1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. ML-60218

ML-60218 

Cat. No.: HY-122122 Purity: >99.0%
Handling Instructions

ML-60218 is a broad-spectrum RNA pol III inhibitor, with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and to hamper the formation of new ones without the need for de novo transcription of cellular RNAs.

For research use only. We do not sell to patients.

ML-60218 Chemical Structure

ML-60218 Chemical Structure

CAS No. : 577784-91-9

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Description

ML-60218 is a broad-spectrum RNA pol III inhibitor, with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and to hamper the formation of new ones without the need for de novo transcription of cellular RNAs[1][2].

In Vitro

Combination of SAHA and ML-60218 produces enhanced suppression of proliferation in human pancreatic adenocarcinoma by impairing cell cycle progression and inducing apoptosis. ML-60218 reverses SAHA-stimulated tRNA expression in PANC-1 and BxPC-3 cells. ML-60218 enhances the ability of HDAC inhibitors to induce apoptosis and cell cycle arrest[2].
In in vitro transcription assays with purified double-layered particles (DLPs), ML-60218 shows dose-dependent inhibitory activity, indicating the viral nature of its target. ML-60218 is found to interfere with the formation of higher-order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize. Electron microscopy of ML-60218-treated DLPs shows dose-dependent structural damage. ML-60218-mediated (10 μM ) viroplasm disruption causes NSP5 dephosphorylation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

452.38

Formula

C₁₉H₁₅Cl₂N₃O₂S₂

CAS No.

577784-91-9

SMILES

O=S(C1=CC=CC=C1Cl)(NC2=CC(C3=C(C)C4=CC(Cl)=CC=C4S3)=NN2C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-80°C

References

Purity: >99.0%

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Keywords:

ML-60218ML60218ML 60218DNA/RNA Synthesisbroad-spectrumyeastviroplasmstranscriptionInhibitorinhibitorinhibit

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ML-60218
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HY-122122
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