2952808-33-0
2952808-33-0
Chemical Structure
Sigma-1 receptor antagonist 5
- CAS No.: 2952808-33-0
- Formula:C26H27N3O
- Molecular Weight:397.51
InChIKey: BYUXJHZOSYXPSS-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(C2=CC=C(OCCCN3CCC(C4=CC=NC=C4)CC3)C=C2)C=C1
Biological Activity: Sigma-1 receptor antagonist 5 (compound 12)，a 4-pyridylpiperidine derivative with analgesic activity，is an antagonist of sigma receptor (Ki=4.5 nM (σ1R)，10 nM (σ2R)) and histamine H3 (hH3R，Ki=7.7 nM，IC50=215 nM). Sigma-1 receptor antagonist 5 suppresses Capsaicin-induced nociception with antinociceptive activity and shows potent efficacy in nociceptive and neuropathic pain models[1].
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Sigma-1 receptor antagonist 5 | Sigma-1 receptor antagonist 5 (compound 12)，a 4-pyridylpiperidine derivative with analgesic activity，is an antagonist of sigma receptor (Ki=4.5 nM (σ1R)，10 nM (σ2R)) and histamine H3 (hH3R，Ki=7.7 nM，IC50=215 nM). Sigma-1 receptor antagonist 5 suppresses Capsaicin-induced nociception with antinociceptive activity and shows potent efficacy in nociceptive and neuropathic pain models. | |||||||||||||||||||||
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