1. Cell Cycle/DNA Damage
    Anti-infection
  2. DNA/RNA Synthesis
    HCV
    SARS-CoV
  3. Setrobuvir

Setrobuvir (Synonyms: ANA598)

Cat. No.: HY-13247
Handling Instructions

Setrobuvir (ANA598) is an orally active non-nucleosidic HCV NS5B polymerase inhibitor. ANA-598 inhibits both de novo RNA synthesis and primer extension, with IC50s between 4 and 5 nM. Setrobuvir also shows excellent binding affinity to SARS-CoV-2 RdRp and induces RdRp inhibition.

For research use only. We do not sell to patients.

Setrobuvir Chemical Structure

Setrobuvir Chemical Structure

CAS No. : 1071517-39-9

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Description

Setrobuvir (ANA598) is an orally active non-nucleosidic HCV NS5B polymerase inhibitor. ANA-598 inhibits both de novo RNA synthesis and primer extension, with IC50s between 4 and 5 nM. Setrobuvir also shows excellent binding affinity to SARS-CoV-2 RdRp and induces RdRp inhibition[1][2].

In Vitro

Setrobuvir (ANA598) is a non-nucleoside inhibitor that binds to the palm pocket of the HCV polymerase and has an EC50 against HCV genotype 1b/Con1-containing subgenomic replicons in the nanomolar range. Setrobuvir appears to inhibit both de novoinitiated RNA synthesis and primer extension, and its activity is unchanged by the presence of mutations that modify the activity of thumb-binding non-nucleoside inhibitors[1].

Molecular Weight

560.62

Formula

C₂₅H₂₅FN₄O₆S₂

CAS No.

1071517-39-9

SMILES

CS(=O)(NC1=CC=C(C2=C1)N=C(C3=C(O)[[email protected]]4([H])[[email protected]@](C5)([H])CC[[email protected]@]5([H])[[email protected]]4([H])N(CC6=CC=C(F)C=C6)C3=O)NS2(=O)=O)=O

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Keywords:

SetrobuvirANA598ANA 598ANA-598DNA/RNA SynthesisHCVSARS-CoVHepatitis C virusSARS coronaviruspolymeraseRNAsynthesisprimerextensionmutationInhibitorinhibitorinhibit

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Setrobuvir
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