1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. Ingenol 3,20-dibenzoate

Ingenol 3,20-dibenzoate 

Cat. No.: HY-137295
Handling Instructions

Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-γ production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells.

For research use only. We do not sell to patients.

Ingenol 3,20-dibenzoate Chemical Structure

Ingenol 3,20-dibenzoate Chemical Structure

CAS No. : 59086-90-7

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-γ production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells[1][2].

In Vitro

Ingenol 3,20-dibenzoate (0-10000 nM; 4 hours) enhanced NK cells (stimulated by A549 cells and H1299 cells) degranulation[2].
Ingenol 3,20-dibenzoate (0.001-10 μg/ml) dose dependently promoted UT-7/EPO cell proliferation with an EC50 of 0.27 μg/ml (485 nM)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ingenol 3,20-dibenzoate (20 μg/mouse; i.p.; on days 3, 7, and 11) lessens the anemia induced by 5-fluorouracil in an in vivo mouse model[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (8–12 weeks old)[3]
Dosage: 20 μg/mouse
Administration: I.p.; On days 3, 7, and 11
Result: Severity of 5-FU–induced anemia was lessened by IDB treatment on days 12 and 20.
Molecular Weight

556.65

Formula

C₃₄H₃₆O₇

CAS No.

59086-90-7

SMILES

O[[email protected]]([[email protected]]1OC(C2=CC=CC=C2)=O)([[email protected]@H](C(COC(C3=CC=CC=C3)=O)=C4)O)[[email protected]]([[email protected]@H]5C)(C=C1C)C([[email protected]]4[[email protected]@](C(C)6C)([H])[[email protected]@]6([H])C5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Ingenol 3,20-dibenzoatePKCProtein kinase CNKcellsNSCLCIFN-γproductionmacromoleculesanemiaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Ingenol 3,20-dibenzoate
Cat. No.:
HY-137295
Quantity:
MCE Japan Authorized Agent: