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DE

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101

Inhibitors & Agonists

2

Screening Libraries

2

Fluorescent Dye

6

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2

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3

Inhibitory Antibodies

19

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4

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21

Isotope-Labeled Compounds

1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-120734

    DE-795

    Fungal Infection
    Quinoxyfen (DE-795) is a powdery mildew fungicide .
    Quinoxyfen
  • HY-111406

    DE-117

    Prostaglandin Receptor Inflammation/Immunology
    Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration, and Omidenepag is a highly selective EP2 receptor agonist. Omidenepag isopropyl shows only weak affinity for EP1, EP2, and FP receptors. Omidenepag isopropyl is under development for the treatment of glaucoma as an intraocular pressure (IOP)-lowering agent.
    Omidenepag isopropyl
  • HY-N7803

    Apoptosis Cancer
    De-O-Methyllasiodiplodin, a cytotoxic compound, can be isolated from Ludwigia hyssopifolia. De-O-Methyllasiodiplodin inhibits Hep-2 cell growth by inducing apoptosis .
    <em>De</em>-O-Methyllasiodiplodin
  • HY-N3693

    Others Inflammation/Immunology
    De-4’-O-methylyangambin is a lignan that can be isolated from Z. armatum. lignans are reported to has anti-inflammatory activity .
    <em>De</em>-4′-O-methylyangambin
  • HY-W145658

    Heparamine sodium salt

    Biochemical Assay Reagents Others
    De-N-sulfated heparin (Heparin I-H) sodium salt is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    <em>De</em>-N-sulfated heparin sodium salt
  • HY-P99494

    TRC105; DE-122

    TGF-beta/Smad Cancer
    Carotuximab (TRC105) is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antineoplastic actions .
    Carotuximab
  • HY-W040303

    DE-498; XRD-498

    Others Others
    Flumetsulam is pre- and postemergence herbicide, which is susceptible to dissipate in corn ecosystem with half-live less than 8.7 days .
    Flumetsulam
  • HY-W145669

    DE-beta-Cyd

    Biochemical Assay Reagents Others
    Heptakis-(2,6-di-O-ethyl)-β-cyclodextrin is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Heptakis-(2,6-di-O-ethyl)-β-cyclodextrin
  • HY-120734S

    Legend-d4; DE 795-d4

    Isotope-Labeled Compounds Others
    Quinoxyfen-d4 is the deuterium labeled Quinoxyfen[1].
    Quinoxyfen-d4
  • HY-117287
    Deucravacitinib
    10+ Cited Publications

    BMS-986165

    JAK Interleukin Related IFNAR Inflammation/Immunology
    Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain. Deucravacitinib inhibits IL-12/23 and type I IFN pathways. Deucravacitinib, the FDA's world first de novo deuterium, is available for study in moderate to severe plaque psoriasis .
    Deucravacitinib
  • HY-P10008

    Cathepsin Cancer
    Cathepsin D/E Substrate, Fluorogenic, 11 amino acid peptide, is a selective substrate for cathepsins D and E. Cathepsin D/E Substrate, Fluorogenic does not act as a substrate for cathepsins B, H, or L .
    Cathepsin <em>D/E</em> Substrate, Fluorogenic
  • HY-N1013

    Others Others
    11,12-De(methylenedioxy)danuphylline is an indole alkaloid compound isolated from the leaves and stems of Kopsia officinalis .
    11,12-<em>De</em>(methylenedioxy)danuphylline
  • HY-131510

    SNARF-DE

    Fluorescent Dye Others
    Chromoionophore XIII (SNARF-DE) is a pH senor that enables excitation with red light. Chromoionophore XIII functionality renders the indicator molecule lipophilic and water-insoluble but also prevents lactonization of the dye in an apolar environment .
    Chromoionophore XIII
  • HY-P99578

    HL036337; HBM9036

    TNF Receptor Others
    Tanfanercept (HL036337) is an anti-TNF-α monoclonal antibody. Tanfanercept is effective in ameliorating corneal erosions in a dry eye (DE) mouse model .
    Tanfanercept
  • HY-147091

    Ligands for Target Protein for PROTAC Cancer
    Tazemetostat de(methyl morpholine)-COOH (compound 7) is a ligand for the PROTAC target protein EZH2, which can be used to synthesis of EZH2 degraders (PROTACs). EZH2 degraders have potent cell viability inhibition in diffuse large B-cell lymphoma (DLBCL) and other subtypes of lymphoma .
    Tazemetostat <em>de</em>(methyl morpholine)-COOH
  • HY-145949

    Drug Metabolite Infection
    Remdesivir de(ethylbutyl 2-aminopropanoate) is an impurity of Remdesivir. Remdesivir, a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro .
    Remdesivir <em>de</em>(ethylbutyl 2-aminopropanoate)
  • HY-147090

