2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. CJ28

CJ28 is a cortisol biosynthesis inhibitor that significantly inhibits basal and stimulated cortisol production in human adrenal carcinoma cell lines. CJ28 exhibits inhibitory effects by reducing steroidogenesis and de novo cholesterol biosynthesis.

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CJ28

CJ28 Chemical Structure

CAS No. : 3047118-54-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
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Based on 1 publication(s) in Google Scholar

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Description

CJ28 is a cortisol biosynthesis inhibitor that significantly inhibits basal and stimulated cortisol production in human adrenal carcinoma cell lines. CJ28 exhibits inhibitory effects by reducing steroidogenesis and de novo cholesterol biosynthesis[1].

IC50 & Target

Cortisol biosynthesis[1]
Molecular Weight

331.17

Formula

C14H11BrN4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NC2=CC=CC=C2N1)NC3=CC(Br)=CC=C3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (150.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0196 mL 15.0980 mL 30.1960 mL
5 mM 0.6039 mL 3.0196 mL 6.0392 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0196 mL 15.0980 mL 30.1960 mL 75.4899 mL
5 mM 0.6039 mL 3.0196 mL 6.0392 mL 15.0980 mL
10 mM 0.3020 mL 1.5098 mL 3.0196 mL 7.5490 mL
15 mM 0.2013 mL 1.0065 mL 2.0131 mL 5.0327 mL
20 mM 0.1510 mL 0.7549 mL 1.5098 mL 3.7745 mL
25 mM 0.1208 mL 0.6039 mL 1.2078 mL 3.0196 mL
30 mM 0.1007 mL 0.5033 mL 1.0065 mL 2.5163 mL
40 mM 0.0755 mL 0.3774 mL 0.7549 mL 1.8872 mL
50 mM 0.0604 mL 0.3020 mL 0.6039 mL 1.5098 mL
60 mM 0.0503 mL 0.2516 mL 0.5033 mL 1.2582 mL
80 mM 0.0377 mL 0.1887 mL 0.3774 mL 0.9436 mL
100 mM 0.0302 mL 0.1510 mL 0.3020 mL 0.7549 mL
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CJ28 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CJ283047118-54-4CJ 28CJ-28Endogenous MetaboliteAdrenal glandBenzimidazolylureasCorticosteroidCortisolMetyraponeNCI-H295RSteroidogenesisInhibitorinhibitorinhibit

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