2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. Mesendogen

Mesendogen is a TRPM6 inhibitor. Mesendogen enhances the mesoderm and definitive endoderm (DE) differentiations of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Mesendogen can be used for the research of magnesium homeostasis during early embryonic cell development.

For research use only. We do not sell to patients.

Mesendogen Chemical Structure

Mesendogen Chemical Structure

CAS No. : 864716-85-8

Size Price Stock Quantity
5 mg USD 105 In-stock
10 mg USD 180 In-stock
25 mg USD 390 In-stock
50 mg USD 680 In-stock
100 mg USD 1150 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Mesendogen Related Antibodies

Top Publications Citing Use of Products

View All TRP Channel Isoform Specific Products:

View All Isoforms
TRPC TRPM TRPV TRPA TRPML

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mesendogen is a TRPM6 inhibitor. Mesendogen enhances the mesoderm and definitive endoderm (DE) differentiations of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Mesendogen can be used for the research of magnesium homeostasis during early embryonic cell development[1].

In Vitro

Mesendogen (10 μM) induces hESC mesoderm and endoderm differentiation, and decreases the level of neural differentiation markers[1].
Mesendogen (2.5, 10 and 25 μM; overnight) dose-dependently reduces intracellular magnesium level in H1 hESCs[1].
Mesendogen (10 μM; 7 days) inhibits the neural differentiation activity induced by Dorsomorphin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mesendogen Related Antibodies

Western Blot Analysis[1]

Cell Line: H9 hESCs
Concentration: 10 μM
Incubation Time: 7 days
Result: Downregulated expression levels of pluripotency markers OCT4 and SOX2.
Molecular Weight

400.85

Formula

C18H16ClF3N2OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC(NC1=CC(C(F)(F)F)=CC=C1Cl)=S)C2=CC=C(C(C)C)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (249.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4947 mL 12.4735 mL 24.9470 mL
5 mM 0.4989 mL 2.4947 mL 4.9894 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4947 mL 12.4735 mL 24.9470 mL 62.3675 mL
5 mM 0.4989 mL 2.4947 mL 4.9894 mL 12.4735 mL
10 mM 0.2495 mL 1.2473 mL 2.4947 mL 6.2367 mL
15 mM 0.1663 mL 0.8316 mL 1.6631 mL 4.1578 mL
20 mM 0.1247 mL 0.6237 mL 1.2473 mL 3.1184 mL
25 mM 0.0998 mL 0.4989 mL 0.9979 mL 2.4947 mL
30 mM 0.0832 mL 0.4158 mL 0.8316 mL 2.0789 mL
40 mM 0.0624 mL 0.3118 mL 0.6237 mL 1.5592 mL
50 mM 0.0499 mL 0.2495 mL 0.4989 mL 1.2473 mL
60 mM 0.0416 mL 0.2079 mL 0.4158 mL 1.0395 mL
80 mM 0.0312 mL 0.1559 mL 0.3118 mL 0.7796 mL
100 mM 0.0249 mL 0.1247 mL 0.2495 mL 0.6237 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Mesendogen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mesendogen864716-85-8TRP ChannelTransient receptor potential channelshESChiPSCmagnesium homeostasisembryonic cellInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Mesendogen
Cat. No.:
HY-103073
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.