    Histone Methyltransferase Cancer
    Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b) is an EZH2 degrader and can be used for the research of lymphoma .
    Tazemetostat <em>de</em>(methylene morpholine)-O-C3-O-C-COOH
  • HY-132604

    ARO-AAT

    Small Interfering RNA (siRNA) Metabolic Disease
    Fazirsiran (ARO-AAT) is a second-generation RNAi agent. Fazirsiran consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively degrade Alpha1-antitrypsin (AAT) mRNA by RNAi and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes . Fazirsiran can be used in the study of Alpha-1 Antitrypsin Deficiency (AATD) liver disease.
    Fazirsiran
  • HY-152661

    Nucleoside Antimetabolite/Analog Others
    2-Hydroxy-2’-de oxy-2’-fluoro-beta-D-arabino adenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    2-Hydroxy-2’-deoxy-2’-fluoro-beta-D-arabino adenosine
  • HY-18762

    6-thio-dG; β-TGdR

    DNA/RNA Synthesis Cancer
    6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase.
    6-Thio-2'-Deoxyguanosine
  • HY-103038
    ML327
    4 Publications Verification

    c-Myc Autophagy Cancer
    ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).
    ML327
  • HY-N2327

    Oleamide is an endogenous fatty acid amide which can be synthesized de novo in the mammalian nervous system, and has been detected in human plasma.
    Oleamide
  • HY-160096

    DNA-PK Cancer
    DNA-PK-IN-11 is a DNA-PK inhibitor with an IC50 of <0.1 μM (DE102010035744A1; compound 36) .
    DNA-PK-IN-11
  • HY-E70104

    Others Others
    α-Rhamnosidase is a glycoside hydrolase. α-Rhamnosidase is able to finish the enzymatic de-glycosylation of many nature flavone glycosides .
    α-Rhamnosidase
  • HY-142080

    Bacterial Infection
    Pimeloyl-CoA is a biotin precursor of Escherichia coli. Pimeloyl-CoA can be used for the research of the pathway of de novo biotin biosynthesis in Escherichia coli .
    Pimeloyl-CoA
  • HY-P4584

    Biochemical Assay Reagents Others
    TRH-βNA is a substrate for determining the membrane TRH-deamidating enzyme (TRH-DE) activity and membrane pyroglutamyl aminopeptidase II (PPII) activity .
    TRH-βNA
  • HY-W012078
    5-Methyl-2'-deoxycytidine
    1 Publications Verification

    5-MethylDEoxycytidine

    DNA Methyltransferase Endogenous Metabolite Others
    5-Methyl-2'-deoxycytidine in single-stranded DNA can act in cis to signal de novo DNA methylation .
    5-Methyl-2'-deoxycytidine
  • HY-N6723

    Acyltransferase Infection
    Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis .
    Fumonisin B2
  • HY-107754

    Potassium Channel Cardiovascular Disease
    Cesium chloride is a blocker of potassium channel. Cesium chloride prevents the decrease of Na + transport produced by Alloxan . Cesium chloride has induced cardiac arrhythmias, including torsade de pointes in animal models .
    Cesium chloride
  • HY-133154

    CAIR; 4-Carboxy-AIR

    Endogenous Metabolite Infection
    Carboxyaminoimidazole ribotide (CAIR) is a metabolite of E. coli. Carboxyaminoimidazole ribotide can be used to detect distinctive features of E. coli PurE active site and synthesis fungal de novo purine .
    Carboxyaminoimidazole ribotide
  • HY-W145483

    N-Acetyl-DE-O-sulfated heparin (Heparin IV-A) (sodium)

    Biochemical Assay Reagents Others
    Heparin IV-A sodium is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Heparin IV-A sodium
  • HY-14538B

    Others Neurological Disease
    Haloperidol lactate is a potent antipsychotic agent. Haloperidol lactate can be used in acute and chronic schizophrenia and gilles de la tourette's syndrome. Haloperidol lactate has the potential for the research of psychotic disorders .
    Haloperidol lactate
  • HY-N2327R

    Endogenous Metabolite Others
    Oleamide (Standard) is the analytical standard of Oleamide. This product is intended for research and analytical applications. Oleamide is an endogenous fatty acid amide which can be synthesized de novo in the mammalian nervous system, and has been detected in human plasma.
    Oleamide (Standard)
  • HY-157528

    Endogenous Metabolite Cancer
    CJ28 is a cortisol biosynthesis inhibitor that significantly inhibits basal and stimulated cortisol production in human adrenal carcinoma cell lines. CJ28 exhibits inhibitory effects by reducing steroidogenesis and de novo cholesterol biosynthesis .
    CJ28
  • HY-101981

