hDHODH-IN-12
hDHODH-IN-12 is a potent DHODH inhibitor with an IC50 value of 0.421 μM. DHODH is the rate-limiting enzyme in the de novo synthesis of pyrimidine which is essential in DNA/RNA Synthesis. hDHODH-IN-12 is present in the inner membrane of human mitochondria.hDHODH-IN-12 can be used for the research of lung cancer.
For research use only. We do not sell to patients.
- Formula: C22H15F3N4O3
- Molecular Weight:440.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
IC50: 0.421 μM (DHODH)[1]
hDHODH-IN-12 (compound 5c) (100 μM; 24 h) reduces cell viability in A549, H1299 and H1975 cell lines[1].
The TC50 of A549, H1299, and H1975 cells are 11, 11 and 15 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, H1299, and H1975 cells
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Concentration:100 μM
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Incubation Time:24 h
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Result:Reduced cell viability by more than 50%.
Chemical Information
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Molecular Weight 440.37
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Formula C22H15F3N4O3
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SMILES
O=C(C1=CNC2=C1C=C(NC3=CC=C([N+]([O-])=O)C=C3)C=C2)NC4=CC=CC(C(F)(F)F)=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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