2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis HCV SARS-CoV
  4. Setrobuvir

Setrobuvir (ANA598) is an orally active non-nucleosidic HCV NS5B polymerase inhibitor. ANA-598 inhibits both de novo RNA synthesis and primer extension, with IC50s between 4 and 5 nM. Setrobuvir also shows excellent binding affinity to SARS-CoV-2 RdRp and induces RdRp inhibition.

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Setrobuvir

Setrobuvir Chemical Structure

CAS No. : 1071517-39-9

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Based on 1 publication(s) in Google Scholar

Setrobuvir Related Antibodies

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Description

Setrobuvir (ANA598) is an orally active non-nucleosidic HCV NS5B polymerase inhibitor. ANA-598 inhibits both de novo RNA synthesis and primer extension, with IC50s between 4 and 5 nM. Setrobuvir also shows excellent binding affinity to SARS-CoV-2 RdRp and induces RdRp inhibition[1][2].

Cellular Effect
Cell Line Type Value Description References
Huh-7 CC50
100 μM
Compound: 38, ANA-598
Cytotoxicity against human HuH7 cells
Cytotoxicity against human HuH7 cells
[PMID: 22516671]
Huh-7 CC50
> 100 μM
Compound: 2c
Cytotoxicity against human HuH7 cells assessed as GAPDH release
Cytotoxicity against human HuH7 cells assessed as GAPDH release
[PMID: 19818610]
Huh-7 EC50
3 nM
Compound: 38, ANA-598
Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication by replicon assay
Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication by replicon assay
[PMID: 22516671]
Huh-7 EC50
52 nM
Compound: 38, ANA-598
Antiviral activity against Hepatitis C virus genotype 1a infected in human HuH7 cells assessed as inhibition of viral replication by replicon assay
Antiviral activity against Hepatitis C virus genotype 1a infected in human HuH7 cells assessed as inhibition of viral replication by replicon assay
[PMID: 22516671]
In Vitro

Setrobuvir (ANA598) is a non-nucleoside inhibitor that binds to the palm pocket of the HCV polymerase and has an EC50 against HCV genotype 1b/Con1-containing subgenomic replicons in the nanomolar range. Setrobuvir appears to inhibit both de novoinitiated RNA synthesis and primer extension, and its activity is unchanged by the presence of mutations that modify the activity of thumb-binding non-nucleoside inhibitors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Setrobuvir Related Antibodies
Clinical Trial
Molecular Weight

560.62

Formula

C25H25FN4O6S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CS(=O)(NC1=CC=C(C2=C1)N=C(C3=C(O)[C@]4([H])[C@@](C5)([H])CC[C@@]5([H])[C@]4([H])N(CC6=CC=C(F)C=C6)C3=O)NS2(=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 252.5 mg/mL (450.39 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7837 mL 8.9187 mL 17.8374 mL
5 mM 0.3567 mL 1.7837 mL 3.5675 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7837 mL 8.9187 mL 17.8374 mL 44.5935 mL
5 mM 0.3567 mL 1.7837 mL 3.5675 mL 8.9187 mL
10 mM 0.1784 mL 0.8919 mL 1.7837 mL 4.4593 mL
15 mM 0.1189 mL 0.5946 mL 1.1892 mL 2.9729 mL
20 mM 0.0892 mL 0.4459 mL 0.8919 mL 2.2297 mL
25 mM 0.0713 mL 0.3567 mL 0.7135 mL 1.7837 mL
30 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4864 mL
40 mM 0.0446 mL 0.2230 mL 0.4459 mL 1.1148 mL
50 mM 0.0357 mL 0.1784 mL 0.3567 mL 0.8919 mL
60 mM 0.0297 mL 0.1486 mL 0.2973 mL 0.7432 mL
80 mM 0.0223 mL 0.1115 mL 0.2230 mL 0.5574 mL
100 mM 0.0178 mL 0.0892 mL 0.1784 mL 0.4459 mL
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Setrobuvir Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Setrobuvir1071517-39-9ANA598ANA 598ANA-598DNA/RNA SynthesisHCVSARS-CoVHepatitis C virusSARS coronaviruspolymeraseRNAsynthesisprimerextensionmutationInhibitorinhibitorinhibit

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