    5'-​Uridylic acid

    Endogenous Metabolite Others
    Uridine 5'-monophosphate (5'-​Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk .
    Uridine 5'-monophosphate
  • HY-132188

    Endogenous Metabolite Others
    Manganese peroxidase is a heme protein that oxidizes Mn2+ to Mn3+. Manganese peroxidase catalyzes plant lignin de-polymerization. Manganese peroxidase can be used for the biodegradation of hazardous environmental contaminants, and especially for dye wastewater decolorization .
    Manganese peroxidase
  • HY-14526

    543U76; 5,11-Methenyltetrahydrohomofolate

    Others Cancer
    5-DACTHF (543U76) is an inhibitor of purine de novo biosynthesis. 5-DACTHF is a GAR-TFase and AICAR-TFase inhibitor (IC50: 3 and 94 μM). 5-DACTHF is a potent antitumor agent .
    5-DACTHF
  • HY-N6719
    Fumonisin B1
    4 Publications Verification

    Acyltransferase Infection
    Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin .
    Fumonisin B1
  • HY-10250A

    TCN-P sodium

    ATP Synthase Metabolic Disease
    Triciribine phosphate sodium inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate sodium also inhibits IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity .
    Triciribine phosphate sodium
  • HY-110217

    Others Others
    BMS-566419 is an acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase (IMPDH). Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme in the de novo synthesis of guanosine nucleotides. BMS-566419 has clinical utility for the research of transplant rejection .
    BMS-566419
  • HY-126585
    SAICAR
    1 Publications Verification

    Endogenous Metabolite Cancer
    SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC50 of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions .
    SAICAR
  • HY-103073

    TRP Channel Others
    Mesendogen is a TRPM6 inhibitor. Mesendogen enhances the mesoderm and definitive endoderm (DE) differentiations of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Mesendogen can be used for the research of magnesium homeostasis during early embryonic cell development .
    Mesendogen
  • HY-10250

    TCN-P

    ATP Synthase Metabolic Disease
    Triciribine phosphate (TCN-P) inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate also inhibits  IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity .
    Triciribine phosphate
  • HY-123269

    Phosphoglycerate Dehydrogenase (PHGDH) Cancer
    PKUMDL-WQ-2101 is a non-NAD +-competing allosteric phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 34.8 μM. PKUMDL-WQ-2101 exhibits antitumor activity .
    PKUMDL-WQ-2101
  • HY-134433A

    Endogenous Metabolite Metabolic Disease
    GDP-L-fucose disodium is a nucleotide sugar that is a key substrate for the biosynthesis of fucose oligosaccharides. GDP-L-fucose disodium provides the fucose moiety for the oligosaccharides. The formation of GDP-L-fucose disodium occurs through two pathways, the major de novo metabolic pathway and the minor remedial metabolic pathway .
    GDP-L-fucose disodium
  • HY-B0199
    Mycophenolate Mofetil
    5+ Cited Publications

    RS 61443; TM-MMF

    Drug Metabolite Apoptosis Endogenous Metabolite Bacterial Cancer
    Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation .
    Mycophenolate Mofetil
  • HY-117058

    (6S)-DDATHF

    Antifolate Cancer
    LY243246 ((6S)-DDATHF), the 6S diastereomer of DDATHF, is a potent competitive inhibitor of 5’-phosphoribosylglycinamide formyltransferase (GAR transformylase). 6R- and 6S-diastereomers of DDATHF are remarkably similar and equiactive antimetabolites inhibitory to de novo purine synthesis .
    LY243246
  • HY-100954
    2,4-Diamino-6-hydroxypyrimidine
    1 Publications Verification

    2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis). 2,4-Diamino-6-hydroxypyrimidine blocks Tetrahydrobiopterin (BH4) synthesis and suppresses NO production .
    2,4-Diamino-6-hydroxypyrimidine
  • HY-122122
    ML-60218
    3 Publications Verification

    DNA/RNA Synthesis Infection Cancer
    ML-60218 is a broad-spectrum RNA pol III inhibitor, with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and to hamper the formation of new ones without the need for de novo transcription of cellular RNAs .
    ML-60218
  • HY-114879
    DDAO
    1 Publications Verification

    Fluorescent Dye Cancer
    DDAO is a promising near-infrared (NIR) red fluorescent probewith tunable excitation wavelength (600-650nm) and longemission wavelength(λem=656nm). DDAO can de desiged for detection of the activities of different enzymes such asβ-galactosidase,sulfatase, proteinphosphatase2A,carboxylesterase 2, humanalbumin andesterases .
    DDAO

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