4=CC=NC=C4)CC3)C=C2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sigma-1 receptor antagonist 5 Related Classifications
HY-149335 Related Classifications
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