Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
Based on 1 Customer Validation
Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b) incorporates a ligand for EZH2, and a PROTAC linker, which recruit E3 ligases. Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b) can be used for the research of lymphoma.
For research use only. We do not sell to patients.
- Purity : 99.06%
- CAS No.: 2750350-39-9
- Formula: C34H43N3O7
- Molecular Weight:605.72
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
EZH2 |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2750350-39-9
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Appearance Solid
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Molecular Weight 605.72
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Formula C34H43N3O7
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Color Yellow to brown
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SMILES
O=C(COCCCOC1=CC=C(C2=CC(C(NCC3=C(C)C=C(C)NC3=O)=O)=C(C)C(N(C4CCOCC4)CC)=C2)C=C1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : ≥ 160 mg/mL (264.15 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6509 mL | 8.2546 mL | 16.5093 mL | 41.2732 mL |
| 5 mM | 0.3302 mL | 1.6509 mL | 3.3019 mL | 8.2546 mL | |
| 10 mM | 0.1651 mL | 0.8255 mL | 1.6509 mL | 4.1273 mL | |
| 15 mM | 0.1101 mL | 0.5503 mL | 1.1006 mL | 2.7515 mL | |
| 20 mM | 0.0825 mL | 0.4127 mL | 0.8255 mL | 2.0637 mL | |
| 25 mM | 0.0660 mL | 0.3302 mL | 0.6604 mL | 1.6509 mL | |
| 30 mM | 0.0550 mL | 0.2752 mL | 0.5503 mL | 1.3758 mL | |
| 40 mM | 0.0413 mL | 0.2064 mL | 0.4127 mL | 1.0318 mL | |
| 50 mM | 0.0330 mL | 0.1651 mL | 0.3302 mL | 0.8255 mL | |
| 60 mM | 0.0275 mL | 0.1376 mL | 0.2752 mL | 0.6879 mL | |
| 80 mM | 0.0206 mL | 0.1032 mL | 0.2064 mL | 0.5159 mL | |
| 100 mM | 0.0165 mL | 0.0825 mL | 0.1651 mL | 0.4127 mL |
Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH Related Classifications
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