Tazemetostat de(methyl morpholine)-COOH

Cat. No.: HY-147091 Purity: 98.50%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tazemetostat de(methyl morpholine)-COOH (compound 7) is a ligand for the PROTAC target protein EZH2, which can be used to synthesis of EZH2 degraders (PROTACs). EZH2 degraders have potent cell viability inhibition in diffuse large B-cell lymphoma (DLBCL) and other subtypes of lymphoma.

For research use only. We do not sell to patients.

Tazemetostat de(methyl morpholine)-COOH Chemical Structure

CAS No. : 2685873-44-1

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 456	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 456	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 600	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1150	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1850	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2800	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

517.62

Formula

C₃₀H₃₅N₃O₅

CAS No.

2685873-44-1

Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(C1=CC=C(C2=CC(C(NCC3=C(C)C=C(C)NC3=O)=O)=C(C)C(N(C4CCOCC4)CC)=C2)C=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 220 mg/mL (425.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9319 mL	9.6596 mL	19.3192 mL
5 mM	0.3864 mL	1.9319 mL	3.8638 mL
10 mM	0.1932 mL	0.9660 mL	1.9319 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.50%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (254 KB) HNMR (200 KB) RP-HPLC (263 KB) LCMS (131 KB)

Handling Instructions (2659 KB)

References

[1]. Tu Y, Sun Y, et al. Design, Synthesis, and Evaluation of VHL-Based EZH2 Degraders to Enhance Therapeutic Activity against Lymphoma. J Med Chem. 2021 Jul 22;64(14):10167-10184. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9319 mL	9.6596 mL	19.3192 mL	48.2980 mL
	5 mM	0.3864 mL	1.9319 mL	3.8638 mL	9.6596 mL
	10 mM	0.1932 mL	0.9660 mL	1.9319 mL	4.8298 mL
	15 mM	0.1288 mL	0.6440 mL	1.2879 mL	3.2199 mL
	20 mM	0.0966 mL	0.4830 mL	0.9660 mL	2.4149 mL
	25 mM	0.0773 mL	0.3864 mL	0.7728 mL	1.9319 mL
	30 mM	0.0644 mL	0.3220 mL	0.6440 mL	1.6099 mL
	40 mM	0.0483 mL	0.2415 mL	0.4830 mL	1.2074 mL
	50 mM	0.0386 mL	0.1932 mL	0.3864 mL	0.9660 mL
	60 mM	0.0322 mL	0.1610 mL	0.3220 mL	0.8050 mL
	80 mM	0.0241 mL	0.1207 mL	0.2415 mL	0.6037 mL
	100 mM	0.0193 mL	0.0966 mL	0.1932 mL	0.4830 mL