Tazemetostat de(methyl morpholine)-COOH
Based on 1 Customer Validation
Tazemetostat de(methyl morpholine)-COOH (compound 7) is a ligand for the PROTAC target protein EZH2, which can be used to synthesis of EZH2 degraders (PROTACs). EZH2 degraders have potent cell viability inhibition in diffuse large B-cell lymphoma (DLBCL) and other subtypes of lymphoma.
For research use only. We do not sell to patients.
- Purity: 98.15%
- CAS No.: 2685873-44-1
- Formula: C30H35N3O5
- Molecular Weight:517.62
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| GBM | IC50 |
79.81 μM
Compound: TAZ; Cpd I
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Cell growth inhibition of TMZ-resistant patient-derived human GBM cells assessed as cell viability incubated for 72 hrs by CCK8 assay
Cell growth inhibition of TMZ-resistant patient-derived human GBM cells assessed as cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 38285511] |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2685873-44-1
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Appearance Solid
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Molecular Weight 517.62
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Formula C30H35N3O5
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Color Off-white to yellow
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SMILES
O=C(C1=CC=C(C2=CC(C(NCC3=C(C)C=C(C)NC3=O)=O)=C(C)C(N(C4CCOCC4)CC)=C2)C=C1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 220 mg/mL (425.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9319 mL | 9.6596 mL | 19.3192 mL | 48.2980 mL |
| 5 mM | 0.3864 mL | 1.9319 mL | 3.8638 mL | 9.6596 mL | |
| 10 mM | 0.1932 mL | 0.9660 mL | 1.9319 mL | 4.8298 mL | |
| 15 mM | 0.1288 mL | 0.6440 mL | 1.2879 mL | 3.2199 mL | |
| 20 mM | 0.0966 mL | 0.4830 mL | 0.9660 mL | 2.4149 mL | |
| 25 mM | 0.0773 mL | 0.3864 mL | 0.7728 mL | 1.9319 mL | |
| 30 mM | 0.0644 mL | 0.3220 mL | 0.6440 mL | 1.6099 mL | |
| 40 mM | 0.0483 mL | 0.2415 mL | 0.4830 mL | 1.2074 mL | |
| 50 mM | 0.0386 mL | 0.1932 mL | 0.3864 mL | 0.9660 mL | |
| 60 mM | 0.0322 mL | 0.1610 mL | 0.3220 mL | 0.8050 mL | |
| 80 mM | 0.0241 mL | 0.1207 mL | 0.2415 mL | 0.6037 mL | |
| 100 mM | 0.0193 mL | 0.0966 mL | 0.1932 mL | 0.4830 mL |
Tazemetostat de(methyl morpholine)-COOH Related Classifications
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