2. Membrane Transporter/Ion Channel
    Neuronal Signaling
  3. TRP Channel
  4. Mesendogen

Mesendogen 

Cat. No.: HY-103073 Purity: 99.19%
COA Handling Instructions

Mesendogen is a TRPM6 inhibitor. Mesendogen enhances the mesoderm and definitive endoderm (DE) differentiations of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Mesendogen can be used for the research of magnesium homeostasis during early embryonic cell development.

For research use only. We do not sell to patients.

Mesendogen Chemical Structure

Mesendogen Chemical Structure

CAS No. : 864716-85-8

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Based on 1 publication(s) in Google Scholar

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Description

Mesendogen is a TRPM6 inhibitor. Mesendogen enhances the mesoderm and definitive endoderm (DE) differentiations of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Mesendogen can be used for the research of magnesium homeostasis during early embryonic cell development[1].

In Vitro

Mesendogen (10 μM) induces hESC mesoderm and endoderm differentiation, and decreases the level of neural differentiation markers[1].
Mesendogen (2.5, 10 and 25 μM; overnight) dose-dependently reduces intracellular magnesium level in H1 hESCs[1].
Mesendogen (10 μM; 7 days) inhibits the neural differentiation activity induced by Dorsomorphin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: H9 hESCs
Concentration: 10 μM
Incubation Time: 7 days
Result: Downregulated expression levels of pluripotency markers OCT4 and SOX2.
Molecular Weight

400.85

Appearance

Solid

Formula

C18H16ClF3N2OS
CAS No.
SMILES

O=C(NC(NC1=CC(C(F)(F)F)=CC=C1Cl)=S)C2=CC=C(C(C)C)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Mesendogen864716-85-8TRP ChannelTransient receptor potential channelshESChiPSCmagnesium homeostasisembryonic cellInhibitorinhibitorinhibit

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