1. Stem Cell/Wnt TGF-beta/Smad
  2. TGF-beta/Smad
  3. Carotuximab

Carotuximab  (Synonyms: TRC105; DE-122)

Cat. No.: HY-P99494 Purity: ≥95.0%
COA

Carotuximab (TRC105) is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antineoplastic actions.

For research use only. We do not sell to patients.

Carotuximab Chemical Structure

Carotuximab Chemical Structure

CAS No. : 1268714-50-6

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Based on 1 publication(s) in Google Scholar

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Description

Carotuximab (TRC105) is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antineoplastic actions[1][2].

In Vitro

Carotuximab (TRC105; 300 μg/mL; pretreatment 1 h, and then co-cultured for 12 h) reduces the 7-Ketocholesterol-induced endoglin (Eng) protein levels and pSmad1/5 and pSmad2/3 signaling in human aortic endothelial cells (HAoECs). Carotuximab mediated blockage of Eng prevented 7-Ketocholesterol-induced adhesion and transmigration of monocytes through endothelial monolayers[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Human aortic endothelial cells (HAoECs)
Concentration: 300 μg/mL
Incubation Time: Pretreatment 1 h, and then co-cultured for 12 h
Result: Reduced the 7-Ketocholesterol-induced Eng protein levels and pSmad1/5 and pSmad2/3 signaling.
In Vivo

Carotuximab (TRC105; 2 mg/kg; i.v; every 3 days; for 8 weeks) along with Decitabine results in a more durable anti-leukemic effect in acute myeloid leukemia (AML) xenografts. And also enhances reactive oxygen species (ROS) activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NSG (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ; 7-8 weeks) injected with primary AML-0032 cells[2]
Dosage: 2 mg/kg
Administration: i.v; every 3 days; for 8 weeks
Result: Along with Decitabine resulted in a more durable anti-leukemic effect in AML xenografts.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Carotuximab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: ≥95.0%

References
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Carotuximab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Carotuximab
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HY-P99494
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