1. Anti-infection
  2. HBV
  3. Vebicorvir

Vebicorvir (Synonyms: ABI-H0731)

Cat. No.: HY-109195
Handling Instructions

Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor. Vebicorvir (ABI-H0731) suppresses covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM.

For research use only. We do not sell to patients.

Vebicorvir Chemical Structure

Vebicorvir Chemical Structure

CAS No. : 2090064-66-5

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5 mg USD 230 In-stock
Estimated Time of Arrival: December 31
10 mg USD 370 In-stock
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25 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1200 In-stock
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100 mg USD 1800 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor. Vebicorvir (ABI-H0731) suppresses covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM[1].

In Vitro

Vebicorvir (ABI-H0731) demonstrates inhibition of pgRNA, HBeAg, and HBsAg production, with EC50s of 2.68 μM, 4.95 μM, and 7.30 μM, respectively[1].
Vebicorvir (ABI-H0731) is an inhibitor of pgRNA encapsidation and rcDNA synthesis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

After i.v. administration, the drug rapidly distributes and decayes in a biphasic manner in all species tested. Plasma clearance values of ABI-H0731 were 8.05, 10.1, 14.7, and 4.86 ml/min/kg, representing 9, 16, 47, and 11% of liver blood flow, in mouse, rat, dog, and monkey, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

467.44

Formula

C₁₉H₁₂F₃N₃O₄S₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (213.93 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1393 mL 10.6966 mL 21.3931 mL
5 mM 0.4279 mL 2.1393 mL 4.2786 mL
10 mM 0.2139 mL 1.0697 mL 2.1393 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.35 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.35 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Vebicorvir
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HY-109195
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